2010 "Synaptic Transmission" Gordon Research Conference

描述（由申请人提供）： 该提案要求部分支持将于2010年7月25日至30日在缅因州比德福德美国大西洋沿岸的新英格兰大学校园举行的戈登研究会议系列的一部分，关于突触传递的国际会议。会议的广泛和长期目标是增加我们对突触传递的基本分子和细胞机制的理解。突触是神经系统的基本信号单位。突触传递是大脑功能各个方面的基础，与大多数神经系统疾病以及精神疾病和药物成瘾有关。本次会议的具体目标将是召集34位代表突触传递研究关键领域的发言人，共有140名与会者在一个相对孤立的环境中参加为期五天的会议。该计划将有两个主题讲座和八个会议，广泛解决当前的问题，在发射器释放，突触后信号和受体贩运，短期和长期的可塑性，跨突触信号，突触整合和电路，局部蛋白质合成和突触功能，以及一个会议致力于大脑疾病的突触基础。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。这一应用的重要性在于，戈登突触传递研究会议是推动国际“突触学家”研究的年度系列会议的重要组成部分。本申请的健康相关性在于，讨论将定义需要实验解决广泛的破坏性脑疾病的问题，包括神经退行性疾病、精神分裂症、自闭症谱系障碍、药物成瘾、情绪障碍和许多其他疾病，这些疾病可以被统称为突触病变。 公共卫生相关性：我们如何思考、感觉、行动和学习，都依赖于一个被称为突触传递的过程，即神经细胞之间的信息传递。本申请的健康相关性在于，对突触传递中的当前研究的讨论将定义在影响广泛的破坏性脑疾病的领域中需要实验解决的问题，所述破坏性脑疾病包括神经退行性疾病如帕金森病和阿尔茨海默病、精神分裂症、情绪障碍、自闭症谱系障碍、精神发育迟滞和药物成瘾。这些讨论将集中研究人员确定正常和疾病状态下的突触传递机制，并根据这些机制开发治疗方法。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Synaptic Transmission as part of the Gordon Research Conference series to be held at the University of New England Campus on the US Atlantic coast in Biddeford, Maine during the week of July 25-30, 2010. The broad and long term goal of the conference is to increase our understanding of the fundamental molecular and cellular mechanisms of synaptic transmission. The synapse serves as the basic signaling unit of the nervous system. Synaptic transmission underlies every aspect of brain function and is relevant to most neurological diseases, as well as mental illness and drug addiction. The specific aims of this meeting will be to convene 34 speakers that represent critical areas of synaptic transmission research with a total of 140 participants for a five day conference in a relatively isolated setting. The program will have two keynote lectures and eight sessions that broadly address current issues in transmitter release, postsynaptic signaling and receptor trafficking, short- and long-term plasticity, trans-synaptic signaling, synaptic integration and circuits, local protein synthesis and synaptic function, and a session devoted to the synaptic basis of brain disorders. In addition, two evening poster sessions will permit all participants to contribute to these topics. The significance of this application is that the Gordon Research Conference on Synaptic Transmission is a critical component of the yearly series of conferences that propel research in the international community of "synaptologists". The health relatedness of this application is that the discussions will define the questions that require experimental resolution of a wide range of devastating brain disorders, including neurodegenerative diseases, schizophrenia, autism spectrum disorders, drug addiction, mood disorders and many others, which can collectively be regarded as synaptopathies. PUBLIC HEALTH RELEVANCE: How we think, feel, act and learn, all rely on a process known as synaptic transmission, namely, the information transfer between nerve cells. The health relatedness of this application is that the discussions of current research in synaptic transmission will define the questions that require experimental resolution in areas that affect a wide range of devastating brain disorders, including neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, schizophrenia, mood disorders, autism spectrum disorders, mental retardation and drug addiction. These discussions will focus researchers identifying the mechanisms of synaptic transmission under normal and disease states, and developing therapies based on these mechanisms.