2010 Photosensory Receptors and Signal Transduction GRC/GRS

描述(申请人提供)：光感官感受器和信号转导GRC会议是在光接收的机制基础和影响领域的卓越会议。该会议成立于2000年，每两年轮流在美国和欧洲举行一次会议，下一次会议定于2010年4月18日至23日在Il Ciocco地点举行，此前曾举行过三次会议。光传感器社区涵盖了各种各样的领域。为此，本次会议的主要目标是为研究光探测的生物、化学和物理方面的研究人员提供相互之间而不是在更有限的子社区内共享他们的最新数据。在基因组测序工作提供的新可用的光传感器的爆炸性增长的帮助下，这一领域加入了新的光感受器家族和许多现有光感受器的新成员。综上所述，这些系统提供了一组不同的系统来回答蛋白质信号传递中的基本问题：小分子生色团如何引发周围蛋白质的变构变化？这些更改是如何传递到下游效应器的？如何调整这一过程的参数以适应生物系统的需要？这些问题是人类生理学(如视觉、昼夜节律)以及细菌、植物和动物生物学的核心问题。此外，这些对于开发新的生物学研究工具和对蛋白质结构/功能/调节的一般理解是重要的。 GRC会议由口头陈述和海报展示两部分组成。口头报告以传统的GRC形式组织，在五天内有九次会议，以促进不同光感受器家族的比较讨论。将由生物化学、生物物理学、细胞生物学、化学、微生物学、生理学和植物生物学领域的知名研究人员发表演讲，与新人和职业生涯早期的科学家混合，取得非凡的新成果。会议将由著名的互动式研究人员主持，他们利用自己的专门知识，结合发言者和实地主要问题的背景，综合各种成果。作为口头陈述的补充，海报会议将为所有与会者提供机会，介绍他们的调查结果并与该领域的其他成员讨论。在2010年的会议上，我们将增加一个由学生和博士后组织和参加的戈登研究研讨会，为我们社区的这一关键群体提供更多的演讲和网络机会。 公共卫生相关性：光感官受体和信号转导GRC会议为光接收领域的研究人员提供了一个论坛，以会面和讨论受体机制方面共同感兴趣的问题。这个领域是极其多样化的，因为光探测的相同原理在生物学中被广泛保守，因此需要召开一次会议来整合这个社区。这里讨论的问题是人类生理学(例如，视觉、昼夜节律)、生物学研究的新工具的开发以及对蛋白质结构/功能/调节的一般理解的中心问题。

DESCRIPTION (provided by applicant): The Photo sensory Receptors and Signal Transduction GRC meeting is the pre-eminent meeting in the field of the mechanistic basis and effects of photoreception. Having been established in 2000, the meeting alternates between US and European sites every two years, with the next meeting scheduled for April 18-23, 2010 at the Il Ciocco site used for three prior conferences. The photo sensor community encompasses a diverse variety of fields. For this reason, the primary objective of this meeting is to provide researchers studying the biological, chemical and physical aspects of light detection to share their newest data with each other rather than within more limited subcommunities. Aided by the explosion of newly-available photosensors provided by genomic sequencing efforts, this field has been joined by both new families of photoreceptors and a many new members of existing ones. Taken together, these provide a diverse group of systems to answer fundamental questions in protein signaling: How can small molecule chromophores trigger allosteric changes to surrounding proteins? How are these changes transmitted to downstream effectors? How are parameters of this process tuned to match the needs of the biological system? These questions are of central interest to human physiology (e.g. vision, circadian rhythms) and bacterial, plant and animal biology in general. Further, these are important to the development of novel biological research tools and general understanding of protein structure/function/regulation. The GRC meeting consists of both oral presentations and poster sessions. Oral presentations are organized in a conventional GRC format, with nine sessions over five days that facilitate comparative discussions of different families of photoreceptors. Presentations will be given by established investigators in the fields of biochemistry, biophysics, cell biology, chemistry, microbiology, physiology and plant biology, mixed with newcomers and early career scientists with exceptional new results. Sessions will be chaired by prominent and interactive researchers who bring their expertise to integrate results across speakers and in context of the major questions in the field. Complementing the oral presentations, poster sessions will provide opportunities for all attendees to present and discuss their findings with other members of the field. New to the 2010 meeting, we will add a Gordon Research Seminar organized and attended by, students and postdocs to give additional presentation and networking opportunities to this critical group of our community. PUBLIC HEALTH RELEVANCE: The Photo sensory Receptors and Signal Transduction GRC meeting provides a forum for researchers in the area of photoreception to meet and discuss issues of common interest in receptor mechanism. This field is extremely diverse, as the same principles of light detection are conserved widely across biology, and hence the need for a meeting which integrates this community. The issues discussed here are of central interest to human physiology (e.g. vision, circadian rhythms), the development of novel tools for biological research and general understanding of protein structure/function/regulation.