Temporal Processing Properties of the Auditory System in Cochlear Implant Systems

描述（由申请人提供）：人工耳蜗植入体用户听觉系统的时间处理特性项目描述人工耳蜗植入体（CI）的主要挑战之一是CI患者的言语感知性能存在很大的变异性。最近的研究表明，这种语言表现的变异性和CI患者的心理测量的时间处理之间的显着相关性。除了这些行为测量之外，对重复刺激的神经反应的时间特性提供了关于听觉系统对声音中的时间线索的处理的重要信息。目前尚不清楚客观测量的神经反应与时间处理和言语感知的行为测量如何相关。本研究旨在探讨脑梗死患者四种听觉诱发电位（AEP）的时间特性：1）电复合动作电位（ECAP），2）电听觉脑干反应（EABR），3）电迟发听觉诱发电位（ELAEP），4）声学LAEP。我们将比较CI用户的时间处理和言语感知能力的神经生理和行为措施。我们假设LAEP的时间特性与行为测量的相关性优于ECAP和EABR。从理论上讲，从拟议的研究结果将提供重要的见解CI患者的言语理解的大变异。实际上，拟议的研究将有助于确定适当的电生理措施，可用于客观地评估CI的好处。这项研究可能会导致未来的努力，以改善CI用户的声音的时间表示。 公共卫生相关性：本研究旨在探讨人工耳蜗使用者的听觉系统如何使用电生理学和行为学方法处理声音信息。它将提供重要的见解，为什么一些患者比其他患者从植入中获得更大的益处。它还将导致识别最有前途的电生理工具，可用于客观测量植入结果或康复策略的功效。

DESCRIPTION (provided by applicant): Temporal processing properties of the auditory system in cochlear implant users Description of the Project One of the major challenges in cochlear implants (CIs) is the large variability in CI patients' speech perception performance. Recent studies have shown significant correlations between this variability in speech performance and CI patients' psychophysically measured temporal processing. Besides these behavioral measures, the temporal properties of neural responses to repeated stimuli provide important information about the auditory system's processing of temporal cues in sounds. It is unclear how objectively measured neural responses are related to behavioral measures of temporal processing and speech perception. The goal of this project is to investigate the temporal properties of four types of auditory evoked potentials (AEPs) in CI patients: 1) the electric compound action potential (ECAP), 2) the electric auditory brainstem response (EABR), 3) the electric late auditory evoked potential (ELAEP), and 4) the acoustic LAEP. We will compare neurophysiological and behavioral measures of temporal processing and speech perception abilities in CI users. We hypothesize that the temporal properties of the LAEP are better correlated to behavioral measures than those of the ECAP and the EABR. Theoretically, the results from the proposed study will provide important insights into the large variability in CI patients' speech understanding. Practically, the proposed research will help to identify appropriate electrophysiological measures that can be used to objectively assess CI benefits. This research may lead to future efforts toward improving the temporal representation of sounds in CI users. PUBLIC HEALTH RELEVANCE: This project examines how the auditory system of cochlear implant users processes information of sounds over time using electrophysiological and behavioral methods. It will provide important insights into why some patients receive greater benefits than others from implantation. It will also lead to the identification of the most promising electrophysiological tools that can be used to objectively measure outcomes of implantation or the efficacy of rehabilitation strategies.