2010 Pineal Cell Biology Gordon Research Conference

2010年松果体细胞生物学戈登研究会议

• 批准号: 7902655
• 负责人: DAVID Raymond WEAVER
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-06 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902655
• 关键词: Area; Biology; Breeding; Cell physiology; Cellular biology; Circadian Rhythms; Collaborations; Communication; Country; Data; Development; Developmental Biology; Discipline; Disease; Educational Status; Endocrine; Feedback; Fertilization; Future; Genetic; Goals; Government; Health; Hormones; Human; Laboratories; Link; Mammals; Medicine; Melatonin; Metabolic Diseases; Metabolism; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Output; Participant; Physiological; Physiology; Pineal gland; Regulation; Reproduction; Research; Research Personnel; Retinal; Scientist; Sleep; Sleep Wake Cycle; Texas; Therapeutic; Time; Translational Research; dietary supplements; human subject; insight; lectures; meetings; oncology; posters; programs; public health relevance; response; sleep regulation; symposium; tumor growth

DESCRIPTION (provided by applicant): Partial support is requested for the 11th Gordon Research Conference on Pineal Cell Biology to be held February 7-12 at Hotel Galvez in Galveston, Texas. The major objectives and long-term goals of the 2010 Gordon Research Conference on Pineal Cell Biology are to increase our understanding of the molecular and cellular function of the pineal gland, of how the rhythmic synthesis and release of the pineal hormone melatonin contributes to vertebrate physiology, and the importance of circadian rhythms in physiological functions and disease. Melatonin has a wide range of functions, ranging from effects on the sleep/wake cycle in humans to the control of photoperiodic responses in seasonally breeding mammals, and it is widely used as an over-the-counter dietary supplement. Thus, it is important that the physiology of the pineal gland and its principal output hormone, melatonin, be understood. The study of the pineal cell biology is inextricably linked to the study of circadian rhythms. An objective of this meeting is thus to explore aspects of circadian rhythms that are at the interface with melatonin and melatonin action, including regulation of sleep and circadian rhythms, metabolism, reproduction, retinal function and tumor growth. The specific aims of the Gordon Conference on Pineal Cell Biology are: 1) To provide a forum for communication of recent advances in the areas of Pineal Cell Biology, melatonin action, and circadian rhythms, leading to identification of key opportunities for future study, 2) To stimulate interaction among researchers studying different species and using a wide range of experimental and technical approaches, so as to promote understanding of the potential for interdisciplinary and collaborative research, 3) To promote collaboration by bringing together scientists from many different research groups and countries, and at different levels of training, and 4) To promote translational research by bringing together investigators studying human subjects in pineal and circadian research with those investigating other species. The Conference will achieve these aims by providing a forum for presentation of the latest advances. The Conference will bring together a diverse group of approximately 130 scientists from leading academic, industrial and government laboratories around the world to discuss current research directions and themes, and is expected to provide stimulating and intense discussion leading to insights and general principles emerging in pineal cell biology and related topics. The Gordon Conference format consists of lecture sessions in the morning and evening, with ample time for discussion. Poster sessions will allow additional participants to present data and receive feedback. The confirmed Invited Participants (listed in the Tentative Program) include experts using a broad variety of approaches, and from diverse disciplines, include neuroscience, (retinal biology, neurodegenerative diseases, and sleep medicine), developmental biology, genetics, metabolism, and oncology. Through convening such an interdisciplinary group of experts, the Conference will identify key areas for future research into the impact of melatonin and circadian rhythms on human health and disease. PUBLIC HEALTH RELEVANCE: The pineal hormone, melatonin, influences circadian organization, sleep/wake cycles, retinal function, metabolism and tumor growth. The Conference objective is to bring together leading scientists to discuss new developments in the field, to increase the level of interaction and cross-fertilization between disciplines and thus promote collaboration and translational research. The meeting will have health relevance through promoting an understanding of the contribution of melatonin and circadian rhythms, (and the therapeutic potential of manipulating them) in areas including sleep/wake regulation, and neurodegenerative, endocrine and metabolic disorders.

描述（由申请人提供）：部分支持要求为第11届戈登研究会议的松果体细胞生物学将于2月7日至12日在酒店加尔维斯顿加尔维斯顿，得克萨斯州。2010年戈登松果体细胞生物学研究会议的主要目标和长期目标是增加我们对松果体的分子和细胞功能的理解，松果体激素褪黑激素的节律性合成和释放如何有助于脊椎动物生理学，以及生理功能和疾病中昼夜节律的重要性。褪黑激素具有广泛的功能，从对人类睡眠/觉醒周期的影响到控制季节性繁殖哺乳动物的光周期反应，并且它被广泛用作非处方膳食补充剂。因此，重要的是，松果体的生理和它的主要输出激素，褪黑激素，被理解。松果体细胞生物学的研究与昼夜节律的研究密不可分。因此，本次会议的目的是探讨与褪黑激素和褪黑激素作用有关的昼夜节律方面，包括睡眠和昼夜节律的调节、代谢、生殖、视网膜功能和肿瘤生长。戈登松果体细胞生物学会议的具体目标是：1）提供一个论坛，交流松果体细胞生物学、褪黑激素作用和昼夜节律领域的最新进展，从而确定未来研究的关键机会，2）刺激研究不同物种的研究人员之间的互动，并使用广泛的实验和技术方法，以促进对跨学科和合作研究潜力的理解，3）通过汇集来自许多不同研究团体和国家的不同培训水平的科学家来促进合作，和4）通过将研究人类松果体和昼夜节律研究的研究人员与研究其他物种会议将通过提供一个介绍最新进展的论坛来实现这些目标。会议将汇集来自世界各地领先的学术，工业和政府实验室的约130名科学家的多元化小组，讨论当前的研究方向和主题，并预计将提供刺激和激烈的讨论，导致松果体细胞生物学和相关主题中出现的见解和一般原则。戈登会议的形式包括上午和晚上的讲座，有充足的时间进行讨论。海报会议将使更多的参与者能够展示数据和获得反馈。确认的受邀参与者（在暂定计划中列出）包括使用各种方法的专家，来自不同学科，包括神经科学（视网膜生物学，神经退行性疾病和睡眠医学），发育生物学，遗传学，代谢和肿瘤学。通过召集这样一个跨学科专家组，会议将确定未来研究褪黑激素和昼夜节律对人类健康和疾病影响的关键领域。 公共卫生相关性：松果体激素，褪黑激素，影响昼夜节律的组织，睡眠/觉醒周期，视网膜功能，新陈代谢和肿瘤生长。会议的目标是汇集领先的科学家讨论该领域的新发展，提高学科之间的互动和交叉施肥水平，从而促进合作和转化研究。会议将通过促进对褪黑激素和昼夜节律的贡献的理解，（以及操纵它们的治疗潜力）在睡眠/觉醒调节，神经退行性疾病，内分泌和代谢紊乱等领域具有健康相关性。