2010 Myelin Gordon Research Conference

描述（由申请人提供）：在这份申请中，我们要求支持将于2010年2月15日至19日在加州文图拉举行的2010年戈登髓磷脂会议。我们对神经系统中髓鞘细胞生物学的了解继续迅速扩大。自2008年5月在Il Ciocco举行的最后一次会议以来，对髓鞘细胞发育的基本生物学研究和对成人中枢神经系统髓鞘修复潜力的理解在几个领域取得了进展。成人中枢神经系统中含有能够产生新髓鞘的干细胞和神经前体，这一认识将髓鞘细胞的发生和分化研究推向了生物医学研究的前沿。此外，现在的重要数据表明，潜在的髓磷脂病理可能影响其他中枢神经系统疾病以及多发性硬化症。第十届戈登髓磷脂会议“髓磷脂的发育和疾病”的计划旨在利用这些进展并进一步加速该领域的研究。我们已设法减少与前几次会议的发言者的重叠，并扩大将涉及的领域。髓磷脂生物学研究领域的健康发展取决于一个充满活力的研究团队，而这主要是由提拔年轻的、新独立的科学家来推动的。我们正在共同努力邀请初级教员级别的研究人员在本次会议上发言。正在鼓励较资深的研究人员担任会议主席并提供该领域的概述。这将使年轻的研究人员有一个独特的机会来展示他们的工作，并为他们的科学同行所知。很少有其他地方能提供这样的机会。将适当注意确保发言者名册中的性别平衡。作为我们在髓磷脂生物学领域培养受训人员并特别鼓励他们参与的承诺的一部分，我们将在资金允许的情况下提供旅费和注册津贴。所有与会者将被要求作出口头报告或出示海报。我们认为，海报会议是促进具有不同专业知识的科学家之间富有成效的互动的关键因素。与戈登会议的目标保持一致，这种相互作用将为髓磷脂生物学领域提供动力和方向。本次会议重点介绍了髓磷脂在中枢和周围神经系统中的研究进展。这些进展对于我们理解神经系统发育和功能的基本机制以及它与许多人类疾病（如中枢神经系统多发性硬化症）的相关性都是重要的。2010年的会议还将讨论将潜在髓磷脂病理学与其他人类神经和精神疾病联系起来的新数据。我们对神经系统中髓鞘细胞生物学的理解继续迅速扩大，特别关注成人中枢神经系统中含有能够产生新髓鞘的神经干/前体细胞群体这一事实。这突出了我们研究髓鞘形成和再髓鞘形成的潜在临床意义。

DESCRIPTION (provided by applicant): In this application we are requesting support for the 2010 Gordon Conference on Myelin to be held in Ventura, California, February 15-19, 2010. Our understanding of the biology of myelinating cells in the nervous system continues to expand rapidly. Since the last meeting in Il Ciocco in May 2008, investigation into the basic biology of myelinating cells in development and understanding of the potential for myelin repair in the adult CNS has moved forward in several areas. The realization that the adult CNS contains populations of stem cells and neural precursors capable of generating new myelin has propelled studies on the genesis and differentiation of myelinating cells to the forefront of biomedical research. Furthermore, important data now indicate the possibility that underlying myelin pathology may impact other CNS diseases as well as multiple sclerosis. The program for the tenth Gordon Conference on Myelin "Development and Diseases of Myelin" is designed to capitalize on these advances and further accelerate research in this area. We have attempted to reduce overlap with speakers of previous meetings and expand the areas that will be covered. The health of the field of myelin biology research depends on a dynamic group of investigators and this is driven largely by promoting young, newly independent scientists. We are making a concerted effort to invite investigators at the junior faculty level to be speakers at this meeting. The more senior investigators are being encouraged to act as session chairs and provide overviews of the field. This will allow the young investigators a unique opportunity to present their work, and become known to their scientific peers. Few other venues offer such an opportunity. Appropriate attention will be paid to ensure gender balance in the roster of speakers. As part of our commitment to fostering trainees in the field of myelin biology and to specifically encourage their participation, we will offer stipends for travel and registration as funds permit. All attendees will be expected to contribute to an oral presentation or present a poster. We believe that poster sessions are a key element in fostering productive interactions between scientists with different expertise. In keeping with the goals of the Gordon Conference, such interactions will provide impetus and direction to the field of myelin biology. This meeting highlights the advances made in research on myelin in the central and peripheral nervous system. These advances are important both for our understanding of basic mechanisms of nervous system development and function and for its relevance to numerous de/dysmyelinating human diseases, such as multiple sclerosis in the central nervous system. The 2010 meeting will also discuss new data linking underlying myelin pathology with other human neurologic and psychiatric diseases. Our understanding of the biology of myelinating cells in the nervous system continues to expand rapidly, with a particular focus on the fact that the adult CNS contains populations of neural stem/precursor cells capable of generating new myelin. This highlights the potential clinical implications for our investigations on myelination and remyelination. PUBLIC HEALTH RELEVANCE: This meeting highlights the advances made in research on myelin in the central and peripheral nervous system. These advances are important both for our understanding of basic mechanisms of nervous system development and function and for its relevance to numerous de/dysmyelinating human diseases, such as multiple sclerosis in the central nervous system. The 2010 meeting will also discuss new data linking underlying myelin pathology with other human neurologic and psychiatric diseases. Our understanding of the biology of myelinating cells in the nervous system continues to expand rapidly, with a particular focus on the fact that the adult CNS contains populations of neural stem/precursor cells capable of generating new myelin. This highlights the potential clinical implications for our investigations on myelination and remyelination.