APPLICATION OF PSYCHOPHYSICAL MODELS TO VISUAL DISORDERS

描述（由申请人提供）：本研究项目的长期功能是将视力缺陷与疾病过程的潜在细胞病理生理学联系起来，目前的重点是青光眼。本研究应用定量皮质神经池模型分析青光眼的周视损伤，旨在减少周视变异性，改善青光眼损伤临床指标之间的关系。具体目的：1)利用定量神经模型优化对比敏感度验光（CSP）在青光眼患者的临床应用。我们的神经模型将用于优化CSP参数和算法的四个因素：筛选（识别缺陷），测试-重测试（识别进展），表征（识别损伤模式），以及与结构措施的关系。2)利用定量神经模型分析英国青光眼治疗研究（UKGTS）数据中常规自动视距测量（CAP）与成像措施之间的关系。将分析一个大型前瞻性纵向数据集，根据模型预测与四种不同成像测试结果相关的周距灵敏度。具体目的3)利用定量神经模型对青光眼损伤的周边测量和结构测量进行评估，以评估其内部和之间的长期波动与进展。将进行一项前瞻性纵向研究，以测试该模型关于CSP与标准临床测量之间关系的预测，包括周长和成像。

DESCRIPTION (provided by applicant): The long-term function of this research program is to relate visual deficits to the underlying cellular pathophysiology of disease processes, with the current focus exclusively on glaucoma. The proposed research applies a quantitative cortical neural pooling model to analysis of perimetric damage produced by glaucoma, with the goals of reducing perimetric variability and improving relations between clinical measures of glaucomatous damage. There are three Specific Aims: Specific Aim 1) To optimize contrast sensitivity perimetry (CSP) for clinical use in patients with glaucoma, using a quantitative neural model for perimetry. Our neural model will be used to optimize CSP parameters and algorithms in terms of four factors: screening (identify defects), test-retest (identify progression), characterization (identify pattern of damage), and relations with structural measures. Specific Aim 2) To analyze relations between conventional automated perimetry (CAP) and imaging measures in data from the United Kingdom Glaucoma Treatment Study (UKGTS), using a quantitative neural model. A large prospective longitudinal dataset will be analyzed in terms of model predictions relating perimetric sensitivity with results from four different imaging tests. Specific Aim 3) To assess long-term fluctuation versus progression within and between perimetric and structural measures of glaucomatous damage, using a quantitative neural model for perimetry. A prospective longitudinal study will be conducted to test predictions of the model concerning relations between CSP and standard clinical measures, both perimetric and imaging. PUBLIC HEALTH RELEVANCE: Perimetry measures visual function across the visual field, and is used routinely for diagnosing and following patients with glaucoma, one of the leading causes of blindness in the US and globally. The proposed research will produce a deeper scientific understanding of perimetry, and will lead to improved methods for using perimetry in clinical studies, treatment trials and care of individual patients. The potential public health benefit is substantial, given the large number of patients with glaucoma.