3D RNFL Structure And High-Resolution Perimetry For Assessing Glaucomatous Damage

用于评估青光眼损伤的 3D RNFL 结构和高分辨率视野测量

• 批准号: 10368026
• 负责人: WILLIAM H. SWANSON
• 金额: $ 45.2万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10368026
• 关键词: 3-Dimensional; Address; Affect; Algorithms; Axon; Back; Basic Science; Biological; Biology; Blindness; Cell Count; Cells; Cessation of life; Clinical; Clinical Research; Clinical Trials; Custom; Defect; Detection; Development; Devices; Diagnosis; Disease; Disease Progression; Distant; Eye; Eye diseases; Functional disorder; Glaucoma; Goals; Grant; Image; Individual; Location; Longitudinal Studies; Measurement; Measures; Methods; Morphologic artifacts; Optic Disk; Optical Coherence Tomography; Optics; Pathogenesis; Patient Care; Patients; Perimetry; Persons; Population; Procedures; Process; Property; Psychophysics; Reference Values; Research; Research Personnel; Research Project Grants; Resistance; Resolution; Retina; Retinal Ganglion Cells; Role; Sampling; Scanning; Scotoma; Staging; Statistical Data Interpretation; Stimulus; Structure; System; Systems Analysis; Testing; Time; Training; Treatment Effectiveness; Update; Variant; Vision; Visual Fields; Visual impairment; adaptive optics; adaptive optics scanning laser ophthalmoscopy; clinical imaging; density; effectiveness evaluation; ganglion cell; imaging modality; improved; innovation; neural model; optical imaging; patient variability; retinal damage; retinal imaging; retinal nerve fiber layer; synergism; tool

7. Project Summary Abstract Glaucoma is one of the leading causes of preventable blindness, and currently available treatments are not sufficient to halt progression in many patients. While much has been learned about the biology of glaucoma, development of new forms of treatment has been stymied by three barriers: high between-subject variability in ganglion cell number in normal eyes, high within-subject variability for perimetry in patients with glaucoma, and the slow rate of progression of the disease. The proposed research integrates neural modeling and clinical research to develop improved methods for diagnosing glaucoma and for assessing progression towards blindness. The results are intended to improve measures for both clinical trials and ongoing patient care, while at the same time improving basic science understanding of the pathophysiology of glaucoma and providing guidance for biological studies of the disease process. Innovative uses of clinical devices will guide testing with custom systems, and statistical analyses will utilize the synergy between structural and functional measures of glaucomatous damage. High-resolution retinal imaging of retinal nerve fiber layer (RNFL) will be performed on patients with glaucoma using a custom advanced adaptive optics scanning laser ophthalmoscope (AOSLO) as well as custom use of spectral domain optical coherence tomography (SD-OCT). High-resolution perimetry will be performed in corresponding regions of the visual field, using custom stimuli that are resistant to optical artifacts that affect conventional perimetry. Specific Aim 1 will determine the role of ganglion cell dysfunction in between-subject differences in the amount of visual loss corresponding to clinically observed reflectance defects, and assess longitudinal changes. Specific Aim 2 will utilize the synergy between structural and functional measures to develop perimetric algorithms that interact dynamically with information about RNFL structure. Specific Aim 3 will develop methods that dramatically improve the ability to detect wedge defects that are poorly sampled by conventional perimetry.

7.项目摘要 青光眼是可预防失明的主要原因之一，目前可用的治疗方法不是 足以阻止许多患者的进展。虽然人们对青光眼的生物学已经了解了很多， 新的治疗形式的发展受到三个障碍的阻碍： 正常眼的神经节细胞数量，青光眼患者视野检查的受试者内变异性高，以及 这种疾病的缓慢发展速度。该研究将神经建模和临床 研究开发用于诊断青光眼和评估青光眼进展的改进方法 失明这些结果旨在改善临床试验和正在进行的患者护理的措施， 同时提高对青光眼病理生理学的基础科学认识， 疾病过程的生物学研究指南。临床设备的创新使用将指导测试， 定制系统和统计分析将利用结构和功能措施之间的协同作用， 昏迷性损伤。视网膜神经纤维层（RNFL）的高分辨率视网膜成像将在 青光眼患者使用定制的高级自适应光学扫描激光检眼镜（AOSLO）， 以及谱域光学相干断层扫描（SD-OCT）的定制使用。高分辨率视野检查将 在视野的相应区域中进行，使用对光学敏感的自定义刺激， 影响常规视野检查的伪影。具体目标1将确定神经节细胞功能障碍在 与临床观察到的反射率相对应的视力丧失量的受试者间差异 缺陷，并评估纵向变化。具体目标2将利用结构和 功能性措施，以开发周边算法，动态地与有关RNFL的信息进行交互 结构具体目标3将开发方法，大大提高检测楔缺陷的能力， 通过常规视野检查很难采样。