APPLICATION OF PSYCHOPHYSICAL MODELS TO VISUAL DISORDERS

心理物理模型在视觉障碍中的应用

• 批准号: 8374410
• 负责人: WILLIAM H. SWANSON
• 金额: $ 49.19万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8374410
• 关键词: Affect; Agreement; Algorithms; American; Anatomy; Area; Basic Science; Blindness; Caring; Clinical; Clinical Protocols; Clinical Research; Contrast Sensitivity; Data; Data Set; Databases; Defect; Detection; Development; Diagnosis; Disease; Electrophysiology (science); Frequencies; Functional disorder; Glaucoma; Goals; Grant; Health Benefit; Image; Individual; Lead; Location; Longitudinal Studies; Measurement; Measures; Methods; Modeling; Nose; Optic Disk; Optical Coherence Tomography; Patients; Pattern; Perimetry; Process; Psychophysics; Public Health; Quantitative Evaluations; Research; Research Project Grants; Scanning; Statistical Methods; Stimulus; Structure; Testing; United Kingdom; Vision; Vision Disorders; Visual; Visual Fields; clinically significant; design; improved; innovation; macula; neural model; next generation; optic nerve disorder; programs; prospective; public health relevance; relating to nervous system; retinal nerve fiber layer; screening; tomography; tool; treatment trial

DESCRIPTION (provided by applicant): The long-term function of this research program is to relate visual deficits to the underlying cellular pathophysiology of disease processes, with the current focus exclusively on glaucoma. The proposed research applies a quantitative cortical neural pooling model to analysis of perimetric damage produced by glaucoma, with the goals of reducing perimetric variability and improving relations between clinical measures of glaucomatous damage. There are three Specific Aims: Specific Aim 1) To optimize contrast sensitivity perimetry (CSP) for clinical use in patients with glaucoma, using a quantitative neural model for perimetry. Our neural model will be used to optimize CSP parameters and algorithms in terms of four factors: screening (identify defects), test-retest (identify progression), characterization (identify pattern of damage), and relations with structural measures. Specific Aim 2) To analyze relations between conventional automated perimetry (CAP) and imaging measures in data from the United Kingdom Glaucoma Treatment Study (UKGTS), using a quantitative neural model. A large prospective longitudinal dataset will be analyzed in terms of model predictions relating perimetric sensitivity with results from four different imaging tests. Specific Aim 3) To assess long-term fluctuation versus progression within and between perimetric and structural measures of glaucomatous damage, using a quantitative neural model for perimetry. A prospective longitudinal study will be conducted to test predictions of the model concerning relations between CSP and standard clinical measures, both perimetric and imaging.

描述（由申请人提供）：本研究项目的长期功能是将视觉缺陷与疾病过程的潜在细胞病理生理学联系起来，目前仅关注青光眼。拟议的研究应用定量皮质神经池模型来分析青光眼引起的周边损害，目的是减少周边变异性和改善青光眼损害的临床措施之间的关系。有三个具体目标：具体目的1）使用视野检查的定量神经模型，优化青光眼患者的对比敏感度视野检查（CSP）。我们的神经模型将用于优化CSP参数和算法的四个因素：筛选（识别缺陷），测试-重测（识别进展），表征（识别模式的损坏），和结构措施的关系。具体目的2）使用定量神经模型分析英国青光眼治疗研究（UKGTS）数据中常规自动视野检查（CAP）和成像测量之间的关系。一个大型的前瞻性纵向数据集将进行分析的模型预测相关的周边灵敏度与结果从四个不同的成像测试。具体目的3）使用视野定量神经模型评估昏迷性损害的视野和结构测量内和之间的长期波动与进展。将进行一项前瞻性纵向研究，以测试CSP与标准临床测量（包括视野测量和成像）之间关系的模型预测。

项目成果

Quantifying effects of retinal illuminance on frequency doubling perimetry.

量化视网膜照度对倍频视野检查的影响。

• DOI: 10.1167/iovs.04-0264
• 发表时间: 2005
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Swanson,WilliamH;Dul,MitchellW;Fischer,SusanE
• 通讯作者: Fischer,SusanE

S-cone spatial contrast sensitivity can be independent of pre-receptoral factors.

S 锥空间对比敏感度可以独立于感受器前因素。

• DOI: 10.1016/0042-6989(96)00047-8
• 发表时间: 1996
• 期刊: Vision research
• 影响因子: 1.8
• 作者: Swanson,WH

The importance of controlled illumination in color vision testing in a pediatric ophthalmology clinical practice.

儿科眼科临床实践中色觉测试中受控照明的重要性。

• DOI: 10.3928/0191-3913-19930101-10
• 发表时间: 1993
• 期刊: Journal of pediatric ophthalmology and strabismus
• 影响因子: 1.2
• 作者: Stager,DR;Everett,M;Swanson,WH
• 通讯作者: Swanson,WH

Evaluation of a two-stage neural model of glaucomatous defect: an approach to reduce test-retest variability.

青光眼缺陷两阶段神经模型的评估：减少重测变异性的方法。

• DOI: 10.1097/01.opx.0000225091.60457.f4
• 发表时间: 2006
• 期刊: Optometry and vision science : official publication of the American Academy of Optometry
• 作者: Pan,Fei;Swanson,WilliamH;Dul,MitchellW
• 通讯作者: Dul,MitchellW

Between-Subject Variability in Healthy Eyes as a Primary Source of Structural-Functional Discordance in Patients With Glaucoma.

• DOI: 10.1167/iovs.15-18633
• 发表时间: 2016-02
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Ashimatey BS;Swanson WH
• 通讯作者: Swanson WH