Radiation Biology of EPR Oxygen Images

电子顺磁共振（EPR）氧成像（EPROI）已被证明可以提供动物肿瘤的定量定位PO2图像，包括几种同基因小鼠，大鼠和兔子。窄EPR光谱线的氧展宽在每个1mm3图像体素中报告了1-3 torr分辨率的PO2。这项工作显示了i)氧图像和点氧测量技术（Oxylite）之间的第一个共定位相关性；加入EPROI体素小于0 torr （HFio）提供的信息后，50%肿瘤对照剂量的锐化具有统计学意义；3)吡莫硝唑图像与EPROI PO2的共配准；4)VEOF与基于EPROI的HEw具有显著的空间相关性。对于给定的周期，我们提出以下具体目标：1)确定来自EPROI的局部氧信息与吡咪唑保留和诱导缺氧蛋白之间的关系；2)在氧图像后将小鼠肿瘤治疗为TCDSO，并确定HFio和其他EPROT肿瘤统计数据的预测有效性。

Electron Paramagnetic Resonance (EPR Oxygen Images (EPROI) have been shown to provide quantitative localized PO2 images of animal tumors including several in syngeneic mice, and in rats, and rabbits. The oxygen broadening of narrow EPR spectral lines report the PO2 with 1-3 torr resolution in each 1mm3 image voxeL This work has shown i) the first co-localized correlation between an oxygen image and a point oxygen measurement technique (Oxylite) 2) independent, statistically significant sharpening of the 50% tumor control dose with the addition of the information provided by the fraction of EPROI voxels less than io torr (HFio) 3) co-registration of pimonidazole images nth EPROI PO2 and 4) significant spatial correlation of VEOF and EPROI based HEw. We propose the following specific aims for the given cycle: i) Determining the relation between the localized oxygen information from the EPROI and pimonidazole retention and induction of hypoxia proteins, 2) Treatment of murine tumors to TCDSO after oxygen images and determining the predictive effectiveness of the HFio and other EPROT tumor statistics.