A GLYCOSYLATED FORM OF THE HUMAN CARDIAC HORMONE PRO B-TYPE NATRIURETIC PEPTIDE

人类心脏激素 PRO B 型钠尿肽的糖基化形式

• 批准号: 8168748
• 负责人: Daniel B. Crimmins
• 金额: $ 1.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168748
• 关键词: Antibodies; Binding; Biological Assay; Brain natriuretic peptide; Cardiac; Clinical; Clinical Markers; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Consensus; Data; Epitopes; Funding; Gold; Grant; Heart Hypertrophy; Heart failure; Heel; Hormones; Human; Immunoassay; Institution; Investigation; Left ventricular structure; Masks; Measures; Molecular; Myocardial dysfunction; N-terminal; Natriuretic Peptides; Nature; Peptides; Reporting; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) and proBNP are used as gold standard clinical markers of myocardial dysfunction such as cardiac hypertrophy and left ventricle heart failure. The actual circulating molecular forms of these peptides have been the subject of intense investigation particularly since these analytes are measured in clinical assays. Conflicting data has been reported and no firm consensus on the exact nature of the molecular species exists. Because these clinical assays are immunoassay-based, specific epitopes are detected. It is conceivable then that certain epitopes may be masked and therefore unavailable for antibody binding, thus the importance of determining the nature of the circulating molecular forms of these analytes. This situation is an unavoidable Achilles' heel of immunoassays in general.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 B型亚替肽肽（NT-ProBNP）和ProbNP的N末端片段用作心肌功能障碍的金标准临床标记，例如心脏肥大和左心室心力衰竭。这些肽的实际循环分子形式已成为严格研究的主题，特别是因为在临床测定中测量了这些分析物。已经报道了相互矛盾的数据，并且对分子物种的确切性质没有牢固的共识。由于这些临床测定是基于免疫测定的，因此检测到特定的表位。可以想象，某些表位可能被掩盖，因此无法用于抗体结合，因此确定这些分析物的循环分子形式的性质的重要性。总体而言，这种情况是不可避免的Achilles脚跟。