A GLYCOSYLATED FORM OF THE HUMAN CARDIAC HORMONE PRO B-TYPE NATRIURETIC PEPTIDE

人类心脏激素 PRO B 型钠尿肽的糖基化形式

• 批准号: 8168748
• 负责人: Daniel B. Crimmins
• 金额: $ 1.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168748
• 关键词: Antibodies; Binding; Biological Assay; Brain natriuretic peptide; Cardiac; Clinical; Clinical Markers; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Consensus; Data; Epitopes; Funding; Gold; Grant; Heart Hypertrophy; Heart failure; Heel; Hormones; Human; Immunoassay; Institution; Investigation; Left ventricular structure; Masks; Measures; Molecular; Myocardial dysfunction; N-terminal; Natriuretic Peptides; Nature; Peptides; Reporting; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) and proBNP are used as gold standard clinical markers of myocardial dysfunction such as cardiac hypertrophy and left ventricle heart failure. The actual circulating molecular forms of these peptides have been the subject of intense investigation particularly since these analytes are measured in clinical assays. Conflicting data has been reported and no firm consensus on the exact nature of the molecular species exists. Because these clinical assays are immunoassay-based, specific epitopes are detected. It is conceivable then that certain epitopes may be masked and therefore unavailable for antibody binding, thus the importance of determining the nature of the circulating molecular forms of these analytes. This situation is an unavoidable Achilles' heel of immunoassays in general.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 B型利钠肽原的N末端片段（NT-proBNP）和proBNP被用作心脏肥大和左心室心力衰竭等心肌功能障碍的金标准临床标志物。这些肽的实际循环分子形式一直是深入研究的主题，特别是因为这些分析物是在临床测定中测量的。已报告了验证数据，但对分子种类的确切性质尚无明确的共识。因为这些临床测定是基于免疫测定的，所以检测特异性表位。因此可以想象，某些表位可能被掩蔽，因此不可用于抗体结合，因此确定这些分析物的循环分子形式的性质是重要的。这种情况通常是免疫测定不可避免的阿喀琉斯之踵。