THE BACILLUS ANTHRACIS PROTEIN MPRF IS REQUIRED FOR SYNTHESIS

合成需要炭疽杆菌蛋白 MPRF

• 批准号: 8168808
• 负责人: Shalaka Samant
• 金额: $ 1.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168808
• 关键词: Alveolar Macrophages; Anthrax disease; Antimicrobial Cationic Peptides; Bacillus anthracis; Bacteremia; Blood Circulation; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic Determinism; Grant; Immune response; Infection; Institution; Peptides; Proteins; Research; Research Personnel; Resistance; Resources; Source; Staging; United States National Institutes of Health; extracellular; immune function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During inhalational anthrax, Bacillus anthracis survives and replicates in alveolar macrophages, followed by rapid invasion into the host's bloodstream, where it multiplies to cause heavy bacteremia. B. anthracis must therefore defend itself from host immune functions encountered during both the intracellular and the extracellular stages of anthrax infection. In both of these niches, cationic antimicrobial peptides are an essential component of the host's innate immune response that targets B. anthracis. However, the genetic determinants of B. anthracis contributing to resistance to these peptides are largely unknown.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在吸入性炭疽期间，炭疽杆菌在肺泡巨噬细胞中存活并复制，然后迅速侵入宿主的血液，在那里繁殖并导致严重的菌血症。因此，炭疽杆菌必须防御在炭疽感染的胞内和胞外阶段所遇到的宿主免疫功能。在这两个利基中，阳离子抗菌肽是宿主针对炭疽杆菌的先天免疫反应的重要组成部分。然而，炭疽杆菌对这些多肽产生抗性的遗传决定因素在很大程度上是未知的。