THE BACILLUS ANTHRACIS PROTEIN MPRF IS REQUIRED FOR SYNTHESIS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在吸入性炭疽病期间，炭疽杆菌在肺泡巨噬细胞中存活和复制，随后迅速侵入宿主的血液，在那里繁殖引起严重的菌血症。B。因此，炭疽必须保护自身免受炭疽感染的细胞内和细胞外阶段期间遇到的宿主免疫功能的影响。在这两个小生境中，阳离子抗微生物肽是宿主靶向B的先天免疫应答的重要组分。炭疽病然而，B.导致对这些肽的抗性的炭疽菌在很大程度上是未知的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During inhalational anthrax, Bacillus anthracis survives and replicates in alveolar macrophages, followed by rapid invasion into the host's bloodstream, where it multiplies to cause heavy bacteremia. B. anthracis must therefore defend itself from host immune functions encountered during both the intracellular and the extracellular stages of anthrax infection. In both of these niches, cationic antimicrobial peptides are an essential component of the host's innate immune response that targets B. anthracis. However, the genetic determinants of B. anthracis contributing to resistance to these peptides are largely unknown.