THE BACILLUS ANTHRACIS PROTEIN MPRF IS REQUIRED FOR SYNTHESIS

合成需要炭疽杆菌蛋白 MPRF

• 批准号: 8361404
• 负责人: Shalaka Samant
• 金额: $ 1.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361404
• 关键词: Alveolar Macrophages; Anthrax disease; Antimicrobial Cationic Peptides; Bacillus anthracis; Bacteremia; Blood Circulation; Funding; Genetic Determinism; Grant; Immune response; Infection; Mass Spectrum Analysis; National Center for Research Resources; Peptides; Principal Investigator; Proteins; Research; Research Infrastructure; Resistance; Resources; Source; Staging; United States National Institutes of Health; biomedical resource; cost; extracellular; immune function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During inhalational anthrax, Bacillus anthracis survives and replicates in alveolar macrophages, followed by rapid invasion into the host's bloodstream, where it multiplies to cause heavy bacteremia. B. anthracis must therefore defend itself from host immune functions encountered during both the intracellular and the extracellular stages of anthrax infection. In both of these niches, cationic antimicrobial peptides are an essential component of the host's innate immune response that targets B. anthracis. However, the genetic determinants of B. anthracis contributing to resistance to these peptides are largely unknown.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在吸入性炭疽期间，炭疽杆菌在肺泡巨噬细胞中存活并复制，然后迅速侵入宿主的血液，在那里繁殖并导致严重的菌血症。因此，炭疽杆菌必须防御在炭疽感染的胞内和胞外阶段所遇到的宿主免疫功能。在这两个利基中，阳离子抗菌肽是宿主针对炭疽杆菌的先天免疫反应的重要组成部分。然而，炭疽杆菌对这些多肽产生抗性的遗传决定因素在很大程度上是未知的。