H-MAGNETIC RESONANCE SPECTROSCOPY FOR QUANTIFYING MYOCARDIAL LIPID

用于量化心肌脂质的 H 磁共振波谱

• 批准号: 8168820
• 负责人: ROBERT O'CONNER
• 金额: $ 1.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168820
• 关键词: 1,2-diacylglycerol; Animal Model; Apoptosis; Cardiac; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diglycerides; Disease; Functional disorder; Funding; Glycerides; Grant; Heart; Human; Institution; Insulin Resistance; Lipids; Liver; Magnetic Resonance Spectroscopy; Measures; Monoglycerides; Myocardial; Nonesterified Fatty Acids; Research; Research Personnel; Resources; Risk; Serum; Skeletal Muscle; Source; Syndrome; Techniques; Tissues; Triglycerides; United States National Institutes of Health; fatty acid transport

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elevated serum free fatty acid (FFA) levels are common in people at risk for cardiometabolic syndrome. These FFA are transported, converted, and stored as monoglycerides, diglycerides, and triglycerides in nonadipose tissues including liver, skeletal muscle, and heart. For the heart, this lipid accumulation has been associated with insulin resistance, diabetes, systolic dysfunction, and in animal models, apoptosis.17 However, the relationship between FFA, cardiometabolic syndrome, and cardiovascular disease is unclear and the correlations imperfect. In contrast to FFA levels, a direct measure of cardiac intramyocellular lipid (IMCL) content provides a clear indicator of ectopic lipid accumulation and may provide a better risk predictor for disease. Here we describe and demonstrate a 1H magnetic resonance spectroscopy (MRS) technique for quantifying human myocardial lipid content.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 血清游离脂肪酸（FFA）水平升高， 常见于心脏代谢风险人群 综合征这些FFA被运输，转换， 并以甘油单酯、甘油二酯和 包括肝脏在内的非脂肪组织中的甘油三酯， 骨骼肌和心脏。对于心脏，这 脂质积聚与胰岛素有关 阻力，糖尿病，收缩功能障碍， 在动物模型中，7然而， FFA与心脏代谢综合征 和心血管疾病还不清楚， 相关性不完美。与FFA水平相比， 直接测量心脏肌细胞内 脂质（IMCL）含量提供了一个明确的指标， 异位脂质积聚，并可能提供 更好的疾病风险预测。这里我们描述 并展示了1H核磁共振光谱 (MRS)用于量化人类的技术 心肌脂质含量