analysis core - NINDS INSTIUTIONAL CENTER CORE GRANTS TO SUPPORT NEUROSCIENCE RES

在过去的五年中，NCCBI支持了一组被称为“4dfp套件”的软件工具的广泛扩展和文档编制。这些程序以4dfp(或4维浮点)格式(x，y，z，time)读取和写入图像数据。用于图像数据的4dfp格式最初是在1996年在WU定义的，除了某些头结构之外，它与最近的NlfTI格式(htpp：//nifti.nimh.nih.gov)非常相似。4dfp套件包括一组广泛的二进制可执行文件和外壳脚本(在Unix或Linux下运行)，它们执行关键的图像代数和分析操作，例如过滤、配准、掩码等。 用户可选择在到达CNDA后立即对所有适当数据进行预处理(例如，将重建数据从DICOM转换为分析软件使用的格式)。所有的预处理工作都将由分析核心工作人员进行监督。按照指导委员会的指示，分析核心工作人员程序员将根据需要对4dfp套前处理软件进行改进和修改，以支持调查人员的具体需要。此外，虽然本提案中的大部分内容涉及4dfp程序，但我们也将支持已建立的外部包(例如，SPM、FSL、Freesurfer和Afni)。最后，NCCBI用户的一个主要优势是，那些选择创建自己的脚本的专家用户也可以使用NCCBI管道调用的所有可执行文件。 虽然目标非常广泛，而且几乎所有上述目标都将在下一个供资周期的头两年开始推进，但分析核心的资源将是可观的，特别是考虑到华盛顿大学将提供的额外资金和资源。这一核心的优势将是识别价值的能力；在新的成像方法到达外地并根据指导委员会的建议，投入资源在我们的投资组合中实施这些方法。这样，我们相信NCCBI分析核心的建立将大大受益 我们机构的神经科学研究。我们NINDS资助的许多用户，如下所列，否则将没有实际手段来扩大或优化他们的研究议程中的研究成像。其他在成像方面更有经验的用户将能够通过在新的方向上扩展他们的成像研究来极大地增强他们的科学能力。

In the last five years the NCCBI has supported the extensive expansion and documentation of a group of software tools termed the "4dfp suite". These programs read and write image data in 4dfp (or 4-dimensional floating point) format (x, y, z, time). The 4dfp format for image data was initially defined at WU in 1996 and is very similar to the more recent NlfTI format (htpp://nifti.nimh.nih.gov) except for certain header structures. The 4dfp suite includes an extensive set of binary executables and shell scripts (running under UNIX or Linux) that perform critical image algebra and analysis operations, e.g., filtering, registration, masking, etc. We will offer users the option of having all appropriate data undergo preprocessing immediately upon arrival at the CNDA (e.g., conversion of the reconstructed data from DICOM to the format used by the analysis software). All preprocessing will be monitored by the Analysis Core staff. As directed by the Steering Committee, the 4dfp suite of preprocessing software will be enhanced and modified by the Analysis Core staff programmers as necessary to support the specific needs of investigators. In addition, while most of what follows in this proposal refers to 4dfp procedures, we will also support established external packages (e.g., SPM, FSL, Freesurfer, and AFNI). Finally, a major advantage for NCCBI users is that all executables invoked by NCCBI pipelines are also available to those expert users who choose to create their own scripts. While the objectives are extremely broad and movement on nearly all the goals listed above will begin in the first two years of this next funding cycle, the resources of the Analysis Core will be considerable, especially when the additional funds and resources to be provided by Washington University are considered. A strength of this Core will be the ability to identify value; in new imaging methods as they arrive in the field and with the recommendation of the Steering Committee, commit resources for implementing these methods in our portfolio. IN this way we believe that establishment of the NCCBI Analysis Core will substantially benefit neuroscience research at our institution. Many of our NINDS funded users, listed below, would otherwise have no practical means of expanding, or optimizing, research imaging within their research agenda. Other users more established in imaging will be able to greatly augment their science by expanding their imaging research in new directions.