sites - The NINDS International Stroke Genetics Consortium Study

网站 - NINDS 国际中风遗传学联盟研究

• 批准号: 8046525
• 负责人: STEVEN J KITTNER
• 金额: $ 280.14万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8046525
• 关键词: Acute; Address; Affect; Age of Onset; Aging; Baltimore; Brain; Cardiovascular system; Cause of Death; Cohort Studies; Collaborations; Complex; Computer Simulation; DNA; Data; Data Set; Disease; Documentation; Ensure; Epidemiology; Ethnic Origin; Ethnic group; Functional disorder; Funding Opportunities; Future; Gender; Genes; Genetic; Genetic Variation; Genome; Genomics; Genotype; Goals; Health; Heart; Hereditary Disease; Human Genetics; Individual; Instruction; International; Investigation; Investments; Ischemic Stroke; Kentucky; Meta-Analysis; National Institute of Neurological Disorders and Stroke; National Research Council; Nurses' Health Study; Outcome Study; Pathway interactions; Patients; Phenotype; Play; Policies; Population; Predisposition; Prevention; Race; Reasons for Geographic And Racial Differences in Stroke; Research; Risk; Role; Sample Size; Sampling; Scientist; Siblings; Site; Staging; Stroke; Testing; Trust; Variant; Vascular Diseases; Washington; Women' s Health; base; case control; cohort; database of Genotypes and Phenotypes; disability; epidemiology study; genome wide association study; genome-wide; innovation; member; neuroimaging; novel; response; treatment strategy

PROJECT SUMMARY (See instructions): The long-term objective of this application is to characterize the genetic basis for stroke susceptibility in order to develop more effective prevention and treatment strategies. Our study will thoroughly test the hypothesis that common variants play a major role in stroke, setting the stage for the future genetic study of this disease. This proposal builds on the innovative collaborative network established by the International Stroke Genetics Consortium (ISGC). For the present proposal, ISGC members from the USA have formed a smaller consortium, which includes the following studies: Baltimore-Washington Young Stroke Study, Siblings with Ischemic Stroke Study, Ischemic Stroke Genetics Study, Greater Cincinnati/Northern Kentucky Stroke Study, Northern Manhattan Study, Genes Affecting Stroke Risk and Outcome Study/Bugher Network Study, Heart and Vascular Health Stroke Study, Reasons for Geographic and Racial Differences in Stroke, Nurses Health Study, and Women's Health Initiative. Our specific aims are to: 1. Assemble ischemic stroke phenotypic data and either high quality DNA samples or genotype data from 10 stroke studies with access to 7,033 cases of ischemic stroke and 23,411 study-specific controls. Phenotype data will be harmonized and new genome-wide genotyping will be performed on an estimated 4,420 cases and 3,277 controls. 2. Test for associations with ischemic stroke, rigorously categorized according to subtypes, within this 10-study consortium. Study-specific analyses will be performed and these results will be combined for a metaanalysis of ischemic stroke and its subtypes, with secondary analyses addressing subpopulations, including race/ethnicity, gender, and age of onset. 3. Replicate and extend associations detected in Aim 2 above by taking advantage of other genome-wide association studies conducted by members of the ISGC, including the Wellcome Trust Case-Control Consortium, the Australian National Research Council Study, and the Cohorts for Heart and Aging Research in Genomic Epidemiology.

项目概述（见说明）：