Annual Conference on Development of Robust Experimental Assay Methods (DREAM)

描述（由申请人提供）：药物发现过程是一个寻找具有生物活性分子的漫长旅程，目前只有粗略的地图可供指导。早期发现失败的教训很少被记录下来。由于诸如美国国立卫生研究院分子图书馆倡议等举措在学术筛选方面的增长，制药科学家现在已经重新进入公共部门科学，并能够分享他们的专业知识和知识。DREAM（稳健实验分析方法的发展）会议的目的是建立一个论坛，让这些专家可以交流思想，重要的经验教训，并组织知识和协议，以指导在药物发现过程的早期阶段采用的发现分析。这些早期阶段的分析对整个药物发现过程至关重要，因为它们通常为后续的SAR工作设定指南。Stan Fields在2001年的《科学》杂志上发表的一篇关于人类基因组中的蛋白质组学的文章中清楚地阐述了对改进自动发现分析的迫切需要。“对于一个充斥着各种新奇方法的领域来说，蛋白质组学的首要需求可能是新技术，这令人震惊。目前还没有足够多的检测方法能够实现对基因组价值的蛋白质进行必要的自动化检测。”

DESCRIPTION (provided by applicant): The drug discovery process is a long journey of finding molecules with biological activity, and currently only crude maps are available for guidance. Lessons from failures in early discovery are rarely recorded. Due to growth in academic screening through initiatives such as the NIH Molecular Libraries Initiative, pharmaceutical scientists have now re-entered public sector science and are able to share their expertise and knowledge. The purpose of the DREAM (Development of Robust Experimental Assay Methods) conference is to establish a forum where such experts can exchange ideas, critical lesson learned, and organize knowledge and protocols in to a guide for discovery assays employed in the early phases of the drug discovery process. These early phase assays are critical to the entire drug discovery process as they often set the compass that guides subsequent SAR efforts. The urgent need for improved automated discovery assays was clearly articulated by Stan Fields in an article on proteomics in the Human Genome of issue of Science in 2001. "For a field so laden with razzmatazz methods, it is striking that the number one need in proteomics may be new technology. There are simply not enough assays that are sufficiently streamlined to allow the automation necessary to perform them on a genome's worth of proteins." PUBLIC HEALTH RELEVANCE: The DREAM conference will be a unique forum to convene editors & international subject matter experts in chemical biology & drug discovery to review existing content and solicit new content to the Assay Guidance Manual currently available on the NCGC website.