NICHD Maternal Fetal Medicine Units Network

描述(由申请人提供)：妇女和婴儿医院(WIH)和布朗大学医学院妇产科在其第一个供资周期中实现了对母婴医学股网络的高度参与。WIH MFM单元在登记的患者数量方面位居网络单元的前一半，在可登记的患者比率和数据质量方面位居前三分之一。世界卫生组织表现出了部门和机构对MFMU网络的高度承诺，提供了大量的空间和基础设施支持，并维持了一些协议中出现的收入不足，以优化该股的网络功能。该司在过去和现在由美国国立卫生研究院资助的多机构观察试验(快速胎儿超声对非整倍体风险的研究(已完成)、高血糖和不良妊娠结局研究和死胎合作研究网络研究仍在进行中)中也做得很好。MFM单位在一个地点(WIH)运作，每年生产超过9500名新生儿，是全国最大的单位之一。WIH产科病人的种族/民族分布、经济状况和医疗特征反映了罗德岛的情况，因为WIH占州出生的71%以上。WIH患者的代表性有利于网络研究结果的概括性。WIH患者表现出预期的基于人群的临床特征。WIH患者具有种族多样性，其中66%是白人，9%是黑人，4%是亚洲人。在14%的WIH患者中发现了拉美裔种族认同。超过50%的WIH分娩存在生物危险因素，如糖尿病(8.9%)、早产(5.8%)、高血压疾病(11.6%)、哮喘(4.5%)和多胎妊娠(2.4%)。此外，社会风险因素，如出生时未婚(38%)、18岁以下(3%)和未参保(10%)，使人们有机会解决基于社会差异和生物学的假设。WIH MFM部队很强大。该司由6名MFM医生组成，其中3人接受过流行病学研究培训。该司拥有一支积极进取、卓有成效的研究护士群体，他们表现出高度的适应能力。威斯康星大学也是新生儿研究网络的一个单位。这些特点使布朗/妇女和婴儿股成为资金更新的理想候选者。

DESCRIPTION (provided by applicant): Women and Infants Hospital (WIH) and the Ob/Gyn Department at Brown University Medical School have achieved a high level of participation in the Maternal-Fetal Medicine Units Network during its first funding cycle. The WIH MFM Unit, has ranked in the top half of Network Units in number of enlisted patients and in the top third with respect to enlistedielligible patient ratio and data quality. WIH has demonstrated a high degree of departmental and institutional commitment to the MFMU Network, providing significant space and infrastructure support and sustaining revenue shortfalls that have occurred in some protocols in order to optimize this Unit's functionality for the Network. The Division has also performed well in past and present NIH-funded multi-institutional observational trails (the FaSTER fetal sonography study of aneuploidy risk (completed), the Hyperglycemia and Adverse Pregnancy Outcome and the Stillbirth Cooperative Research Network studies, still ongoing. The MFM Unit operates on one site (WIH), productive of over 9500 annual births, one of the Nation's largest. The racial/ethnic distribution, economic status, and medical characteristics among WIH obstetrical patients mirror those of Rhode Island, insofar as WIH accounts for more than 71% of State births. The representative nature of WIH patients facilitates the generalizability of Network study findings. The WIH patients demonstrate expected population-based clinical characteristics. WIH patients are racially diverse with 66% white, 9% black, and 4% Asian. Hispanic ethnic identity is found in 14% of WIH patients. Biological risk factors such as diabetes (8.9%), premature birth (5.8%), hypertensive disorders (11.6%), asthma (4.5%) and multifetal pregnancy (2.4%) are found in over 50% of WIH deliveries. Moreover, social risk factors such as being unmarried (38%), under 18 years old (3%) and uninsured (10%) at time of birth admission allow opportunity to address hypotheses based on social disparity as well as biology. The WIH MFM Unit is strong. The Division is composed of six MFM physicians, three of whom have epidemiologic research training. The Division has a highly motivated and effect group of research nurses who have demonstrated a high degree of adaptability. WIH is also home to a Unit of the Neonatal Research Network. These attributes make the Brown/Women & Infants Unit a desirable candidate for funding renewal.