NICHD Maternal-Fetal Medicine Units (MFMU) Network

NICHD 母胎医学中心 (MFMU) 网络

• 批准号: 9906244
• 负责人: DWIGHT J ROUSE
• 金额: $ 27.64万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-03 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906244
• 关键词: Advocacy; Area; Birth; Clinical; Clinical Trials; Country; Data; Data Analyses; Data Collection; Discipline of obstetrics; Ensure; Evaluation; Extramural Activities; Funding; Gestational Diabetes; Goals; Gold; Growth; Gynecology; Health; Hospitals; Individual; Infant; Inositol; Joints; Journals; Low Birth Weight Infant; Manuscripts; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical; Mentorship; Meta-Analysis; Mission; National Institute of Child Health and Human Development; Nurses; Positioning Attribute; Pregnancy Complications; Premature Birth; Preparation; Prevention; Production; Productivity; Protocols documentation; Publications; Quality of Care; Randomized Clinical Trials; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Rhode Island; Steroids; Stress; Supplementation; Time; Universities; Voting; Woman; Work; antenatal; congenital cytomegalovirus; data quality; experience; follow-up; medical complication; medical schools; meetings; member; obstetrical complication; premature; prevent; protocol development; public health relevance; randomized placebo controlled trial; randomized trial; recruit; secondary analysis; support network; working group

 DESCRIPTION (provided by applicant): The Division of Maternal-Fetal Medicine at Brown University/Women & Infants Hospital of Rhode Island (WIH) has a strong commitment to a continued high-level of participation in the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network for the purpose of investigating problems in clinical obstetrics, particularly those related to prevention of preterm birth, low birth weight, and obstetrical and medical complications of pregnancy. We have extensive experience in performing clinical trials in these areas, and a strong, stable, and proven research infrastructure. WIH, with ~8,500 annual births, is one of the largest stand- alone obstetric units in the country. We have been a participating center for the past three 5-year cycles of the MFMU Network. We remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years. Since assuming the Brown/WIH PI position in 2009, Dr. Dwight Rouse, along with Dr. Brenna Hughes as Alternate-PI, has endeavored to make Brown/WIH a Network leader, and has been increasingly successful. In the recently completed Network trial "Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial" we were tied for 2nd among all Network centers for recruitment, and in the two actively-recruiting Network randomized trials--"ARRIVE (A Randomized Trial of Induction Versus Expectant Management)" and "A Randomized Trial to Prevent Congenital Cytomegalovirus" -- we rank 3rd. Dr. Hughes leads the latter as sub-committee PI, i.e., she is the overall Network PI of the trial. This cycle, Brown/WIH investigator Dr. Erika Werner, with the joint mentorship of Drs. Rouse and Hughes, as well as Dr. Donald Coustan, presented as a concept and took through to a fully approved protocol (by a vote of 16-0) her proposal for a Network randomized trial of myo-inositol supplementation to prevent gestational diabetes. This protocol will be considered for prioritization at the next prioritization meeting. She also is a member of the Network Meta-Analysis Working Group. That is, in the current Network cycle, we have gone from being a mediocre center to one that leads in scientific and recruitment contributions. We have an experienced, competent, and enthusiastic research team in place, and are confident that our team can help the MFMU Network reach its fullest potential.

 描述（申请人提供）：布朗大学/罗得岛妇女与婴儿医院（WIH）的母胎医学部坚定地致力于继续高水平地参与Eunice Kennedy Shriver NICHD母胎医学单位（MFMU）网络，以调查临床产科问题，特别是与预防早产，低出生体重，以及妊娠的产科和内科并发症。我们在这些领域的临床试验方面拥有丰富的经验，以及强大、稳定和经过验证的研究基础设施。妇女保健所每年约有8,500名新生儿，是全国最大的独立产科单位之一。我们一直是MFMU网络过去三个五年周期的参与中心。在未来五年内，我们作为NICHD MFMU网络中心的竞争性更新仍然处于有利地位。自2009年担任Brown/WIH PI职位以来，德怀特劳斯博士与Brenna Hughes博士沿着担任替代PI，一直致力于使Brown/WIH成为网络领导者，并取得了越来越大的成功。在最近完成的网络试验“产后晚期早产类固醇（ALPS）：一项随机安慰剂对照试验”中，我们在所有网络中心的招募中并列第二，在两项积极招募的网络随机试验中-“ARRIVE（诱导与期待治疗的随机试验）”和“预防先天性巨细胞病毒的随机试验”-我们排名第三。休斯博士作为PI小组委员会领导后者，即，她是试验的总网络PI。这个周期，布朗/WIH 研究员Erika Werner博士在Rouse和Hughes博士以及Donald Coustan博士的共同指导下，提出了一个概念，并通过了一项完全批准的方案（以16-0的投票结果），她提出了一项关于补充肌醇预防妊娠期糖尿病的网络随机试验的建议。将在下一次优先级会议上考虑对本方案进行优先级排序。她也是网络荟萃分析工作组的成员。也就是说，在当前的网络周期中，我们已经从一个平庸的中心变成了一个在科学和招聘贡献方面领先的中心。我们有一个经验丰富，有能力和热情的研究团队，并有信心，我们的团队可以帮助MFMU网络发挥其最大的潜力。