NICHD Maternal-Fetal Medicine Units (MFMU) Network

NICHD 母胎医学中心 (MFMU) 网络

• 批准号: 9243277
• 负责人: DWIGHT J ROUSE
• 金额: $ 29.77万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-03 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9243277
• 关键词: Advocacy; Area; Birth; Clinical; Clinical Trials; Country; Data Analyses; Data Collection; Data Quality; Discipline of obstetrics; Ensure; Evaluation; Extramural Activities; Funding; Gestational Diabetes; Goals; Gold; Growth; Gynecology; Health; Hospitals; Individual; Infant; Inositol; Joints; Journals; Low Birth Weight Infant; Manuscripts; Maternal-Fetal Medicine Units Network; Medical; Mentorship; Meta-Analysis; Mission; National Institute of Child Health and Human Development; Nurses; Positioning Attribute; Pregnancy Complications; Premature Birth; Preparation; Prevention; Production; Productivity; Protocols documentation; Publications; Quality of Care; Randomized Clinical Trials; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Rhode Island; Steroids; Stress; Supplementation; Time; Universities; Voting; Woman; Work; antenatal; congenital cytomegalovirus; experience; fetal medicine; follow-up; medical complication; medical schools; meetings; member; premature; prevent; protocol development; public health relevance; randomized placebo controlled trial; randomized trial; secondary analysis; support network; working group

 DESCRIPTION (provided by applicant): The Division of Maternal-Fetal Medicine at Brown University/Women & Infants Hospital of Rhode Island (WIH) has a strong commitment to a continued high-level of participation in the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units (MFMU) Network for the purpose of investigating problems in clinical obstetrics, particularly those related to prevention of preterm birth, low birth weight, and obstetrical and medical complications of pregnancy. We have extensive experience in performing clinical trials in these areas, and a strong, stable, and proven research infrastructure. WIH, with ~8,500 annual births, is one of the largest stand- alone obstetric units in the country. We have been a participating center for the past three 5-year cycles of the MFMU Network. We remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years. Since assuming the Brown/WIH PI position in 2009, Dr. Dwight Rouse, along with Dr. Brenna Hughes as Alternate-PI, has endeavored to make Brown/WIH a Network leader, and has been increasingly successful. In the recently completed Network trial "Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial" we were tied for 2nd among all Network centers for recruitment, and in the two actively-recruiting Network randomized trials--"ARRIVE (A Randomized Trial of Induction Versus Expectant Management)" and "A Randomized Trial to Prevent Congenital Cytomegalovirus" -- we rank 3rd. Dr. Hughes leads the latter as sub-committee PI, i.e., she is the overall Network PI of the trial. This cycle, Brown/WIH investigator Dr. Erika Werner, with the joint mentorship of Drs. Rouse and Hughes, as well as Dr. Donald Coustan, presented as a concept and took through to a fully approved protocol (by a vote of 16-0) her proposal for a Network randomized trial of myo-inositol supplementation to prevent gestational diabetes. This protocol will be considered for prioritization at the next prioritization meeting. She also is a member of the Network Meta-Analysis Working Group. That is, in the current Network cycle, we have gone from being a mediocre center to one that leads in scientific and recruitment contributions. We have an experienced, competent, and enthusiastic research team in place, and are confident that our team can help the MFMU Network reach its fullest potential.

 描述（由申请人提供）：布朗大学/罗德岛妇婴医院 (WIH) 母胎医学科坚定地致力于继续高水平参与尤尼斯·肯尼迪·施赖弗 NICHD 母胎医学单位 (MFMU) 网络，以调查临床产科问题，特别是与预防早产、低出生体重以及妊娠产科和医学并发症相关的问题。我们在这些领域进行临床试验方面拥有丰富的经验，以及强大、稳定且经过验证的研究基础设施。 WIH 每年约有 8,500 名新生儿出生，是该国最大的独立产科单位之一。我们一直是 MFMU 网络过去三个 5 年周期的参与中心。作为 NICHD MFMU 网络中心，我们在未来五年内仍处于竞争更新的有利地位。自 2009 年担任 Brown/WIH PI 职位以来，Dwight Rouse 博士与候补 PI 的 Brenna Hughes 博士一起努力使 Brown/WIH 成为网络领导者，并取得了越来越大的成功。在最近完成的网络试验“产前晚期早产类固醇（ALPS）：随机安慰剂对照试验”中，我们在所有招募网络中心中并列第二，在两项积极招募的网络随机试验中——“ARRIVE（诱导与期待治疗的随机试验）”和“预防先天性巨细胞病毒的随机试验”——我们排名第三。 Hughes 博士作为小组委员会 PI 领导后者，即她是该试验的整体网络 PI。本周期，布朗/WIH 研究员埃里卡维尔纳博士，在博士的联合指导下。 Rouse 和 Hughes 以及 Donald Coustan 博士提出了一个概念，并通过了一项完全批准的方案（以 16 比 0 的投票结果）她关于补充肌醇预防妊娠糖尿病的网络随机试验的提议。该协议将在下次优先级会议上考虑优先级。她还是网络元分析工作组的成员。也就是说，在当前的网络周期中，我们已经从一个平庸的中心转变为在科学和招聘贡献方面处于领先地位的中心。我们拥有一支经验丰富、能力强且充满热情的研究团队，并相信我们的团队能够帮助 MFMU 网络充分发挥其潜力。