Implications of Health and Genetic Literacy for Genomic Medicine
健康和遗传素养对基因组医学的影响
基本信息
- 批准号:8077308
- 负责人:
- 金额:$ 19.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-15 至 2012-09-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAmericanAttitudeAuthorization documentationBackBehaviorClinical ResearchCommunicationCommunication MethodsCommunitiesComparative StudyComprehensionCounselingDataDiseaseEducationEnvironmentFamilyFamily memberFutureGeneticGenomeGenomicsHealthHealth ProfessionalHealth behaviorHealth behavior changeHeart DiseasesIndividualInformation ResourcesLinkMalignant NeoplasmsMeasuresMedicineMethodsModelingMotivationNon-Insulin-Dependent Diabetes MellitusOutcomePamphletsParticipantPatientsPerceptionPersonsPhysiciansPopulationPopulation StudyPre-Post TestsProfessional counselorProviderPublic HealthRandomizedRecording of previous eventsReportingResearchResourcesRiskRisk BehaviorsSeriesServicesSingle Nucleotide PolymorphismSourceSurveysTest ResultTestingTimebehavior changecollegedesigndisorder preventiondisorder riskempoweredexperiencefamily geneticshealth literacyimprovedinformation gatheringinformation seeking behaviorinterestliteracypreferencepreventpublic health relevancerisk perceptionsatisfactiontrend
项目摘要
DESCRIPTION (provided by applicant): Whole genome profiling involves the analysis of thousands of single nucleotide polymorphisms linked to common diseases such as heart disease and cancer to generate a personal genomic risk profile. This service can be purchased directly from several companies without physician authorization or referral and test results are accessible online. Online communication presents a new model to empower users with direct access to personal health information. With its broad range of risk information, genomic profiling holds the promise to prevent disease and promote positive health behaviors leading to significant public health impact. The complexity of information, however, may pose substantial challenges to user comprehension as most Americans rank average to below average for health literacy. As a result, the value of genomic risk information to promote positive health behaviors may go unrealized. A primary source of health information for patients is health professionals, and thus, the impact of not having professionals involved in the delivery and interpretation of genomic risk information warrants exploration. Likewise, although online communication may serve as an effective approach to increase access to genomic risk information, research is needed to assess comprehension, preferences, and need for additional information or counseling resources. This application aims to explore the implications of health and genetic literacy for genomic medicine in regard to genomic profiling and the manner in which risk results are delivered. We propose to conduct a comparative study of communication methods of genomic risk information for Type 2 diabetes. Subjects will be randomized to receive their genomic risk results via an online report or one-on-one session with a genetic counselor. All subjects will complete a series of pre-and post-test surveys to investigate the relationships between health and genetic literacy, comprehension of genomic risk information, and intended or reported health behavior change as well as impact of delivery method for Type 2 diabetes. As one of the first of its kind, this study will also provide valuable data to inform the design of future studies related to genomic risk information. These data will be critical to advancing our understanding of comprehension and utility of genomic risk information, identifying informational needs and enhancing effective risk communication to reduce misinterpretation and encourage positive health behavior change.
PUBLIC HEALTH RELEVANCE: Genomic profiling has the potential to improve disease prevention and promote positive health behaviors and thus, holds significant public health impact. The results of this study will be critical to advancing our understanding of the primary factors influencing comprehension and utility of genomic risk information, to identify informational needs to reduce misinterpretation and encourage positive health behavior change and to enhance effective risk communication strategies.
描述(由申请人提供):全基因组分析涉及分析与心脏病和癌症等常见疾病相关的数千个单核苷酸多态性,以生成个人基因组风险概况。这项服务可以直接从几家公司购买,无需医生授权或转诊,测试结果可以在线获取。在线通信提供了一种新的模式,使用户能够直接访问个人健康信息。由于其广泛的风险信息,基因组分析有望预防疾病和促进积极的健康行为,从而产生重大的公共卫生影响。然而,信息的复杂性可能会对用户的理解构成重大挑战,因为大多数美国人的健康素养排名平均到低于平均水平。因此,基因组风险信息促进积极健康行为的价值可能无法实现。患者健康信息的主要来源是健康专业人员,因此,没有专业人员参与基因组风险信息的传递和解释的影响值得探索。同样,尽管在线交流可能是增加获得基因组风险信息的有效方法,但需要研究来评估理解、偏好以及对额外信息或咨询资源的需求。该应用程序旨在探索健康和遗传素养对基因组医学在基因组分析和风险结果交付方式方面的影响。我们建议对2型糖尿病基因组风险信息的传播方法进行比较研究。受试者将被随机分配,通过在线报告或与遗传顾问进行一对一的会话来接收其基因组风险结果。所有受试者将完成一系列测试前和测试后调查,以调查健康与遗传素养之间的关系,对基因组风险信息的理解,以及预期或报告的健康行为变化以及分娩方式对2型糖尿病的影响。作为同类研究中的第一个,这项研究还将提供有价值的数据,为未来与基因组风险信息相关的研究设计提供信息。这些数据对于促进我们对基因组风险信息的理解和利用,识别信息需求和加强有效的风险沟通以减少误解和鼓励积极的健康行为改变至关重要。
公共卫生关系:基因组分析有可能改善疾病预防和促进积极的健康行为,因此具有重大的公共卫生影响。这项研究的结果将是至关重要的,以促进我们的理解的主要因素影响的理解和效用的基因组风险信息,以确定信息需求,以减少误解,鼓励积极的健康行为的改变,并加强有效的风险沟通策略。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Public trust in genomic risk assessment for type 2 diabetes mellitus.
公众对2型糖尿病的基因组风险评估的信任。
- DOI:10.1007/s10897-013-9674-3
- 发表时间:2014-06
- 期刊:
- 影响因子:1.9
- 作者:Mills, Rachel;Barry, William;Haga, Susanne B.
- 通讯作者:Haga, Susanne B.
Information-seeking and sharing behavior following genomic testing for diabetes risk.
- DOI:10.1007/s10897-014-9736-1
- 发表时间:2015-02
- 期刊:
- 影响因子:1.9
- 作者:Mills, Rachel;Powell, Jill;Barry, William;Haga, Susanne B.
- 通讯作者:Haga, Susanne B.
Genomic counseling: next generation counseling.
- DOI:10.1007/s10897-013-9641-z
- 发表时间:2014-08
- 期刊:
- 影响因子:1.9
- 作者:Mills, Rachel;Haga, Susanne B.
- 通讯作者:Haga, Susanne B.
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Susanne B Haga其他文献
Susanne B Haga的其他文献
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{{ truncateString('Susanne B Haga', 18)}}的其他基金
NHGRI Research Training and Career Development Annual Meeting
NHGRI 研究培训和职业发展年会
- 批准号:
10752551 - 财政年份:2023
- 资助金额:
$ 19.5万 - 项目类别:
NHGRI Research Training and Career Development Annual Meeting
NHGRI 研究培训和职业发展年会
- 批准号:
10461784 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
NHGRI Research Training and Career Development Annual Meeting
NHGRI 研究培训和职业发展年会
- 批准号:
10657680 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
NHGRI Research Training and Career Development Annual Meeting
NHGRI 研究培训和职业发展年会
- 批准号:
10533589 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
Summer Scholars Program in Genome Sciences and Medicine
基因组科学与医学暑期学者计划
- 批准号:
9358641 - 财政年份:2017
- 资助金额:
$ 19.5万 - 项目类别:
Summer Scholars Program in Genome Sciences and Medicine
基因组科学与医学暑期学者计划
- 批准号:
9791357 - 财政年份:2017
- 资助金额:
$ 19.5万 - 项目类别:
Summer Scholars Program in Genome Sciences and Medicine
基因组科学与医学暑期学者计划
- 批准号:
10006329 - 财政年份:2017
- 资助金额:
$ 19.5万 - 项目类别:
Summer Scholars Program in Genome Sciences and Medicine
基因组科学与医学暑期学者计划
- 批准号:
10200109 - 财政年份:2017
- 资助金额:
$ 19.5万 - 项目类别:
Implications of Health and Genetic Literacy for Genomic Medicine
健康和遗传素养对基因组医学的影响
- 批准号:
7849451 - 财政年份:2010
- 资助金额:
$ 19.5万 - 项目类别:
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