Low flow reperfusion after acute myocardial ischemia: when too little is too much

急性心肌缺血后的低流量再灌注:太少就是太多

基本信息

  • 批准号:
    8063598
  • 负责人:
  • 金额:
    $ 33.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-04-19 至 2015-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): In United States almost 6.5 million people are living with coronary heart disease. During episodes of unstable angina, the affected myocardial tissue experiences transient episodes of acute ischemia followed by reperfusion, often at reduced flow rates. The overall goal of the work proposed in this application is to study mechanisms of ischemia and reperfusion arrhythmias from a new perspective: that of connecting local changes in tissue metabolism caused by perturbations in coronary flow to the resulting disturbances in electrical activity. Despite a clear causative link between cardiac muscle metabolism and its electrical activity, surprisingly few studies have attempted to study them together in working heart preparations using fluorescence imaging. The proposed studies aim to fill this gap. Specific Aim 1 is to increase the capabilities of our existing dual imaging system by incorporating 1) a high resolution camera for fast imaging of NADH fluorescence, 2) pulsed ultraviolet light illumination that is gated to the ECG, and 3) hardware and software for a third fluorescence imaging camera. Specific Aim 2 is to implement techniques that will allow arrhythmias resulting from metabolic disturbances to be studied at physiologic temperatures (37oC) using working heart preparations. Specific Aim 3 is to use multi-mode fluorescence imaging to study specific pathologic conditions in working heart preparations of acute ischemic injury and subsequent reperfusion. These conditions include: rapid pacing, fibrillation, low-flow reperfusion, and ischemic preconditioning. With these Aims, we will provide major advances in the methodology required to conduct studies at the intersection of the research fields of coronary flow, cardiac metabolism, and cardiac electrophysiology while also providing the potential to gain improved understanding of the physiology that causes lethal arrhythmias during unstable coronary flow. Ultimately, this will provide new insights into possible therapeutic interventions to prevent sudden cardiac death. PUBLIC HEALTH RELEVANCE: Tachyarrhythmia resulting from acute ischemia and reperfusion within the settings of unstable angina can be deadly as they are the common culprits of sudden cardiac death. The broad goal of our studies is to further understand how the dynamic heterogeneity of tissue metabolism that results from unstable angina breeds arrhythmias. Ultimately, this will provide new insights into possible therapeutic interventions to prevent sudden cardiac death.
描述(申请人提供):在美国,近650万人患有冠心病。在不稳定性心绞痛发作期间,受影响的心肌组织会经历短暂的急性缺血发作,然后再灌流,通常是以较低的流速。本申请中提出的工作的总体目标是从一个新的角度研究缺血和再灌注性心律失常的机制:将冠脉血流扰动引起的组织代谢局部变化与由此导致的电活动障碍联系起来。尽管心肌新陈代谢和其电活动之间存在明显的因果联系,但令人惊讶的是,很少有研究试图在工作心脏准备中使用荧光成像来同时研究它们。拟议的研究旨在填补这一空白。具体目标1是通过采用1)用于快速成像NADH荧光的高分辨率相机、2)通向心电的脉冲紫外光照射以及3)用于第三个荧光成像相机的硬件和软件来增加我们现有的双重成像系统的能力。具体目标2是实施技术,使代谢紊乱引起的心律失常能够在生理温度(37摄氏度)下使用工作心脏制剂进行研究。具体目的3是利用多模式荧光成像技术研究急性缺血损伤和随后再灌注时工作心脏准备的特殊病理情况。这些情况包括:快速起搏、纤颤、低流量再灌注和缺血预适应。有了这些目标,我们将在方法学方面取得重大进展,以便在冠状动脉血流、心脏代谢和心脏电生理学的研究领域进行交叉研究,同时也有可能更好地理解在冠状动脉血流不稳定时导致致命性心律失常的生理学。最终,这将为预防心脏性猝死的可能治疗干预提供新的见解。 公共卫生相关性:不稳定心绞痛环境中的急性缺血和再灌注引起的快速性心律失常可能是致命的,因为它们是心源性猝死的常见罪魁祸首。我们研究的主要目标是进一步了解不稳定心绞痛引起的组织代谢的动态异质性如何导致心律失常。最终,这将为预防心脏性猝死的可能治疗干预提供新的见解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Matthew W. Kay其他文献

Feasibility of Long-Distance Transfer for High Resolution Optical Mapping of Cardiac Tissue Constructs
  • DOI:
    10.1016/j.bpj.2011.11.3677
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Nina Tandon;Luther M. Swift;Matthew W. Kay;Gordana Vunjak-Novakovic;Narine Sarvazyan
  • 通讯作者:
    Narine Sarvazyan
PO-05-140 NADH CATHETER MAPPING IDENTIFIES GAP FORMATION BETWEEN PULSED FIELD ABLATION LESIONS
PO-05-140 NADH 导管测绘识别脉冲场消融病变之间的间隙形成
  • DOI:
    10.1016/j.hrthm.2025.03.1538
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Rebekah Russo;Terry Ransbury;Catherine Ruffino;Bridget Alber;Omar Amirana;Narine Sarvazyan;Matthew W. Kay
  • 通讯作者:
    Matthew W. Kay
The Inter-Dependency of Local Myocardial Metabolism and Epicardial Electrical Activity during Acute Ischemia and Reperfusion
  • DOI:
    10.1016/j.bpj.2009.12.2879
  • 发表时间:
    2010-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Huda Asfour;Luther M. Swift;Alta Berger;Ara Arutunyan;Narine Sarvazyan;Matthew W. Kay
  • 通讯作者:
    Matthew W. Kay
Exploring the Effects of Conduction Reserve and Ephaptic Coupling in Cardiac Cells
  • DOI:
    10.1016/j.bpj.2019.11.2733
  • 发表时间:
    2020-02-07
  • 期刊:
  • 影响因子:
  • 作者:
    Joyce Lin;Steven Poelzing;Sharon A. George;Amara Greer-Short;Matthew W. Kay
  • 通讯作者:
    Matthew W. Kay
MP-470543-008 PANORAMIC HYPERSPECTRAL OPTICAL MAPPING OF CARDIAC MEMBRANE POTENTIAL AND TISSUE TYPE IN INFARCTED HEARTS
MP-470543-008 梗死心脏中心肌膜电位和组织类型的全景高光谱光学映射
  • DOI:
    10.1016/j.hrthm.2024.03.371
  • 发表时间:
    2024-05-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Grant Kowalik;Murray Loew;Emilia Entcheva;Matthew W. Kay
  • 通讯作者:
    Matthew W. Kay

Matthew W. Kay的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Matthew W. Kay', 18)}}的其他基金

Novel Mechanisms that Restore Cardiac Parasympathetic Activity Limits Arrhythmias and Cardiac Dysfunction After Myocardial Infarction
恢复心脏副交感神经活动的新机制可限制心肌梗死后的心律失常和心脏功能障碍
  • 批准号:
    10366054
  • 财政年份:
    2020
  • 资助金额:
    $ 33.47万
  • 项目类别:
Novel Mechanisms that Restore Cardiac Parasympathetic Activity Limits Arrhythmias and Cardiac Dysfunction After Myocardial Infarction
恢复心脏副交感神经活动的新机制可限制心肌梗死后的心律失常和心脏功能障碍
  • 批准号:
    10604331
  • 财政年份:
    2020
  • 资助金额:
    $ 33.47万
  • 项目类别:
Novel Mechanisms that Restore Cardiac Parasympathetic Activity Limits Arrhythmias and Cardiac Dysfunction After Myocardial Infarction
恢复心脏副交感神经活动的新机制可限制心肌梗死后的心律失常和心脏功能障碍
  • 批准号:
    9981104
  • 财政年份:
    2020
  • 资助金额:
    $ 33.47万
  • 项目类别:
Hypothalamic neuron activation to blunt myocardial remodeling during chronic sleep apnea
下丘脑神经元激活可减弱慢性睡眠呼吸暂停期间的心肌重塑
  • 批准号:
    10321896
  • 财政年份:
    2018
  • 资助金额:
    $ 33.47万
  • 项目类别:
Oxygen-rich perfusate that is compatible with optical assessments of myocardial physiology
与心肌生理学光学评估兼容的富氧灌注液
  • 批准号:
    9252529
  • 财政年份:
    2016
  • 资助金额:
    $ 33.47万
  • 项目类别:
Oxygen-rich perfusate that is compatible with optical assessments of myocardial physiology
与心肌生理学光学评估兼容的富氧灌注液
  • 批准号:
    9112060
  • 财政年份:
    2016
  • 资助金额:
    $ 33.47万
  • 项目类别:
Low flow reperfusion after acute myocardial ischemia: when too little is too much
急性心肌缺血后的低流量再灌注:太少就是太多
  • 批准号:
    8454499
  • 财政年份:
    2010
  • 资助金额:
    $ 33.47万
  • 项目类别:
Low flow reperfusion after acute myocardial ischemia: when too little is too much
急性心肌缺血后的低流量再灌注:太少就是太多
  • 批准号:
    8645695
  • 财政年份:
    2010
  • 资助金额:
    $ 33.47万
  • 项目类别:
Low flow reperfusion after acute myocardial ischemia: when too little is too much
急性心肌缺血后的低流量再灌注:太少就是太多
  • 批准号:
    7889518
  • 财政年份:
    2010
  • 资助金额:
    $ 33.47万
  • 项目类别:
Low flow reperfusion after acute myocardial ischemia: when too little is too much
急性心肌缺血后的低流量再灌注:太少就是太多
  • 批准号:
    8238372
  • 财政年份:
    2010
  • 资助金额:
    $ 33.47万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 33.47万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了