Muscle: Excitation/Contraction Coupling Gordon Research Conference

肌肉：兴奋/收缩耦合戈登研究会议

• 批准号: 8254759
• 负责人: Paul D Allen
• 金额: $ 2.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8254759
• 关键词: Affect; Age; Aging; Area; Basic Science; Calcium; Calcium Signaling; Calsequestrin; Cardiac; Cells; Central Core Myopathy; Clinical Research; Contracts; Coupling; Development; Disease; Disease Progression; Environment; Europe; Exercise; Fatigue; Goals; Health; Human; Hypokalemic periodic paralysis; International; Knowledge; Life; Malignant hyperpyrexia due to anesthesia; Measures; Methods; Molecular; Muscle; Mutation; Myopathy; Nuclear; Participant; Process; Proteins; Research; Research Personnel; Role; RyR1; RyR2; SERCA1; Scientist; Signal Transduction; Site; Skeletal Muscle; Switzerland; Time; Timothy syndrome; Translational Research; Triad Acrylic Resin; Ventricular Tachycardia; base; college; disease-causing mutation; experience; human disease; meetings; novel strategies; repaired; response; skeletal; symposium

DESCRIPTION (provided by applicant): Gordon Research Conference on Muscle: Excitation-Contraction Coupling This is a proposal for partial support of the Gordon Research Conference (GRC) on Excitation-Contraction Coupling (ECC) in skeletal muscle, the only national or international meeting with this specific focus. The 2012 conference will be held in Europe at the GRC site in Les Diablerets, Switzerland. Calcium signaling figures importantly in the adaptive responses of healthy muscle to exercise and age mutations in a number central players in the ECC process cause muscle diseases such as: 1. hypokalemic periodic paralysis (skeletal L-type Ca2+ channel (DHPR)) 2. malignant hyperthermia (RyR1, skeletal DHPR) 3. central core disease, multi-mini core disease and centro-nuclear myopathy (RyR1). 4. Brody's disease (SERCA1). 5. Timothy syndrome (Cardiac DHPR). and 5. catecholaminergic polymorphic ventricular tachycardia (RyR2 and Calsequestrin 2). Key to understanding the mechanisms causing these diseases is understanding the affected protein's normal function. In addition to muscle diseases that result from mutations to the proteins that participate in ECC, there are many diseases that result from mutations to proteins that are not directly involved in this process. However, because a disturbance in Ca2+ signaling is part of a pathological cascade that causes muscle damage there is substantial benefit to having these diseases discussed in the ECC Gordon conference. in response to exercise and aging and both are important to human health. In the time since the 2009 ECC Gordon conference, there has been important progress in our understanding of excitation-contraction coupling and other types of calcium signaling in muscle, as well as of the role of calcium in muscle disease, adaptation and repair. It is this progress that provides the basis for our planning of the 2012 Gordon ECC Gordon Conference. We feel confident that the meeting we have planned will stimulate participants to pursue new approaches and research directions in the fields of muscle ECC, calcium signaling and disease. PUBLIC HEALTH RELEVANCE: The goals of the 2012 Muscle: Excitation Contraction Coupling Gordon Research Conference are to discuss and evaluate critically new results related to the basic mechanisms that allow muscle to contract, and how these are affected by fatigue, age and mutations that cause muscle disease. This triennial conference is the only conference devoted to this very important area of medically relevant research and will allow participants who do basic, translational and clinical research to meet and discuss new ways to solve important problems affecting everyone's everyday life.

描述（由申请人提供）：戈登研究会议肌肉：兴奋-收缩耦合这是一个建议，部分支持戈登研究会议（GRC）的兴奋-收缩耦合（ECC）在骨骼肌，唯一的国家或国际会议与此特定的重点。2012年的会议将在欧洲瑞士Les Diablerets的GRC现场举行。钙信号在健康肌肉对运动的适应性反应中起重要作用，ECC过程中许多核心参与者的年龄突变导致肌肉疾病，例如：1.低钾性周期性麻痹（骨骼L型钙通道（DHPR））2.恶性高热（RyR 1，骨骼DHPR）3.中央核心病、多小核心病和中央核肌病（RyR 1）。4. Brody's disease（SERCA1）. 5.蒂莫西综合征（心脏DHPR）。和5.儿茶酚胺能多形性室性心动过速（RyR 2和钙螯合蛋白2）。了解导致这些疾病的机制的关键是了解受影响蛋白质的正常功能。除了由参与ECC的蛋白质突变引起的肌肉疾病外，还有许多疾病是由不直接参与该过程的蛋白质突变引起的。然而，由于Ca 2+信号传导的干扰是导致肌肉损伤的病理级联反应的一部分，因此在ECC戈登会议上讨论这些疾病有很大的好处。对运动和衰老的反应，两者对人类健康都很重要。自2009年ECC Gordon会议以来，我们对肌肉中兴奋-收缩偶联和其他类型的钙信号传导以及钙在肌肉疾病、适应和修复中的作用的理解取得了重要进展。正是这一进展为我们规划2012年戈登ECC戈登会议提供了基础。我们相信，我们计划的会议将激励与会者在肌肉ECC，钙信号和疾病领域寻求新的方法和研究方向。 公共卫生相关性：2012年肌肉：兴奋收缩耦合戈登研究会议的目标是讨论和评估与肌肉收缩的基本机制相关的新结果，以及这些结果如何受到疲劳，年龄和导致肌肉疾病的突变的影响。这个三年一度的会议是唯一一次专门讨论这一非常重要的医学相关研究领域的会议，将允许从事基础、转化和临床研究的参与者会面并讨论解决影响每个人日常生活的重要问题的新方法。