2nd ASM Conference on Manipulation of Nuclear Processes by DNA Viruses

描述(由申请人提供)：长期以来，核内的病毒-宿主相互作用一直被认为在决定病毒感染的过程中发挥着重要作用。DNA病毒，如多瘤病毒、乳头瘤病毒、腺病毒和疱疹病毒与许多相同的宿主细胞途径相互作用，然而，每个病毒家族都进化出独特的策略，以创造有利于病毒基因表达和高效复制的核环境。研究大型DNA病毒的研究人员通常与研究小型DNA病毒的研究人员参加的会议不同。这种会议的分离导致了研究大型DNA病毒(如疱疹)的调查人员不知道小型DNA病毒领域正在做什么的情况，尽管行动模式有共同之处。请拨资金协助部分支助题为“DNA病毒操纵核过程”的会议，这次会议将汇集研究在细胞核内复制的大小DNA病毒的研究人员，讨论共同感兴趣的领域。本次会议将由美国微生物学会(ASM)主办，将于2011年10月23-27日在新墨西哥州圣达菲广场酒店的拉方达酒店举行。这次会议是对2008年在南卡罗来纳州查尔斯顿举行的关于这一主题的上一次会议的后续行动。这是病毒学中的一个重要领域，对病毒的发病机制产生了许多新的和令人兴奋的见解。目前的研究旨在了解DNA病毒如何以各种方式操纵细胞核，包括与DNA修复、蛋白酶体、伴侣和应激反应途径的相互作用。其他工作涉及病毒与宿主转录机制和染色质的相互作用，以及定位于核仁的活动。此外，病毒蛋白与细胞癌基因和肿瘤抑制因子的相互作用对病毒的繁殖和转化也很重要。所有这些主题都将在几次会议中讨论。我们还对新出现的和新类型的宿主-病毒相互作用感到兴奋。例如，DNA病毒通过调节细胞miRNAs的表达来调节细胞通路，并进化出新的策略来克服作用于细胞核的宿主先天性免疫监视机制，这一点变得越来越明显。本次会议将在以下几届会议上讨论上述议题：1)。病毒与DNA修复/重组机制的相互作用2)。病毒和应激反应3)。核病毒重塑和端粒酶激活4)。病毒和癌症5)。转录调控和miRNA调控6)。颠覆细胞核内的先天免疫反应 公共卫生相关性：DNA病毒是许多由感染性病原体引起的疾病的罪魁祸首。大小DNA病毒都操纵细胞核中的细胞过程，以促进它们的生产性生命周期，这有助于各种疾病的发展。ASM主办的题为“DNA病毒对核过程的操纵”的会议将研究大小DNA病毒用于病毒致病的共同机制，并探索该领域令人兴奋的新发现。研究大小DNA病毒的研究人员很少参加聚焦于这一重要主题的共同会议。这次会议是为数不多的将这些研究人员小组聚集在一起，自由分享想法并开发未来合作领域的会议之一。

DESCRIPTION (provided by applicant): Virus-host interactions in the nucleus have long been recognized as playing important roles in determining the course of viral infection. DNA viruses such as Polyoma-, Papilloma-, Adeno- and Herpesviruses interact with many of the same host cell pathways, however, each virus family has evolved unique strategies to create a nuclear environment conducive to viral gene expression and productive replication. Investigators studying large DNA viruses usually attend separate meetings from those attended by researchers studying small DNA viruses. This separation of meetings has resulted in situations where investigators studying large DNA viruses, such as herpes, are unaware of what is being done in the small DNA virus field and vice versa despite commonalities in modes of action. Funds are requested to assist in the partial support of a meeting entitled "Manipulation of Nuclear Processes by DNA Viruses" that will bring together researchers who work on both large and small DNA viruses that replicate in the nucleus to discuss areas of common interest. This meeting will be sponsored by the American Society for Microbiology (ASM) and will be held at the La Fonda on the Plaza Hotel in Santa Fe, New Mexico from October 23-27, 2011. This meeting follows up on a previous meeting on this topic that was held in 2008 in Charleston, SC. This is a significant area in virology that is yielding many new and exciting insights into viral pathogenesis. Current research is aimed at understanding how DNA viruses manipulate the nucleus in various ways including interactions with DNA repair, proteosomal, chaperone and stress response pathways. Additional work addresses viral interactions with the host transcriptional machinery and chromatin as well activities localized to the nucleolus. Furthermore, interactions of viral proteins with cellular oncogenes and tumor suppressors are important for viral propagation as well as transformation. All these topics will be discussed in several sessions. We are also excited about emerging and novel types of host-virus interactions. For instance, it is becoming increasingly clear that DNA viruses modulate the expression of cellular miRNAs to regulate cellular pathways as well as having evolved novel strategies to overcome host innate immune surveillance mechanisms that act in the nucleus. The above topics will be addressed in this meeting in the following sessions: 1). viral interactions with DNA repair/recombination machinery 2). viruses and the stress response 3). viral remodeling of the nucleus and telomerase activation 4). viruses and cancer 5). transcriptional control and miRNA regulation 6). Subversion of the innate immune response in the nucleus PUBLIC HEALTH RELEVANCE: DNA viruses are responsible for many diseases caused by infectious agents. Both large and small DNA viruses manipulate cellular processes in the nucleus to promote their productive life cycles and this contributes to the development of a variety of diseases. The ASM sponsored conference entitled "Manipulation of Nuclear Processes by DNA Viruses" will examine common mechanisms utilized by both large and small DNA viruses for viral pathogenesis and explore exciting new findings in the field. Investigators studying large and small DNA viruses rarely attend a common meeting focused on this important topic. This conference is one of the few that will bring together these groups of investigators to freely share ideas and develop areas of future collaboration.