2nd ASM Conference on Manipulation of Nuclear Processes by DNA Viruses

第二届 ASM 关于 DNA 病毒操纵核过程的会议

• 批准号: 8204189
• 负责人: Laimonis A. LAIMINS
• 金额: $ 1万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8204189
• 关键词: Address; Adenoviruses; American; Area; Cell Cycle; Cell Nucleolus; Cell Nucleus; Cell physiology; Cells; Chromatin; Coffee; Collaborations; DNA Repair; DNA Viruses; Data; Development; Disease; Ensure; Environment; Family; Fostering; Funding; Future; Gene Expression; Genetic Recombination; Genetic Transcription; Government; Herpesviridae; Immune response; Immunologic Surveillance; Infectious Agent; Institution; Life Cycle Stages; Malignant Neoplasms; MicroRNAs; Microbiology; Molecular Chaperones; New Mexico; Nuclear; Oral; Papilloma; Pathway interactions; Play; Polyomavirus; Process; Proto-Oncogenes; Regulation; Regulatory Pathway; Research; Research Personnel; Role; Scientist; Societies; Telomerase; Transcriptional Regulation; Tumor Suppressor Genes; United States; Viral; Viral Genes; Viral Pathogenesis; Viral Proteins; Virus; Virus Diseases; Work; abstracting; biological adaptation to stress; career; design; human disease; insight; interest; meetings; novel; novel strategies; posters; symposium; translational study; virology; virus host interaction

DESCRIPTION (provided by applicant): Virus-host interactions in the nucleus have long been recognized as playing important roles in determining the course of viral infection. DNA viruses such as Polyoma-, Papilloma-, Adeno- and Herpesviruses interact with many of the same host cell pathways, however, each virus family has evolved unique strategies to create a nuclear environment conducive to viral gene expression and productive replication. Investigators studying large DNA viruses usually attend separate meetings from those attended by researchers studying small DNA viruses. This separation of meetings has resulted in situations where investigators studying large DNA viruses, such as herpes, are unaware of what is being done in the small DNA virus field and vice versa despite commonalities in modes of action. Funds are requested to assist in the partial support of a meeting entitled "Manipulation of Nuclear Processes by DNA Viruses" that will bring together researchers who work on both large and small DNA viruses that replicate in the nucleus to discuss areas of common interest. This meeting will be sponsored by the American Society for Microbiology (ASM) and will be held at the La Fonda on the Plaza Hotel in Santa Fe, New Mexico from October 23-27, 2011. This meeting follows up on a previous meeting on this topic that was held in 2008 in Charleston, SC. This is a significant area in virology that is yielding many new and exciting insights into viral pathogenesis. Current research is aimed at understanding how DNA viruses manipulate the nucleus in various ways including interactions with DNA repair, proteosomal, chaperone and stress response pathways. Additional work addresses viral interactions with the host transcriptional machinery and chromatin as well activities localized to the nucleolus. Furthermore, interactions of viral proteins with cellular oncogenes and tumor suppressors are important for viral propagation as well as transformation. All these topics will be discussed in several sessions. We are also excited about emerging and novel types of host-virus interactions. For instance, it is becoming increasingly clear that DNA viruses modulate the expression of cellular miRNAs to regulate cellular pathways as well as having evolved novel strategies to overcome host innate immune surveillance mechanisms that act in the nucleus. The above topics will be addressed in this meeting in the following sessions: 1). viral interactions with DNA repair/recombination machinery 2). viruses and the stress response 3). viral remodeling of the nucleus and telomerase activation 4). viruses and cancer 5). transcriptional control and miRNA regulation 6). Subversion of the innate immune response in the nucleus PUBLIC HEALTH RELEVANCE: DNA viruses are responsible for many diseases caused by infectious agents. Both large and small DNA viruses manipulate cellular processes in the nucleus to promote their productive life cycles and this contributes to the development of a variety of diseases. The ASM sponsored conference entitled "Manipulation of Nuclear Processes by DNA Viruses" will examine common mechanisms utilized by both large and small DNA viruses for viral pathogenesis and explore exciting new findings in the field. Investigators studying large and small DNA viruses rarely attend a common meeting focused on this important topic. This conference is one of the few that will bring together these groups of investigators to freely share ideas and develop areas of future collaboration.

描述（由申请人提供）：细胞核中的病毒-宿主相互作用长期以来被认为在决定病毒感染过程中发挥重要作用。DNA病毒如多瘤病毒、乳头瘤病毒、腺病毒和疱疹病毒与许多相同的宿主细胞途径相互作用，然而，每个病毒家族都进化出独特的策略来创造有利于病毒基因表达和生产性复制的核环境。研究大型DNA病毒的研究人员通常参加与研究小型DNA病毒的研究人员分开的会议。这种会议的分离导致了研究大型DNA病毒（如疱疹病毒）的研究人员不知道小型DNA病毒领域正在做什么的情况，反之亦然，尽管在作用模式上有共同之处。请求提供资金，以协助部分支助一次题为“DNA病毒对核过程的操纵”的会议，该会议将使研究在核中复制的大型和小型DNA病毒的研究人员聚集一堂，讨论共同感兴趣的领域。本次会议将由美国微生物学会（ASM）赞助，并将于2011年10月23日至27日在新墨西哥州圣达菲广场酒店的拉方达举行。本次会议是2008年在南卡罗来纳州查尔斯顿举行的关于这一主题的前一次会议的后续会议。这是病毒学中的一个重要领域，对病毒发病机制产生了许多新的令人兴奋的见解。目前的研究旨在了解DNA病毒如何以各种方式操纵细胞核，包括与DNA修复，蛋白体，伴侣和应激反应途径的相互作用。其他工作涉及病毒与宿主转录机制和染色质的相互作用以及定位于核仁的活动。此外，病毒蛋白与细胞癌基因和肿瘤抑制因子的相互作用对于病毒繁殖和转化是重要的。所有这些主题将在几次会议上讨论。我们还对新出现的新型宿主-病毒相互作用感到兴奋。例如，越来越清楚的是，DNA病毒调节细胞miRNA的表达以调节细胞通路，以及已经进化出克服在细胞核中起作用的宿主先天免疫监视机制的新策略。上述议题将在本次会议的下列会议中讨论：1）。病毒与DNA修复/重组机制的相互作用2）。病毒和应激反应3）。细胞核的病毒重塑和端粒酶活化4）。病毒和癌症5）。转录控制和miRNA调节6）。细胞核内先天免疫反应的颠覆 公共卫生相关性：DNA病毒是由传染性病原体引起的许多疾病的原因。大型和小型DNA病毒都操纵细胞核中的细胞过程，以促进其生产性生命周期，这有助于各种疾病的发展。ASM主办的题为“DNA病毒操纵核过程”的会议将研究大型和小型DNA病毒在病毒发病机制中使用的共同机制，并探索该领域令人兴奋的新发现。研究大型和小型DNA病毒的研究人员很少参加一个专注于这一重要主题的共同会议。这次会议是少数几个将这些研究人员聚集在一起自由分享想法和发展未来合作领域的会议之一。