Structure and Energetics in Mammalian Cells

描述（由申请人提供）：本申请申请资助美国科学家参加一个关于哺乳动物细胞结构和能量学系统生物学的会议，重点是了解肿瘤发展特征的综合细胞功能转变的结构和功能基础。近年来，能量代谢作为癌症表型的核心组成部分的关键作用得到了显著的认识。此外，癌细胞涉及结构-功能关系的重大转变，表明整合细胞功能的基本重新排序。尽管我们对驱动这些和相关转变的关系的理解存在重大差距，但亚细胞结构事件及其能量和代谢影响的大部分详细知识都掌握在没有密切参与疾病研究的研究人员身上。基于这些考虑，在英国生化学会的主持下，将在英国曼彻斯特组织一次国际会议，会议将汇集细胞功能结构和能量方面的专家、主要研究细胞综合功能的系统生物学研究人员和能够将这些观点置于疾病背景下的癌症研究人员。会议形式旨在以一种创新的方式加强讨论，促进来自不同背景和知识基础的研究人员之间的互动和合作，促进和促进他们对理解导致癌症的综合细胞功能变化的贡献。此申请是为参加本次会议的美国研究人员申请旅行奖励。我们将鼓励来自不同研究领域的知名研究人员的申请，他们可以为讨论带来不同的观点，也鼓励来自早期职业研究人员的申请，他们愿意突破现有的范式，为整合疾病中的细胞功能问题开辟新的前景。将特别强调促进女科学家的参与，并鼓励来自处境不利的少数民族的研究人员以及残疾研究人员的参与。

DESCRIPTION (provided by applicant): This application requests funding for travel awards to US-based scientists to attend a conference on the Systems Biology of Structures and Energetics in Mammalian Cells, with a focus on understanding the structural and functional basis for the transitions in integrated cell functions that characterize the development of tumors. Recent years have witnessed a remarkable surge in the recognition of the critical role of energy metabolism as a central constituent of the cancer phenotype. In addition, cancer cells involve major transitions in structure-function relationships that indicate a fundamental re-ordering of the integrated cell function. Although there are major gaps in our understanding of the relationships that drive these and related transitions, much of the detailed knowledge of the subcellular structural events and their energetic and metabolic implications resides with investigators who are not intimately involved in the disease-focused research. Based on these considerations, an international conference will be organized in Manchester, UK, under the auspices of the Biochemical Society of Great Britain, which will bring together investigators who are experts on the structural and energetic aspects of cellular function with systems biology researchers who have a major orientation on integrated cell function and with cancer researchers who can put these perspectives in a disease context. The conference format aims at an innovative approach to enhance discussion and promote interactions and collaborations between investigators from very different backgrounds and knowledge bases, to facilitate and promote their contribution to the understanding of changes in integrative cell function that leads to cancer. This application is to request travel awards for US-based investigators to participate in this conference. Applications will be encouraged from established investigators from diverse areas of research who can bring different perspectives to the discussion, as well as from early career investigators who are willing to break through existing paradigms and open new vistas on the problem of integrating cell function in disease. Particular emphasis will be placed on facilitating the participation of women scientists and encouraging the participation of researchers from disadvantaged minorities as well as investigators with disabilities. PUBLIC HEALTH RELEVANCE: There is much evidence that the transition to the cancer phenotype cannot be adequately described by the deregulation of individual genes or pathways, but requires an understanding of integrated cell function. The conference on Systems Biology of Structures and Energetics in Mammalian Cells aims at bringing together scientists who are specialists in structural and functional aspects of cell function and systems biologist interested in integrative cell function with cancer researchers who understand the disease process. The application requests funding for travel awards to encourage participation of US-based scientists to participate in and contribute to this conference, which is expected to bring novel perspectives to the field of cancer research that may contribute to the development of improved therapies.