权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

2012 AAOS Femoroacetabular Impingement Research Symposium

2012 AAOS股骨髋臼撞击研究研讨会

基本信息

批准号：
8201731
负责人：
JOHN C CLOHISY
金额：
$ 1.5万
依托单位：
AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8201731
关键词：
Academy Adult Affect Age Age-Years American Area Basic Science Cartilage Clinical Clinical Sciences Clinical Trials Communities Consensus Deformity Degenerative polyarthritis Diagnosis Diagnostic Disease Disease Progression Early Diagnosis Education Effectiveness Epidemiology Etiology Femur Foundations Functional disorder Funding Future Government Health Personnel Hip Joint Hip Osteoarthritis Industry Intervention Investigation Joints Journals Knowledge Laboratory Research Lower Extremity Medicine Methodology Modality Musculoskeletal Natural History Operative Surgical Procedures Orthopedics Outcome Outcome Measure Patients Pediatrics Physicians Primary Care Physician Printing Procedures Publications Quality of life Relative (related person)Research Research Design Role Screening procedure Series Sports Staging Surgeon Techniques Therapeutic Intervention Translating Trauma United States acetabulum bone clinical efficacy clinical practice disease characteristic economic value hip replacement arthroplasty improved innovation interdisciplinary approach interest knee replacement arthroplasty loss of function patient population pre-clinical research prevent reconstruction research and development rheumatologist symposium web page

项目摘要

DESCRIPTION (provided by applicant): Osteoarthritis (OA) affects an estimated 30% of Americans over 60 years of age and is one of the leading causes of reduced quality of life and loss of function for orthopaedic patients. Lower extremity OA is particularly common and costly. Estimates show that by 2030, over 4.4 million hip and knee replacement procedures will be performed annually in the United States with the number of hip replacements increasing by 200%. Innovative strategies are needed to more effectively diagnose, prevent and treat OA. Future treatment innovations will focus on early detection of disease and therapeutic interventions to prevent or halt disease progression and preserve the natural hip joint. Over the past decade there have been major advances in elucidating the pathophysiology of hip osteoarthritis. Most importantly, the profound etiological role of femoroacetabular impingement (FAI) has come to the forefront. FAI is characterized by structural deformities of the proximal femur and acetabulum that produce abnormal repetitive abutment along the acetabular rim resulting in excessive loading, acetabular rim cartilage damage and progressive joint degeneration. Patients with FAI present at various ages with diverse stages of disease. Due to the heterogeneous patient population and variability of disease characteristics, treatment of FAI encompasses a variety of musculoskeletal healthcare providers including orthopaedic surgeons (adult reconstruction, pediatrics, sports and trauma), rheumatologists, physiatrists, physical therapists and primary care physicians. Despite the recent interest and technical innovations for the surgical treatment of FAI, there is a major need for basic and clinical investigation in this burgeoning field. Additionally, significant controversy persists regarding the etiologic role of FAI in hip OA, the natural history of FAI, the pathophysiology of FAI, optimal diagnostic and disease staging modalities, the efficacy of different treatment techniques, and the most appropriate clinical outcome measures and optimal study designs for future clinical trials. Improved consensus regarding these issues will provide a foundation for future basic science investigations, clinical trials and improved clinical evidence to guide patient treatment. Advances in treating FAI are dependent upon improved understanding of the disease pathophysiology and determining the clinical efficacy and economic value of distinct treatment interventions. The 2012 AAOS Femoroacetabular Impingement research symposium will emphasize a multidisciplinary approach and will focus on summarizing current knowledge, developing consensus and identifying research strategies for several key issues related to FAI. Focus topics will include: 1) The etiology, epidemiology and societal impact of hip OA; 2) The role of FAI in hip OA pathophysiology; 3) The basic science of FAI; 4) FAI disease screening, diagnostics, and disease staging; 5) The relative effectiveness and outcomes of different treatment modalities and optimal clinical science methodologies; and 6) Strategies for future basic and clinical investigations. PUBLIC HEALTH RELEVANCE: Osteoarthritis (OA) affects an estimated 30% of Americans over 60 years of age and is one of the leading causes of reduced quality of life and loss of function for orthopaedic patients. Lower extremity OA is particularly common and costly. Estimates show that by 2030 over 4.4 million hip and knee replacement procedures will be performed annually in the United States with the number of hip replacements increasing by 200%. Femoroacetabular impingement (FAI) has recently come to the forefront as a potential precursor to hip osteoarthritis. There is a major need for improved consensus regarding the definition, diagnosis, treatment and etiological role of FAI relative to hip OA.

描述（由申请人提供）：骨关节炎（OA）影响约30%的60岁以上的美国人，是骨科患者生活质量降低和功能丧失的主要原因之一。下肢骨关节炎特别常见且费用高昂。据估计，到2030年，美国每年将进行超过440万例髋关节和膝关节置换手术，髋关节置换术的数量将增加200%。需要创新策略来更有效地诊断、预防和治疗OA。未来的治疗创新将侧重于疾病的早期检测和治疗干预，以预防或阻止疾病进展并保护自然髋关节。在过去的十年里，在阐明髋关节骨关节炎的病理生理学方面取得了重大进展。最重要的是，股骨髋臼撞击（FAI）的深刻病因学作用已经成为最重要的问题。FAI的特征是股骨近端和髋臼的结构畸形，沿髋臼缘产生异常重复性基台沿着，导致过度载荷、髋臼缘软骨损伤和进行性关节退化。FAI患者存在于不同的年龄，疾病的不同阶段。由于患者人群的异质性和疾病特征的可变性，FAI的治疗包括各种肌肉骨骼医疗保健提供者，包括骨科医生（成人重建、儿科、运动和创伤）、风湿病学家、理疗师、物理治疗师和初级保健医生。尽管最近的兴趣和技术创新的外科治疗FAI，有一个主要的需要在这个新兴领域的基础和临床研究。此外，关于FAI在髋关节OA中的病因作用、FAI的自然史、FAI的病理生理学、最佳诊断和疾病分期模式、不同治疗技术的疗效以及最合适的临床结局指标和未来临床试验的最佳研究设计，仍存在重大争议。关于这些问题的更好的共识将为未来的基础科学研究、临床试验和改进的临床证据提供基础，以指导患者治疗。治疗FAI的进展取决于对疾病病理生理学的更好理解，以及确定不同治疗干预措施的临床疗效和经济价值。2012年AAOS股骨髋臼撞击研究研讨会将强调多学科方法，并将重点总结当前知识，建立共识，并确定与FAI相关的几个关键问题的研究策略。重点议题将包括：1）髋关节OA的病因学、流行病学和社会影响; 2）FAI在髋关节OA病理生理学中的作用; 3）FAI的基础科学; 4）FAI疾病筛查、诊断和疾病分期; 5）不同治疗方式和最佳临床科学方法的相对有效性和结局;以及6）未来基础和临床研究的策略。公共卫生相关性：骨关节炎（OA）影响估计30%的60岁以上的美国人，并且是骨科患者生活质量降低和功能丧失的主要原因之一。下肢骨关节炎特别常见且费用高昂。据估计，到2030年，美国每年将进行超过440万例髋关节和膝关节置换手术，髋关节置换术的数量将增加200%。股骨髋臼撞击（FAI）最近已经成为髋关节骨关节炎的潜在前兆。对于FAI相对于髋关节OA的定义、诊断、治疗和病因学作用，需要进一步达成共识。