FASEB SRC on "Helicases and Nucleic Acid Translocases: Structure, Mechanism, Fun

描述（由申请人提供）：本申请请求支持题为“解旋酶和核酸移位酶：结构，机制，功能和在人类疾病中的作用”的会议。本次会议由美国实验生物学学会联合会（FASEB）主办，将于2011年7月31日至8月5日在科罗拉多的汽船泉举行。近年来，解旋酶和其他核酸移位酶的研究激增，这是由于这些酶在RNA和DNA代谢的各个方面都发挥着核心作用。在过去的几年中，也已经清楚的是，许多解旋酶直接参与老化过程。最突出的是，DNA解旋酶的RecQ和FancJ家族在衰老中具有直接作用。人类RecQ蛋白的缺陷导致Werner和Rothmund-Thomson综合征的过早衰老和癌症易感性。FancJ突变与范可尼贫血的相似临床表现有关。最近才发现的RecQ和FancJ相关疾病之间的分子联系将是会议的主要议题。此外，影响染色质结构和功能的核酸易位酶通过其以基因组结构依赖性方式影响基因表达的能力在调节衰老相关过程中具有明显的重要性。解旋酶和移位酶的这些和其他关键作用使得越来越需要在研究结构、分子和细胞功能以及与本次会议重点有关的疾病和衰老过程的不同科学家群体之间交流信息。会议将涵盖解旋酶和易位酶的各个方面，从结构到人类疾病，所有这些都正在被深入研究。通过强调在适度规模的会议环境中进行特殊研究，FASEB会议为新老研究人员之间的信息，技术和观点交流提供了独特的机会。会议将包括九个主要的科学会议和三个海报会议，以及非正式讨论的空间。主要演讲者包括该领域的知名科学家和年轻科学家。会议的形式预计将提供背景资料，并使新的调查人员有机会提出他们的数据和想法，供公开讨论。 公共卫生相关性：在过去的几年里，人们已经清楚地看到，许多解旋酶和易位酶在衰老过程中发挥着重要作用。这次会议将有助于描绘解旋酶和移位酶与衰老和疾病状态之间的联系，通过促进研究这些重要酶的结构、分子和细胞功能的各个方面的不同科学家群体之间的生动信息交流。

DESCRIPTION (provided by applicant): This application requests support for the conference entitled "Helicases and Nucleic Acid Translocases: Structure, Mechanism, Function, and Roles in Human Disease". This conference is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 31 to August 5, 2011, in Steamboat Springs, Colorado. Research on helicases and other nucleic acid translocases has exploded in the recent years, due to the central role of these enzymes in essentially every aspect of RNA and DNA metabolism. Over the last years, it has also become clear that numerous helicases are directly involved in the aging process. Most prominently, the RecQ and FancJ families of DNA helicases have direct roles in aging. Defects in human RecQ proteins cause premature aging and cancer predisposition in Werner and Rothmund-Thomson syndromes. Mutations in FancJ are linked to similar clinical manifestations in Fanconi Anemia. The molecular connections between RecQ- and FancJ-related diseases, discovered only very recently, will be a major topic at the conference. In addition, nucleic translocases that affect chromatin structure and function have a clear importance in the regulation of aging-related processes through their ability to affect gene expression in a genome structure-dependent manner. These and other critical roles of helicases and translocases have created a growing need for exchange of information among the diverse group of scientists studying the structure, molecular and cellular functions, as well as diseases and the aging process associated with the focus of this meeting. The conference will cover all aspects of helicases and translocases, from structure to human disease, all of which are being intensely studied. By emphasizing exceptional research in a modestly sized conference setting, the FASEB conference provides unique opportunities for the exchange of information, technology and perspective among new and established investigators. The conference will encompass nine major scientific sessions and three poster sessions, as well as room for informal discussion. Speakers for major talks include established scientists in the field as well as younger scientists. The conference format is expected to provide background information and to give new investigators the opportunity to present their data and ideas for open discussion. PUBLIC HEALTH RELEVANCE: Over the last years, it has become clear that numerous helicases and translocases play important roles in the aging process. This meeting will help to delineate connections between helicases and translocases and aging and disease states by facilitating a vivid exchange of information among a diverse group of scientists studying all aspects of structure, molecular and cellular functions of these important enzymes.