PNI Mechanisms of Disease: From Pathophysiology to Prevention and Treatment

PNI 疾病机制：从病理生理学到预防和治疗

• 批准号: 8128212
• 负责人: Gayle Giboney Page
• 金额: $ 1.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-02 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128212
• 关键词: Accounting; Aging; Award; Basic Science; Behavior; Behavioral; Behavioral Medicine; Brain; Cancer Patient; Cell physiology; Chicago; Clinical; Competence; Complementary Medicine; Complementary and alternative medicine; Data; Development; Discipline; Disease; Disease susceptibility; Education; Educational workshop; Endocrine; Ensure; Exposure to; Faculty; Fatigue; Fostering; Functional disorder; Goals; Grant; Health Promotion; Health Psychology; Illinois; Immune; Immune system; Immunity; Immunology; Impaired cognition; Individual; Inflammatory; Institutes; Instruction; Integration Host Factors; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Life Style; Link; Lymphocyte; Malignant Neoplasms; Mental Depression; Mental Health; Mentors; Methodology; Mission; Molecular Biology; Morbidity - disease rate; National Cancer Institute; Neurosciences; Neurosecretory Systems; Oral; Outcome Measure; Pathologic Mutagenesis; Pathway interactions; Population; Predisposition; Prevention; Prevention Research; Process; Productivity; Professional Organizations; Psychological Factors; Psychology; Psychoneuroimmunology; Publications; Quality of life; Recommendation; Request for Proposals; Research; Research Personnel; Role; Science; Scientist; Societies; Staging; Stress; Techniques; Training; Training Programs; Translational Research; Travel; United States National Institutes of Health; Universities; Variant; Writing; abstracting; base; behavioral health; biobehavior; body-mind; career; clinically relevant; cost; cytokine; design; disorder prevention; improved; insight; interest; lectures; lifestyle factors; meetings; member; mortality; neuroimmunology; neuropsychiatry; next generation; novel; pathogen; posters; pre-doctoral; programs; psychologic; skills; success; symposium; theories; tumor progression

DESCRIPTION (provided by applicant): This R13 meeting proposal requests support to continue an annual training and mentoring program for 20 - 25 pre- and postdoctoral trainees at the 18th annual meeting of the PsychoNeuroImmunology Research Society (PNIRS), June 8-11, 2011, to be held in Chicago, Illinois. Opportunities for advanced, interdisciplinary training of junior scientists interested in the basic science aspects of behavioral and neuroimmune interactions and their translational relevance for disease prevention and treatment are often limited at the university level. Since 1999, the PNIRS meeting has received NIH support to provide formal didactic instruction and constructive career guidance for over 245 fellows. The primary goal is to create pedagogical opportunities and offer supportive mentoring at this formative stage in the trainee's career in order to enhance their research potential and trajectory for success. The PNIRS is the primary professional organization representing the many diverse scientific disciplines involved in these types of inquiry. The PNIRS has approximately 300 regular members, including approximately 40% early in their career. The PNIRS Training Committee oversees the Society's commitment to the mentoring program and ensures its quality. Selection of the Trainee Scholars, including five diversity trainees, is based upon an open competition, and is determined by research excellence and career promise. The impact of this program is evident by the productivity of previous awardees and their scientific successes. In addition to the exposure to a rapidly evolving science, plenary and keynote talks, and symposia offered by leading scientists, the trainees participate in an Educational Short Course, a Senior Faculty-Trainee Mentoring Colloquium, Junior Faculty and Trainee workshop, and roundtable discussions with NIH program staff. Trainee abstract submissions are also reviewed for potential inclusion in thematic oral sessions developed from competitive abstract submissions and the "Data Blitz" sessions that immediately precede each poster session. Finally, a trainee dinner is held to further nurture the establishment of enduring collaborative and scientific relationships. This training and mentoring program is congruent with the mission of the National Cancer Institute (NCI) and other NIH institutes to increase the number of young scientists investigating biobehavioral pathways linking lifestyle and psychological factors to the promotion of health and to deciphering the role of host factors in the pathophysiology of disease. Psychoneuroimmunology (PNI) related research has shown that psychological factors and life style can impact immune competence and influence disease susceptibility. PNI biobehavioral research findings are germane to cancer and help to account for variations in cancer morbidity and mortality as well as quality of life. PNI methodologies also offer unique assessment strategies and outcome measures for evaluating the efficacy of nontraditional and complementary medicine approaches. Based on an enriched understanding of brain-immune interactions, PNI has also provided novel insights into the potential contributions of the immune system to neuropsychiatric disorders. PUBLIC HEALTH RELEVANCE: This R13 meeting award will enable 20 - 25 of the most promising pre- and postdoctoral research scientists to participate in the upcoming 2011 PsychoNeuroImmunology Research Society meeting to be held June 8 - 11 in Chicago, IL. These Scholar Awardees will have the opportunity to disseminate their findings and participate in special training and mentoring activities that will improve their likelihood of having a successful career in interdisciplinary basic science and translational research germane to the mission of the National Institutes of Health.

说明（由申请人提供）：本 R13 会议提案请求支持在 2011 年 6 月 8 日至 11 日在伊利诺伊州芝加哥举行的心理神经免疫学研究协会 (PNIRS) 第 18 届年会上继续为 20 - 25 名博士前和博士后学员提供年度培训和指导计划。对行为和神经免疫相互作用的基础科学及其与疾病预防和治疗的转化相关性感兴趣的初级科学家的高级跨学科培训机会往往仅限于大学一级。自 1999 年以来，PNIRS 会议得到了 NIH 的支持，为超过 245 名研究员提供正式的教学指导和建设性的职业指导。主要目标是在受训者职业生涯的这个形成阶段创造教学机会并提供支持性指导，以增强他们的研究潜力和成功轨迹。 PNIRS 是代表此类调查所涉及的许多不同科学学科的主要专业组织。 PNIRS 拥有大约 300 名正式会员，其中大约 40% 处于职业生涯早期。 PNIRS 培训委员会负责监督协会对指导计划的承诺并确保其质量。实习学者（包括五名多元化实习生）的选拔是基于公开竞争，并由卓越的研究成果和职业前景决定。该计划的影响从先前获奖者的生产力及其科学成就中可见一斑。除了接触快速发展的科学、由顶尖科学家提供的全体会议和主题演讲以及研讨会之外，学员还参加教育短期课程、高级教师-实习生指导座谈会、初级教师和实习生研讨会以及与 NIH 项目工作人员的圆桌讨论。实习生提交的摘要也会经过审查，以确定是否可能包含在由竞争性摘要提交和紧接着每个海报会议之前的“数据闪电战”会议开发的主题口头会议中。最后，举行学员晚宴，以进一步促进建立持久的合作和科学关系。这项培训和指导计划与美国国家癌症研究所 (NCI) 和其他 NIH 机构的使命相一致，即增加年轻科学家的数量，研究将生活方式和心理因素与促进健康联系起来的生物行为途径，并破译宿主因素在疾病病理生理学中的作用。心理神经免疫学（PNI）相关研究表明，心理因素和生活方式可以影响免疫能力，影响疾病易感性。 PNI 生物行为研究结果与癌症密切相关，有助于解释癌症发病率和死亡率以及生活质量的变化。 PNI 方法还提供独特的评估策略和结果衡量标准，用于评估非传统和补充医学方法的功效。基于对大脑-免疫相互作用的丰富理解，PNI 还为免疫系统对神经精神疾病的潜在贡献提供了新的见解。 公共健康相关性：R13 会议奖将使 20 - 25 名最有前途的博士前和博士后研究科学家能够参加即将于 6 月 8 日至 11 日在伊利诺伊州芝加哥举行的 2011 年心理神经免疫学研究协会会议。这些学者获奖者将有机会传播他们的发现并参加特殊培训和指导活动，这将提高他们在与美国国立卫生研究院使命密切相关的跨学科基础科学和转化研究领域取得成功职业生涯的可能性。