Molecular, Structural & Clinical Aspects of Vitamin K-Dependent Proteins

分子、结构

• 批准号: 8199870
• 负责人: KATHLEEN Lucile BERKNER
• 金额: $ 2.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199870
• 关键词: Address; Area; Basic Science; Biochemical; Biochemistry; Biology; Blood Vessels; Blood coagulation; Cardiovascular Diseases; Cartilage; Cellular biology; Chairperson; Clinical; Cognitive Science; Collaborations; Communities; Degenerative polyarthritis; Development; Diabetes Mellitus; Dietary Factors; Discipline; Drug Kinetics; Endocrinology; Energy Metabolism; Ensure; Enzymatic Biochemistry; Future; Genetic; Genetic Polymorphism; Geriatrics; Goals; Health; Hemostatic function; Hormonal; International; Knowledge; Metabolic; Metabolism; Mission; Molecular; Nature; Nervous System Physiology; Oral; Osteocalcin; Physiological; Proteins; Public Health; Research; Research Personnel; Resistance; Role; Scientific Societies; Scientist; Structure-Activity Relationship; Therapeutic; Time; Tissues; Translational Research; Vascular calcification; Vitamin K; base; burden of illness; clinical application; dietary requirement; experience; gamma-glutamyl carboxylase; innovation; interdisciplinary approach; meetings; multidisciplinary; novel; nutrition; posters; prevent; programs; response; skeletal; skeletal tissue; symposium; vitamin K epoxide reductase

DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis. However, the field of VK now extends beyond this focus and is actively being studied across highly diverse disciplines by investigators new to the VK field. Scientific interactions have become increasingly challenging because VK biology is no longer represented by a single scientific society. The 2011 FASEB Summer Conference on "Molecular, Structural & Clinical Aspects of VK & VK-Dependent Proteins" is significant to the field because it is the only national and/or international conference dedicated to the study of VK biology. The overall objective of this conference is to provide a forum for the exchange of new knowledge about VK that spans from basic research to a wide variety of clinical applications. In recognition of this unique and highly disciplinary theme, our overarching conference goals are to: (1) Feature recognized multidisciplinary experts covering topics related to VK; (2) Discuss major advances in the field among young and experienced investigators, including those who are based in disciplines not traditionally associated with the VK community; and (3) Ensure a continued influx of new ideas and new investigators. To achieve this, we have created a program composed of many speakers who will be interacting with the VK community for the first time. We have also incorporated multiple opportunities for the interaction of graduate and post-graduate trainees and junior scientists with established investigators to promote a new cadre of investigators in the field of VK. The scientific problems to be discussed at the 2011 conference reflect this translational nature of VK biology: (1) Evolve the understanding of the VK-dependent carboxylase, and the VK epoxide reductase (VKOR); (2) Integrate the metabolic roles of newly discovered multiple VK-dependent proteins with important new findings regarding VK action in skeletal tissue, cartilage, and vascular tissues; (3) Evaluate the new developments that suggest emerging roles for VK and VK- dependent proteins in optimal functioning of the nervous system; and (4) Advance our current knowledge on VK metabolism used to formulate dietary requirements with recent findings in enzymology and pharmacokinetics. This conference is innovative because it will provide discussion on new linkages and roles of VK by drawing on the multi-disciplinary expertise of confirmed chairpersons and speakers in the fields of cell biology, biochemistry, cognitive psychology, and nutrition, and will facilitate new collaborations and areas of novel research. PUBLIC HEALTH RELEVANCE: The proposal to support the 2011 FASEB Summer Vitamin K (VK) conference is relevant to public health because it will promote interaction and future translational research collaborations to further our understanding of the emerging roles of VK in the promotion of skeletal health, and preventing vascular calcification and other health-related responses that may be associated with inadequate VK status. Thus, the proposed research is relevant to the NIH's mission to develop the identification of modifiable dietary factors that will help reduce the burden of diseases, such as cardiovascular disease, diabetes, and osteoarthritis.

描述（由申请方提供）：维生素K（VK）因其止血作用而被发现，历史上的要求是基于正常凝血所需的量。在过去，VK领域的凝聚力主要是通过对止血的关注来维持的。然而，VK领域现在已经超出了这一重点，并且正在由VK领域的新研究人员积极研究高度多样化的学科。科学互动变得越来越具有挑战性，因为VK生物学不再由一个单一的科学社会代表。2011年FASEB夏季会议“VK和VK依赖蛋白质的分子，结构和临床方面”对该领域具有重要意义，因为它是唯一致力于VK生物学研究的国家和/或国际会议。本次会议的总体目标是提供一个论坛，交流有关VK的新知识，从基础研究到各种临床应用。在认识到这一独特的和高度学科化的主题，我们的总体会议目标是：（1）功能公认的多学科专家，涵盖与VK相关的主题;（2）讨论在年轻和经验丰富的研究人员，包括那些谁是基于传统上不与VK社区相关的学科领域的重大进展;和（3）确保新的想法和新的研究人员的持续涌入。为了实现这一目标，我们创建了一个由许多演讲者组成的计划，他们将首次与VK社区进行互动。我们还为毕业生和研究生学员以及初级科学家与既定调查人员的互动提供了多种机会，以促进VK领域新的调查人员队伍。在2011年会议上讨论的科学问题反映了VK生物学的这种转化性质：（1）发展对VK依赖性羧化酶和VK环氧化物还原酶（VKOR）的理解;（2）将新发现的多种VK依赖性蛋白的代谢作用与关于骨骼组织、软骨和血管组织中VK作用的重要新发现相结合;（3）评估表明VK和VK依赖性蛋白在神经系统的最佳功能中的新兴作用的新发展;以及（4）利用酶学和药代动力学的最新发现推进我们目前关于用于制定膳食需求的VK代谢的知识。本次会议是创新的，因为它将通过借鉴细胞生物学，生物化学，认知心理学和营养学领域确认的主席和发言人的多学科专业知识，提供关于VK新联系和作用的讨论，并将促进新的合作和新的研究领域。 公共卫生关系：支持2011年FASEB夏季维生素K（VK）会议的提案与公共卫生有关，因为它将促进互动和未来的转化研究合作，以进一步了解VK在促进骨骼健康，预防血管钙化和其他可能与VK状态不足相关的健康相关反应中的新兴作用。因此，拟议中的研究与NIH的使命相关，即开发可改变的饮食因素的识别，这将有助于减少疾病的负担，如心血管疾病，糖尿病和骨关节炎。