Molecular, Structural & Clinical Aspects of Vitamin K-Dependent Proteins

分子、结构

• 批准号: 8199870
• 负责人: KATHLEEN Lucile BERKNER
• 金额: $ 2.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199870
• 关键词: Address; Area; Basic Science; Biochemical; Biochemistry; Biology; Blood Vessels; Blood coagulation; Cardiovascular Diseases; Cartilage; Cellular biology; Chairperson; Clinical; Cognitive Science; Collaborations; Communities; Degenerative polyarthritis; Development; Diabetes Mellitus; Dietary Factors; Discipline; Drug Kinetics; Endocrinology; Energy Metabolism; Ensure; Enzymatic Biochemistry; Future; Genetic; Genetic Polymorphism; Geriatrics; Goals; Health; Hemostatic function; Hormonal; International; Knowledge; Metabolic; Metabolism; Mission; Molecular; Nature; Nervous System Physiology; Oral; Osteocalcin; Physiological; Proteins; Public Health; Research; Research Personnel; Resistance; Role; Scientific Societies; Scientist; Structure-Activity Relationship; Therapeutic; Time; Tissues; Translational Research; Vascular calcification; Vitamin K; base; burden of illness; clinical application; dietary requirement; experience; gamma-glutamyl carboxylase; innovation; interdisciplinary approach; meetings; multidisciplinary; novel; nutrition; posters; prevent; programs; response; skeletal; skeletal tissue; symposium; vitamin K epoxide reductase

DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis. However, the field of VK now extends beyond this focus and is actively being studied across highly diverse disciplines by investigators new to the VK field. Scientific interactions have become increasingly challenging because VK biology is no longer represented by a single scientific society. The 2011 FASEB Summer Conference on "Molecular, Structural & Clinical Aspects of VK & VK-Dependent Proteins" is significant to the field because it is the only national and/or international conference dedicated to the study of VK biology. The overall objective of this conference is to provide a forum for the exchange of new knowledge about VK that spans from basic research to a wide variety of clinical applications. In recognition of this unique and highly disciplinary theme, our overarching conference goals are to: (1) Feature recognized multidisciplinary experts covering topics related to VK; (2) Discuss major advances in the field among young and experienced investigators, including those who are based in disciplines not traditionally associated with the VK community; and (3) Ensure a continued influx of new ideas and new investigators. To achieve this, we have created a program composed of many speakers who will be interacting with the VK community for the first time. We have also incorporated multiple opportunities for the interaction of graduate and post-graduate trainees and junior scientists with established investigators to promote a new cadre of investigators in the field of VK. The scientific problems to be discussed at the 2011 conference reflect this translational nature of VK biology: (1) Evolve the understanding of the VK-dependent carboxylase, and the VK epoxide reductase (VKOR); (2) Integrate the metabolic roles of newly discovered multiple VK-dependent proteins with important new findings regarding VK action in skeletal tissue, cartilage, and vascular tissues; (3) Evaluate the new developments that suggest emerging roles for VK and VK- dependent proteins in optimal functioning of the nervous system; and (4) Advance our current knowledge on VK metabolism used to formulate dietary requirements with recent findings in enzymology and pharmacokinetics. This conference is innovative because it will provide discussion on new linkages and roles of VK by drawing on the multi-disciplinary expertise of confirmed chairpersons and speakers in the fields of cell biology, biochemistry, cognitive psychology, and nutrition, and will facilitate new collaborations and areas of novel research. PUBLIC HEALTH RELEVANCE: The proposal to support the 2011 FASEB Summer Vitamin K (VK) conference is relevant to public health because it will promote interaction and future translational research collaborations to further our understanding of the emerging roles of VK in the promotion of skeletal health, and preventing vascular calcification and other health-related responses that may be associated with inadequate VK status. Thus, the proposed research is relevant to the NIH's mission to develop the identification of modifiable dietary factors that will help reduce the burden of diseases, such as cardiovascular disease, diabetes, and osteoarthritis.

描述（由申请人提供）：维生素K（VK）是因为其在止血中的作用而发现的，并且在历史上是基于正常血液凝结所需的数量。过去，VK场的凝聚力在很大程度上是通过对止血的关注来维持的。但是，VK的领域现在扩展到了这一重点，并且正在由VK Field的调查人员积极研究高度多样化的学科。科学互动变得越来越具有挑战性，因为VK生物学不再由一个科学社会代表。 2011年FASEB夏季会议“ VK＆VK依赖性蛋白质的分子，结构和临床方面”对该领域很重要，因为它是唯一致力于研究VK生物学研究的全国和/或国际会议。这次会议的总体目的是提供一个论坛，以交换有关VK的新知识，该知识从基础研究到各种临床应用。为了表彰这个独特且高学科的主题，我们的总体会议目标是：（1）功能公认的多学科专家，涵盖与VK相关的主题； （2）讨论年轻和经验丰富的调查人员中该领域的重大进展，包括基于传统上与VK社区相关的学科的研究人员； （3）确保持续涌入新的想法和新调查人员。为了实现这一目标，我们创建了一个由许多演讲者组成的计划，这些计划将首次与VK社区互动。我们还为研究生和研究生学员以及初级科学家与已建立的研究人员的互动融合了多个机会，以促进VK领域的新调查人员干部。在2011年会议上要讨论的科学问题反映了VK生物学的这种翻译性质：（1）进化对VK依赖性羧化酶的理解，而VK Epoxide还原酶（VKOR）； （2）整合了新发现的多种VK依赖性蛋白的代谢作用，以及有关骨骼组织，软骨和血管组织中VK作用的重要新发现； （3）评估提示VK和VK依赖性蛋白在神经系统最佳功能中的新发展的新发展； （4）促进我们目前对VK代谢的知识，用于制定饮食需求，并在酶学和药代动力学方面的最新发现。这次会议具有创新性，因为它将通过借鉴细胞生物学，生物化学，认知心理学和营养领域的确认主席和演讲者的多学科专业知识来提供有关VK的新联系和角色的讨论，并将促进新研究的新合作和领域。 公共卫生相关性：支持2011 FaseB夏季维生素K（VK）会议的提案与公共卫生有关，因为它将促进互动和未来的翻译研究合作，以进一步了解VK在促进骨骼健康中的新兴作用，并防止血管钙化和其他与健康相关的反应以及可能与Inadequate VK状态相关的健康反应。因此，拟议的研究与NIH的使命是发展可修改的饮食因素的使命，这些因素将有助于减轻疾病的负担，例如心血管疾病，糖尿病和骨关节炎。