The 6th International Leukocyte Signal Transduction Workshop

描述(申请人提供)：适当的免疫反应依赖于不同白细胞和其他细胞类型及其可溶性产物之间的复杂相互作用，以及许多受体之间的广泛串扰，这些受体传递激活信号，导致诱导细胞特异性基因程序、分化、增殖和获得效应器功能。放松免疫反应可能会导致有害的结果，自身免疫性疾病的发展就是一个很好的例子。导致炎症和自身免疫发展的异常机制在很大程度上是通过对小鼠的遗传操作来阐明的，这导致了对潜在信号机制的重大洞察。因此，信号通路在特定步骤上的基因改变可以预防或诱导自身免疫和其他免疫性疾病的发展。然而，小型科学会议能够进行密集的互动和富有成果的讨论，同时将致力于研究白细胞信号通路的基本方面和这些途径的临床意义(包括相关疾病模型)的科学家聚集在一起，这样的会议还很少。请求提供资金以支持将于6/5-10/11在希腊克里特岛举行的题为“第六届国际白细胞信号转导研讨会”的国际会议。这是自2000年以来举行的一系列类似会议中的第六次。即将到来的会议的计划预计将有80-90名与会者，他们将汇聚致力于以下工作的科学家：i)白细胞信号通路的基本方面；ii)这些通路的动物疾病模型和临床意义；以及iii)相关的尖端技术。特邀教员由~26名国际知名科学家组成，他们是相关研究领域的公认专家。处于职业生涯早期形成阶段的科学家将优先参与和陈述。研讨会的具体目标是：1.通过重点关注自上一次(第五次)研讨会以来产生的重大新发现和发现，扩展并继续举办之前的五个高生产率的白细胞信号转导研讨会。2.召集国际知名科学家，他们是白细胞信号转导和白细胞信号通路对炎症、自身免疫和传染病等疾病影响的专家，以介绍和讨论最新的相关研究。3.让处于职业生涯早期阶段的科学家，即博士后研究员和研究生，特别是代表少数群体或来自发展中国家的科学家，有机会介绍自己的工作，并从与领先科学家的密切、一对一的互动中受益，从而提供教育经验和致力于科学研究事业的动力。主办方预计，这次研讨会将提供有关所涵盖主题的最新信息，并将促进致力于白细胞信号基本方面的科学家与研究动物或人类炎症和自身免疫疾病的科学家之间的想法分享和合作。 与公共卫生有关：要求为题为“第六届国际白细胞信号转导讲习班”的会议提供财政支持。这次研讨会是2000年开始的一系列卓有成效的会议中的第六次，将于2011年6月5日至10日在希腊克里特岛举行，将有来自不同国家的约80至90名与会者参加，其中包括约26名国际知名演讲者的杰出教职人员，他们都是各自研究领域的公认领导者。会议的中心焦点将是免疫系统中不同类型的细胞通过哪些生化和分子机制获得针对入侵微生物的有效免疫防御反应的能力，以及这些途径中的异常如何导致自身免疫和炎症等免疫系统疾病。所请求的支助将主要用于支付注册费用和生活费，优先考虑年轻科学家和代表人数不足群体的个人。

DESCRIPTION (provided by applicant): A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an extensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A deregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled "The 6th International Leukocyte Signal Transduction Workshop" to be held in Crete, Greece, on 6/5-10/11. This is the 6th in a series of similar meetings, which were held since 2000. The program for the upcoming meeting, with ~80-90 anticipated participants, will bring together scientists working on: i) fundamental aspects of leukocyte signaling pathways; ii) animal disease models and clinical implications of these pathways; and iii) relevant cutting edge technologies. The invited faculty consists of ~26 internationally known scientists who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. The Specific Aims of the Workshop are: 1. Extend and continue five previous, highly productive Leukocyte Signal Transduction Workshops, by focusing on major new discoveries and findings generated since the previous (5th) Workshop. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their career, i.e., postdoctoral research fellows and graduate students, particularly those representing minority groups or coming from developing countries, an opportunity to present their own work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a scientific research career. The Organizers anticipate that this Workshop will provide most up-to-date information on the covered topics, and will stimulate sharing of ideas and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal or human inflammatory and autoimmune diseases. PUBLIC HEALTH RELEVANCE: Financial support is requested for a conference entitled "The 6th International Leukocyte Signal Transduction Workshop". This Workshop, the 6th in a series of highly productive meetings initiated in 2000, will be held on June 5-10, 2011 in Crete, Greece, and will be attended by ~80-90 participants from different countries, including a distinguished faculty of ~26 internationally known speakers, who are all recognized leaders in their respective areas of research. The central focus of the meeting will be the biochemical and molecular mechanisms through which different cell types in the immune system acquire the ability to mount effective immune defense responses against invading microbes, and how aberrations in these pathways can lead to immune system diseases such as autoimmunity and inflammation. The requested support will mostly be used to defray the costs of meeting registration and subsistence costs, with high priority being given to young scientists and individuals from underrepresented groups.