The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica

第四届国际白细胞信号转导研讨会：临床意义

• 批准号: 7278001
• 负责人: AMNON ALTMAN
• 金额: $ 0.5万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278001
• 关键词: Animal Disease Models; Animal Model; Area; Autoimmune Diseases; Autoimmunity; Biochemical; Cells; Clinical; Collaborations; Commit; Communicable Diseases; Complex; Development; Disease; Disease model; Educational workshop; Faculty; Funding; Genes; Greece; Human; Immune System Diseases; Immune response; Inflammation; Inflammatory; International; Lead; Leukocytes; Motivation; Mus; Mutation; Participant; Pathway interactions; Range; Research; Scientist; Series; Signal Pathway; Signal Transduction; Staging; Students; Technology; Time; Work; career; cell type; clinical application; clinically relevant; experience; genetic manipulation; insight; member; prevent; professor; programs; receptor; symposium

A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an intensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled ?The 4th International Leukocyte Signal Transduction Workshop: Clinical Implications of Signaling Pathways? to be held in Rhodes, Greece, between 6/3-8/07. This is the 4th in a series of similar meetings, which were held since 2000. Previous meetings focused exclusively on basic aspects of signal transduction by leukocyte receptors. The upcoming meeting, with ~120 anticipated participants, will represent a significant departure from this focus. The Organizing Committee has drafted this time a program, which brings together scientists working on fundamental aspects of leukocyte signaling and those studying relevant animal disease models and clinical implications of these signaling pathways. In addition, several invited talks will present and discuss relevant cutting edge technologies. The invited faculty consists of 23 internationally known scientists (in addition to the Organizing Committee) who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. Together, the scientists participating in this Workshop cover different areas of research, which encompass a comprehensive range, from the subcellular, biochemical level of analysis, through whole cell and animal models, and up to clinical applications. The Specific Aims of the Workshop are: 1. Extend and continue three previous, highly productive Leukocyte Signal Transduction Workshops. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their formative career, i.e., junior faculty members (assistant professors), postdoctoral research fellows and graduate students an opportunity to present and discuss their own ongoing work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a clinically relevant scientific research career. The Organizers anticipate that this Workshop will promote sharing of ideas, close interactions and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal model (or even human) inflammatory and autoimmune diseases.

适当的免疫反应取决于不同白细胞和其他细胞之间复杂的相互作用 类型及其可溶性产物，以及许多受体之间的强烈串扰， 激活信号，导致诱导细胞特异性基因程序、分化、增殖， 获得效应器功能。免疫反应失调会导致有害的结果， 自身免疫性疾病就是一个很好的例子。异常机制导致 炎症和自身免疫的发展在很大程度上已经被遗传学阐明， 操纵小鼠，这导致了对潜在信号机制的重要见解。因此，在本发明中， 在确定的步骤中，信号通路的遗传改变可以预防或诱导 自身免疫和其他免疫性疾病。然而，小型的科学会议， 密集的互动和富有成效的讨论，同时，汇集了科学家， 白细胞信号通路的基本方面和这些通路的临床意义 （包括相关疾病模型）相差甚远。 要求提供资金，以支助一次题为“？第四届国际白细胞信号 转导研讨会：信号通路的临床意义？在希腊的罗兹举行， 在07年6月3日到8日之间。这是自2000年以来举行的一系列类似会议中的第四次。先前 会议专门讨论了白细胞受体信号转导的基本方面。的 即将举行的会议预计将有约120名与会者，这将大大偏离这一重点。 组委会这次起草了一个计划，汇集了科学家， 白细胞信号传导的基本方面和研究相关动物疾病模型和临床的那些方面 这些信号通路的影响。此外，几个受邀会谈将介绍和讨论有关 尖端技术。受邀教师由23名国际知名科学家组成（除 组委会），他们是相关研究领域的公认专家。科学家在早期， 他们职业生涯的形成阶段将优先考虑参与和展示。统称 参加这次研讨会的科学家涵盖不同的研究领域，其中包括 范围全面，从亚细胞、生化水平分析，一直到全细胞和动物 模型，以及临床应用。 讲习班的具体目标是： 1.扩展并继续之前三个高效率的白细胞信号转导研讨会。 2.汇集了国际知名的科学家，他们是白细胞信号转导方面的专家， 白细胞信号传导途径的疾病影响，例如，炎症、自身免疫和 传染病，以介绍和讨论最新的相关研究。 3.给科学家在他们的职业生涯形成的早期阶段，即，初级教员（助理 教授），博士后研究员和研究生有机会提出和讨论 他们自己正在进行的工作，并受益于密切，一对一的互动与领先的科学家，从而 提供教育经验和动机，致力于临床相关的 科学研究生涯。 主办单位预期，这次研讨会将促进交流意见，密切互动， 研究白细胞信号传导基本方面的科学家和研究 动物模型（甚至人类）炎症和自身免疫性疾病。