The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica

第四届国际白细胞信号转导研讨会：临床意义

• 批准号: 7278001
• 负责人: AMNON ALTMAN
• 金额: $ 0.5万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278001
• 关键词: Animal Disease Models; Animal Model; Area; Autoimmune Diseases; Autoimmunity; Biochemical; Cells; Clinical; Collaborations; Commit; Communicable Diseases; Complex; Development; Disease; Disease model; Educational workshop; Faculty; Funding; Genes; Greece; Human; Immune System Diseases; Immune response; Inflammation; Inflammatory; International; Lead; Leukocytes; Motivation; Mus; Mutation; Participant; Pathway interactions; Range; Research; Scientist; Series; Signal Pathway; Signal Transduction; Staging; Students; Technology; Time; Work; career; cell type; clinical application; clinically relevant; experience; genetic manipulation; insight; member; prevent; professor; programs; receptor; symposium

A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an intensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled ?The 4th International Leukocyte Signal Transduction Workshop: Clinical Implications of Signaling Pathways? to be held in Rhodes, Greece, between 6/3-8/07. This is the 4th in a series of similar meetings, which were held since 2000. Previous meetings focused exclusively on basic aspects of signal transduction by leukocyte receptors. The upcoming meeting, with ~120 anticipated participants, will represent a significant departure from this focus. The Organizing Committee has drafted this time a program, which brings together scientists working on fundamental aspects of leukocyte signaling and those studying relevant animal disease models and clinical implications of these signaling pathways. In addition, several invited talks will present and discuss relevant cutting edge technologies. The invited faculty consists of 23 internationally known scientists (in addition to the Organizing Committee) who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. Together, the scientists participating in this Workshop cover different areas of research, which encompass a comprehensive range, from the subcellular, biochemical level of analysis, through whole cell and animal models, and up to clinical applications. The Specific Aims of the Workshop are: 1. Extend and continue three previous, highly productive Leukocyte Signal Transduction Workshops. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their formative career, i.e., junior faculty members (assistant professors), postdoctoral research fellows and graduate students an opportunity to present and discuss their own ongoing work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a clinically relevant scientific research career. The Organizers anticipate that this Workshop will promote sharing of ideas, close interactions and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal model (or even human) inflammatory and autoimmune diseases.

适当的免疫反应取决于不同白细胞与其他细胞之间的复杂相互作用 类型及其可溶性产品，以及许多受体的密集串扰 激活信号导致诱导细胞特异性基因程序，分化，增殖和 效应功能的获取。免疫反应失调可能导致有害结果， 自身免疫性疾病的发展是一个很好的例子。导致的异常机制 遗传已经阐明了炎症和自身免疫性的发展 操纵小鼠，这导致了对基本信号机制的重大见解。因此， 在定义步骤处的信号通路的遗传改变可以防止或诱导 自身免疫性和其他免疫疾病。然而，允许的小型科学会议 密集的互动和富有成果的讨论，同时，将科学家聚集在一起 白细胞信号通路的基本方面以及这些途径的临床意义 （包括相关疾病模型）之间的距离很少。 要求资金支持题为“国际会议？第四个国际白细胞信号” 转导研讨会：信号通路的临床意义？在希腊的罗得岛举行 在6/3-8/07之间。这是自2000年以来举行的一系列类似会议中的第四名。 会议仅集中在白细胞受体信号转导的基本方面。这 即将举行的约120名参与者的会议将与这一重点有很大的不同。 组织委员会这次起草了一个计划，该计划汇集了从事的科学家 白细胞信号传导和研究相关动物疾病模型和临床的基本方面 这些信号通路的含义。此外，将介绍并讨论几次邀请的演讲 最先进的技术。受邀教师由23位国际知名科学家组成（除了 组织委员会）是相关研究领域的公认专家。早期的科学家 他们职业生涯的形成阶段将在参与和演讲中优先。在一起， 参加该研讨会的科学家涵盖了不同的研究领域，其中包括 从亚细胞，生化分析水平到全细胞和动物的全面范围 模型，以及临床应用。 研讨会的具体目的是： 1。扩展并继续三个以前的高生产性白细胞信号转导研讨会。 2。将国际知名的科学家汇集在一起​​，他们是白细胞信号转导专家 白细胞信号传导途径的疾病意义，例如炎症，自身免疫性和 传染病，以介绍和讨论最新的相关研究。 3。在成立职业的早期阶段，即初级教师（助理） 教授），博士后研究研究员和研究生有机会介绍和讨论 他们自己正在进行的工作，并受益于与领先科学家的亲密，一对一的互动 提供教育经验和动力，以致力于临床相关 科学研究职业。 组织者预计该研讨会将促进共享思想，紧密互动和 从事白细胞信号基本方面的科学家与学习的人之间的合作 动物模型（甚至是人类）炎症和自身免疫性疾病。