7th International Leukocyte Signal Transduction Conference

第七届国际白细胞信号转导会议

• 批准号: 8594061
• 负责人: AMNON ALTMAN
• 金额: $ 0.3万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8594061
• 关键词: Address; Animal Disease Models; Animal Model; Animals; Area; Autoimmune Diseases; Autoimmunity; Biochemical; Biomedical Research; Cell model; Cells; Clinical; Collaborations; Commit; Communicable Diseases; Complex; Country; Developing Countries; Development; Disease; Disease model; Faculty; Financial Support; Funding; Genes; Grant; Greece; Hematologic Neoplasms; Human; Immune; Immune System Diseases; Immune response; Immune system; Individual; Inflammation; Inflammatory; International; Invaded; Lead; Leukocytes; Microbe; Minority Groups; Molecular; Motivation; Mus; Mutation; National Institute of Allergy and Infectious Disease; Participant; Pathway interactions; Research; Scientist; Series; Signal Pathway; Signal Transduction; Staging; Technology; Time; Work; career; cell type; clinical application; cost; defense response; experience; genetic manipulation; graduate student; insight; meetings; member; new technology; prevent; programs; public health relevance; receptor; symposium

DESCRIPTION (provided by applicant): A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an extensive crosstalk among many receptors, which transduce activating or inhibitory signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisitio of effector functions. A deregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. However, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support The 7th International Leukocyte Signal Transduction Conference to be held in Kos, Greece, on September 8-13, 2013. This is the latest in a series of similar meetings initiated in 2000. The meeting, with ~80 anticipated participants, will bring together scientists working on fundamental aspects of leukocyte signaling pathways, related animal disease models, and clinical implications of these pathways, who is cutting edge technologies to address fundamental immunological problems. The invited faculty consists of ~24 internationally known scientists who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation an presentation. The Specific Aims of the Conference are to: 1. Extend and continue six previous, highly productive Leukocyte Signal Transduction Conferences, by focusing on major new discoveries and findings generated since the previous (6th) Conference held in 2011. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their career, i.e., postdoctoral research fellows and graduate students, particularly those representing minority groups or coming from developing countries, an opportunity to present their own work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a biomedical research career. This conference will provide most up-to-date information on the covered topics, and will stimulate sharing of ideas and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal or human inflammatory and autoimmune diseases and hematopoietic cancers.

描述（由申请人提供）：适当的免疫反应取决于不同白细胞和其他细胞类型及其可溶性产物之间的复杂相互作用，以及许多受体之间的广泛串扰，这些受体转导激活或抑制信号，导致细胞特异性基因程序的诱导、分化、增殖和效应功能的获得。不受控制的免疫反应会导致有害的结果，自身免疫性疾病的发展就是一个典型的例子。通过对小鼠的遗传操作，在很大程度上阐明了导致炎症和自身免疫发展的异常机制，从而对潜在的信号传导机制有了重要的了解。因此，信号通路在特定步骤上的遗传改变可以预防或诱导自身免疫和其他免疫疾病的发展。然而，能够进行密集互动和富有成果的讨论，同时将研究白细胞信号传导途径基本方面和这些途径（包括相关疾病模型）的临床意义的科学家聚集在一起的小型科学会议却寥寥无几。第七届国际白细胞信号转导会议将于2013年9月8日至13日在希腊科斯举行。这是2000年发起的一系列类似会议中最新的一次。这次会议预计将有大约80名与会者，将汇集研究白细胞信号通路基础方面、相关动物疾病模型和这些通路临床意义的科学家，他们是解决基本免疫学问题的前沿技术。特邀教师由约24名国际知名科学家组成，他们是相关研究领域公认的专家。处于职业生涯早期形成阶段的科学家将优先参加演讲。会议的具体目标是：1。通过关注自2011年举行的上一届（第6届）会议以来产生的重大新发现和发现，延续和继续之前的六届高成效的白细胞信号转导会议。2. 汇集国际知名科学家，他们是白细胞信号转导方面的专家，以及白细胞信号转导途径对炎症、自身免疫和传染病等疾病的影响，以介绍和讨论最新的相关研究。3. 给处于职业生涯早期阶段的科学家，即博士后研究员和研究生，特别是那些代表少数群体或来自发展中国家的科学家，一个展示自己工作的机会，并从与顶尖科学家的密切、一对一的互动中受益，从而提供一种教育经验和致力于生物医学研究事业的动力。本次会议将提供所涵盖主题的最新信息，并将促进研究白细胞信号基本方面的科学家与研究动物或人类炎症和自身免疫性疾病以及造血癌症的科学家之间的思想分享和合作。