2011 Tissue Repair and Regeneration Gordon Conference

描述（由申请人提供）：2011年戈登组织修复和再生研究会议（TRR-GRC）将于6月5日至10日在新罕布什尔州新伦敦的科尔比索耶学院举行。在这次会议的同时，戈登凯南研究生研究研讨会（GRS）将于6月4日至5日在同一地点举行。后一次会前会议旨在为研究生和博士后提供一个平台，以展示与组织修复/再生相关的工作，以便他们更充分地融入随后的TRR-GRC。这将是完整TRR-GRC的第十次迭代，也是第一次包括GRS预会议。这两个会议都涉及细胞/发育生物学和医学/组织工程的交叉点-身体的不同组织如何感知和响应组织损伤。这些主题是一个主要的公共卫生/临床问题，因为创伤或手术后伤口愈合不充分，以及涉及组织修复反应失调的疾病，如纤维化和癌症，每年影响美国数百万人。计划举办九次科学会议，涵盖组织修复和再生的基础和转化科学：1）危险信号，2）屏障修复和再生，3）组织工程，4）器官修复和再生，5）癌症作为一种失调的伤口愈合疾病，6）整个动物王国的再生模式，7）炎症，8）干细胞和再生医学，和9）基质和纤维化。在所有会议上，我们邀请了最近发表了广泛关注的高调故事的演讲者。会议2-4，6-7和9是本次会议的传统，而关于危险信号，癌症和伤口愈合以及干细胞/再生医学的会议旨在突出该领域的新兴新方向，来自任何学科的与会者都将受益于接触。事实上，TRR-GRC的独特之处在于，它传统上寻求非常多样化的科学家群体，从基础细胞生物学家/生物工程师到临床医生，用各种实验方法和模型来解决组织修复和再生的问题。让这些群体相互接触，并促进由此产生的讨论和合作，是TRR-GRC的一个主要长期目标。我们不同的发言者将强调未发表的结果，并鼓励他们的演讲，使与会者从他们的直接学科以外访问。初级科学家（学生和博士后）的参与将大大促进GRS会前会议，事实上，许多TRR-GRC邀请的演讲者和讨论领导者都是积极参与令人兴奋的新方向的初级研究人员。此外，还将辅之以对该领域具有全面历史观点的知名高级调查员。将鼓励和积极寻求代表性不足的少数民族的参与，并通过现有的TRR-GRC方案提供奖学金补贴他们的参与。慷慨的NIH支持将大大提高计划的质量和计划计划中的计划所促进的合作机会。 公共卫生相关性：该提案要求资金支持一个主题为组织修复和再生的科学会议。这些受试者是主要的公共卫生问题，因为创伤性损伤是美国年轻人死亡的主要原因，并且由于各种生理因素（年龄、感染、纤维化）或疾病状态（糖尿病、血管疾病、癌症）导致的愈合/修复不足是主要的临床关注和公共卫生负担。会议背后的理念是，对修复/再生基础科学的透彻理解可以转化为组织修复和再生的有效疗法。

DESCRIPTION (provided by applicant): The 2011 Gordon Research Conference on Tissue Repair and Regeneration (TRR-GRC) will be held from June 5-10 at Colby Sawyer College, New London, New Hampshire. In conjunction with this meeting, a Gordon-Kenan Graduate Research Symposium (GRS) will be held June 4-5 at the same site. This latter pre- meeting is designed to provide a platform for graduate students and post docs to present work relevant to tissue repair/regeneration so that they become more fully integrated into the TRR-GRC that follows. This will be the tenth iteration of the full TRR-GRC and the first that includes a GRS pre-meeting. Both conferences address topics that sit at the crossroads of cell/developmental biology and medicine/tissue engineering- how the body's different tissues sense and respond to tissue damage. These topics are a major public health/clinical concern as inadequate wound healing following trauma or surgery and diseases that involve misregulated tissue repair responses, such as fibrosis and cancer, affect millions in the US per year. Nine scientific sessions are planned which span the basic and translational science of tissue repair and regeneration: 1) Danger Signaling, 2) Barrier repair and regeneration, 3) Tissue Engineering, 4) Organ repair and regeneration, 5) Cancer as a disease of misregulated wound healing, 6) Regenerating pattern throughout the animal kingdom, 7) Inflammation, 8) Stem Cells and Regenerative Medicine, and 9) Matrix and Fibrosis. In all sessions we have invited speakers who have recently published high profile stories of broad interest. Sessions 2-4, 6-7, and 9 are traditional for this meeting whereas the sessions on danger signaling, cancer and wound healing, and stem Cells/regenerative medicine are meant to highlight emerging new directions in the field to which attendees from any discipline would benefit from exposure. Indeed, this TRR-GRC is unique in that it has traditionally sought a very diverse group of scientists, from basic cell biologists/bioengineers to clinicians, attacking the problems of tissue repair and regeneration with a variety of experimental approaches and models. Exposing these groups to each other and fostering the discussions and collaborations that result from this exposure, is a major longstanding goal of this TRR-GRC. Our diverse speakers will emphasize unpublished results and be encouraged to make their presentations accessible to attendees from outside their immediate disciplines. Participation by junior scientists (students and postdocs) will be greatly facilitated by the GRS pre-meeting and indeed many of the TRR-GRC invited speakers and discussion leaders are junior investigators actively taking the field in exciting new directions. These will be complemented with eminent senior investigators who have a comprehensive and historical view of the field. Participation by underrepresented minorities will be encouraged and actively sought and scholarships subsidizing their involvement will be offered through existing TRR-GRC programs. Generous NIH support will substantially enhance the quality of the program and collaborative opportunities fostered by the planned program. PUBLIC HEALTH RELEVANCE: This proposal requests funds to support a scientific meeting whose topic is tissue repair and regeneration. These subjects are a major public health concern as traumatic injury is a leading cause of death for young Americans and inadequate healing/repair due to a variety of physiological factors (age, infection, fibrosis) or disease states (diabetes, vascular disease, cancer) is a major clinical preoccupation and public health burden. The philosophy behind the meeting is that a thorough understanding of the basic science of repair/regeneration can be translated into effective therapies for tissue repair and regeneration.