Satellite Symposium on Obesity and Endocrine Disruptors

肥胖与内分泌干扰物卫星研讨会

• 批准号: 8129105
• 负责人: Nira Ben-Jonathan
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129105
• 关键词: Accounting; Adult; Age; Area; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cessation of life; Chemical Exposure; Chemicals; Child; Child health care; Congresses; Cultured Cells; Developed Countries; Development; Diabetes Mellitus; Digestive System Disorders; Disease; Dose; Elderly; Endocrine Disruptors; Endocrinology; Environment; Environmental Health; Environmental Risk Factor; Epidemic; Etiology; Europe; European; Exercise; Exposure to; Gene Mutation; Hormonal; Human; Human Development; In Vitro; Institutes; International; Kidney Diseases; Laboratory Animals; Life; Link; Low Birth Weight Infant; Meleagris gallopavo; Metabolic syndrome; Molecular; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obesity associated disease; Overweight; Pathology; Play; Predisposition; Prevalence; Process; Publishing; Research; Risk Assessment; Role; Scientist; Signal Transduction; Time; Toxicology; United States; United States National Institutes of Health; body system; environmental chemical; environmental chemical exposure; exposed human population; in vivo; interest; lectures; malformation; meetings; nutrition; symposium; unpublished works

DESCRIPTION (provided by applicant): A one day satellite symposium, entitled: "Role of Environmental Chemical Exposure in the Etiology of Obesity and the Metabolic Syndrome" will be held in May 24, 2011, in Istanbul, Turkey, in conjunction with the 18th Annual Meeting of the European Association for the Study of Obesity (EASO). The symposium includes 10 invited lectures on various aspects of endocrine disrupting chemicals (EDC) as they impact on obesity and its associated diseases, i.e., the metabolic syndrome, diabetes and cardiovascular complications. An audience of over 100 attendees is expected. The symposium is framed around the following Specific Aims: 1. To bring together national and international leaders in EDC research in a meeting format that promotes debate how to integrate research findings into the risk assessment process. 2. To present the latest developments, including unpublished work, in important areas in EDC research, emphasizing new directions that should guide future research in this area. 3. To discuss the action of endocrine disruptors on multiple organ systems, and the consequences of early and late life exposure, as well as transgenerational components, on the development of obesity and its sequalae. 4. To integrate the strength of evidence derived from studies with cultured cells, laboratory animals and humans, that links EDC exposure to obesity and the metabolic syndrome. 5. To encourage participation of trainees and other young scientists in EDC research. This symposium represents a timely opportunity to bring a very important issue to the forefront of obesity research. It provides venue for presentations by leaders in the field, with ample time for discussions and informal interactions. It is anticipated that a proceeding of the meeting will be published in Cellular and Molecular Endocrinology. The diverse topics and their translational implications that will be covered at this meeting should be of interest not only to the National Institute on Environmental Health Sciences (NIEHS), but also to other NIH institutes with vested interest in the obesity epidemics. These include the National Institute on Diabetes, Digestive and Kidney Disease (NIDDK), the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Child Health and Human Development (NICHD). PUBLIC HEALTH RELEVANCE: This is an R13 application to support a one day satellite symposium on the role of endocrine disruptors in the etiology of obesity and the metabolic syndrome. The meeting will be held on May 24, 2011 in Istanbul, Turkey in conjunction with the 17th European Congress on Obesity.

描述（由申请人提供）：为期一天的卫星研讨会，题为“环境化学暴露在肥胖和代谢综合征病因学中的作用”将于 2011 年 5 月 24 日在土耳其伊斯坦布尔举行，同时举行欧洲肥胖研究协会 (EASO) 第 18 届年会。研讨会包括 10 场特邀讲座，内容涉及内分泌干扰化学物质 (EDC) 的各个方面，因为它们对肥胖及其相关疾病（即代谢综合征、糖尿病和心血管并发症）的影响。预计观众人数将超过 100 人。研讨会围绕以下具体目标： 1. 以会议形式聚集 EDC 研究领域的国家和国际领导人，促进如何将研究成果纳入风险评估过程的辩论。 2. 介绍EDC研究重要领域的最新进展，包括未发表的工作，强调指导该领域未来研究的新方向。 3. 讨论内分泌干扰物对多个器官系统的作用，以及早年和晚年接触内分泌干扰物以及跨代因素对肥胖及其后遗症的影响。 4. 整合来自培养细胞、实验动物和人类研究的证据强度，将 EDC 暴露与肥胖和代谢综合征联系起来。 5. 鼓励学员和其他年轻科学家参与EDC研究。这次研讨会提供了一个及时的机会，将一个非常重要的问题带到肥胖研究的前沿。它为该领域的领导者提供了演讲场所，并有充足的时间进行讨论和非正式互动。预计会议记录将发表在《细胞和分子内分泌学》杂志上。本次会议将讨论的不同主题及其转化意义不仅会引起美国国家环境健康科学研究所 (NIEHS) 的兴趣，也会引起其他对肥胖流行病有既得利益的 NIH 机构的兴趣。其中包括国家糖尿病、消化和肾脏疾病研究所 (NIDDK)、国家心肺和血液研究所 (NHLBI) 以及国家儿童健康和人类发展研究所 (NICHD)。 公共健康相关性：这是一个 R13 应用程序，旨在支持为期一天的卫星研讨会，讨论内分泌干扰物在肥胖和代谢综合征病因学中的作用。该会议将于 2011 年 5 月 24 日在土耳其伊斯坦布尔与第 17 届欧洲肥胖大会同时举行。

项目成果

Method for determining the lung burden of talc in rats and mice after inhalation exposure to talc aerosols.

大鼠和小鼠吸入暴露于滑石气溶胶后确定滑石粉肺负荷的方法。

• DOI: 10.1002/jat.2550050504
• 发表时间: 1985
• 期刊: Journal of applied toxicology : JAT
• 作者: Hanson,RL;Benson,JM;Henderson,TR;Carpenter,RL;Pickrell,JA;Brown,SC
• 通讯作者: Brown,SC

Talc deposition and effects after 20 days of repeated inhalation exposure of rats and mice to talc.

大鼠和小鼠重复吸入滑石粉 20 天后滑石粉沉积和影响。

• DOI: 10.1016/s0013-9351(89)80069-6
• 发表时间: 1989
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Pickrell,JA;Snipes,MB;Benson,JM;Hanson,RL;Jones,RK;Carpenter,RL;Thompson,JJ;Hobbs,CH;Brown,SC
• 通讯作者: Brown,SC