3-D quantitative microwave breast imaging system for comparison with MRI

与 MRI 比较的 3D 定量微波乳腺成像系统

• 批准号: 8166091
• 负责人: SUSAN C HAGNESS
• 金额: $ 15.66万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166091
• 关键词: 3-Dimensional; Algorithms; Benchmarking; Breast; Breast Cancer Detection; Caring; Categories; Clinical; Clinical Engineering; Clinical Research; Collaborations; Comprehensive Cancer Center; Computational algorithm; Data; Data Set; Detection; Engineering; Environment; Evaluation; Frequencies; General Population; Goals; High Risk Woman; High-Risk Cancer; Human Subject Research; Image; Imaging Techniques; Imaging technology; Intervention; Laboratories; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammography; Modality; Molecular; Monitor; Noise; Outcome; Patient Monitoring; Patients; Performance; Physiological; Population; Positioning Attribute; Prevention; Prevention Protocols; Property; Public Health Applications Research; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Assessment; Risk Factors; Safety; Sampling; Scanning; Screening for cancer; Screening procedure; Sensitivity and Specificity; Signal Transduction; Solutions; System; Testing; Three-Dimensional Image; Time; Tissues; Treatment Protocols; Underserved Population; Universities; Validation; Wisconsin; Woman; Women' s Health; Work; base; breast density; cancer risk; clinical application; college; cost; density; design; dielectric property; experience; high risk; human subject; imaging modality; improved; innovation; malignant breast neoplasm; medical schools; meetings; microwave electromagnetic radiation; miniaturize; molecular imaging; prototype; research study; response; sensor; tool

DESCRIPTION (provided by applicant): There is a critical need to develop an affordable, non-ionizing, three-dimensional (3-D) quantitative imaging modality for screening women who are at higher risk for breast cancer and monitoring changes in breast tissue properties in response to treatment protocols. Given increasing recognition of the importance of breast density in individualized risk assessment and prevention decisions, there is also an emerging need to develop such a modality for evaluating breast density in the general population and monitoring changes in density in response to preventative interventions. 3-D microwave imaging - a non-ionizing molecular imaging technique that senses the endogenous (and possibly exogenously influenced) dielectric properties of breast tissue - has great potential to meet these needs. The long-term goal is to develop and integrate microwave imaging into the arsenal of tools available to the breast care clinician. The objective of this project, which is directed toward achieving this long-term goal, is to develop and evaluate a 3-D quantitative microwave imaging system based on advanced sensor hardware, algorithms, and computational platforms and to demonstrate the feasibility of performing a rigorous validation of microwave imaging against breast MRI, a clinical 3-D benchmark. The following specific aims will be pursued to achieve this objective: 1) Construct a compact, efficient 3-D microwave sensor system that enables co-registration with MRI; 2) Develop computationally efficient high- resolution 3-D microwave imaging algorithms that are integrated with the hardware system; and 3) Conduct a small-scale proof-of-concept imaging study with human research subjects. The project is innovative both in terms of the clinical applications and the technical approach. First, breast density evaluation and contrast- enhanced detection of breast cancer represent two new directions for microwave imaging. Second, our non- invasive quantitative microwave imaging system will employ efficient multi-band miniaturized antennas in a dense 3-D array and multi-frequency, physiologically constrained, 3-D inverse scattering algorithms. Most importantly, an innovative system configuration will maintain the position of the breast during both the MRI (benchmark) and microwave (test) scans, enabling an objective and unambiguous validation of microwave breast imaging. The proposed research is significant because it is expected to provide clinical evidence of the efficacy of 3-D microwave breast imaging and ultimately yield an affordable, widely available, and safe imaging solution for automated, quantitative breast density evaluation in the general population and cancer screening in a currently underserved sub-population of women who are known to be at higher risk. PUBLIC HEALTH RELEVANCE: The microwave imaging technology proposed here has demonstrated potential as an affordable, non-ionizing quantitative breast imaging modality that is sensitive to molecular changes in the breast. Important public health applications include breast cancer screening for high-risk patients, monitoring changes in breast tissue properties in response to prevention and treatment protocols, and evaluating breast density in the general population for risk assessment. The outcomes are expected to ultimately have a positive impact on the health of women worldwide, particularly those who are at greatest risk for breast cancer and who are in underserved populations.

描述（由申请人提供）：迫切需要开发一种负担得起的、非电离的、三维（3-D）定量成像方式，用于筛查乳腺癌高风险女性，并监测乳腺组织特性对治疗方案的变化。鉴于人们越来越认识到乳腺密度在个体化风险评估和预防决策中的重要性，因此也需要开发一种模式来评估普通人群的乳腺密度，并监测密度变化以应对预防性干预措施。3-D微波成像——一种非电离分子成像技术，可以感知乳房组织的内源性（也可能是外源性）介电特性——具有满足这些需求的巨大潜力。长期目标是发展和整合微波成像的工具库可用于乳房护理临床医生。为了实现这一长期目标，该项目的目标是开发和评估基于先进传感器硬件、算法和计算平台的3-D定量微波成像系统，并演示微波成像与乳腺MRI（临床3-D基准）进行严格验证的可行性。为实现这一目标，将追求以下具体目标：1)构建一个紧凑、高效的三维微波传感器系统，使其能够与MRI共配准；2)开发与硬件系统集成的计算效率高的高分辨率三维微波成像算法；3)与人类研究对象进行小规模的概念验证成像研究。该项目在临床应用和技术手段上均具有创新性。首先，乳腺密度评估和乳腺癌对比增强检测是微波成像的两个新方向。其次，我们的非侵入性定量微波成像系统将采用密集三维阵列的高效多波段小型化天线和多频率、生理约束的三维逆散射算法。最重要的是，创新的系统配置将在MRI（基准）和微波（测试）扫描期间保持乳房的位置，从而实现微波乳房成像的客观和明确的验证。这项研究具有重要意义，因为它有望为三维微波乳房成像的有效性提供临床证据，并最终为普通人群的自动定量乳房密度评估和目前已知风险较高的妇女亚群中服务不足的癌症筛查提供一种经济、广泛可用和安全的成像解决方案。