Tumor Microenvironment/Angiogenesis Training Grant

肿瘤微环境/血管生成培训补助金

• 批准号: 8069951
• 负责人: DEBABRATA MUKHOPADHYAY
• 金额: $ 23.23万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8069951
• 关键词: Grant; Training; angiogenesis; tumor

DESCRIPTION (provided by applicant): Accumulating evidence has shown that the tumor microenvironment is critically important for the initiation and progression of cancer. The tumor microenvironment consists of several components including tumor cells, myofibroblasts, stellate cells, peritumor nerve cells, endothelial cells, immune cells and endocrine cells, as well as extracellular components such as the extracellular matrix. While it is recognized that these components are mediators of tumorigenesis, the complex interplay of these components is poorly understood. Research efforts to investigate the mechanisms of tumor microenvironment interactions in the primary tumor site and organs that are common sites of metastatic lesions are critically needed in order to identify potential targets for improved cancer treatment, as well as risk management and prevention. Hence, we believe that there is a clear need for new programs to train individuals at the graduate as well as the postgraduate levels to understand and efficiently investigate the complex processes that contribute to the conversion of normal stromal cells to an active tumor microenvironment that leads to tumor progression and metastasis. This proposal requests funding to support is 8 trainees (2 predoctoral, 6 postdoctoral) each year for 5 years The program objective is to provide integrated training to individuals who will conduct critically needed research investigating the molecular and cellular anomalies of tumor microenvironment components that result in tumor initiation, progression, metastasis, and relapse. The program is based on the idea that major progress, of clinical relevance, in the area of stromal and epithelial dysfunction of cancer formation will be enhanced by a concerted effort of investigators who have had substantial mentoring and experience in the fields of cell biology, vascular cell biology, extracellular matrix biology, cancer genetics, immunology, and clinical cancer research. The Tumor Microenvironment/Angiogenesis (TMA) Training Program involves 25 full faculty members, all of whom have extramurally supported programs and expertise in TMA-related areas. Dr. Mukhopadhyay will serve as director of the program. He is an experienced mentor and training program leader. He will be assisted by Dr. Mark McNiven, who is known world-wide for his expertise in cell biology and he has an outstanding training record. RELEVANCE: Despite the tremendous advancements in the diagnosis and treatment of cancer, we are far from achieving our optimal goal to "eradicate cancer." This training program will program will provide the next generation of cancer researchers with an integrated set of skills needed to understand the complex interactions of tumor cells and the cells surrounding them. This knowledge will be used to improve cancer prevention and treatment methods.

描述（由申请人提供）：积累的证据表明，肿瘤微环境对于癌症的启动和进展至关重要。肿瘤微环境由几个成分组成，包括肿瘤细胞，肌纤维细胞，星状细胞，周围神经细胞，内皮细胞，免疫细胞和内分泌细胞以及细胞外成分，例如细胞外基质。尽管这些成分是肿瘤发生的介体，但这些成分的复杂相互作用知之甚少。为了确定改善癌症治疗的潜在靶标，以及风险管理和预防的潜在靶标，非常需要研究原发性肿瘤部位和作为转移性病变的常见部位的肿瘤微环境相互作用机制的研究工作。因此，我们认为，显然需要新的计划来培训毕业生的个体以及研究生水平，以理解并有效地研究了有助于正常基质细胞转化为活性肿瘤微环境的复杂过程，从而导致肿瘤进展和转移。 该提案要求提供资金支持的资金为5年的8名受训者（2个占主导地位，6个博士后），该计划的目标是为那些将进行综合培训，向那些将进行迫切需要研究的个人，研究肿瘤微环境成分的分子和细胞异常，从而导致肿瘤开始，肿瘤起动，进展，进展，转移，转移，转移，转移和相关性。该计划基于这样的想法：临床相关性的主要进步，在癌症形成的基质和上皮功能障碍领域将通过在细胞生物学，血管生物学，细胞生物学，外细胞生物学，癌症遗传学，癌症，临床癌症和临床癌症研究领域进行丰富的指导和经验的努力来增强癌症形成的领域。 肿瘤微环境/血管生成（TMA）培训计划涉及25名完整的教职员工，所有这些成员都在与TMA相关地区的计划外支持和专业知识。 Mukhopadhyay博士将担任该计划的主任。他是一位经验丰富的导师和培训计划负责人。 Mark McNiven博士将为他提供协助，Mark McNiven博士以其细胞生物学专业知识而闻名，并且拥有出色的培训记录。 相关性：尽管在癌症的诊断和治疗方面取得了巨大进步，但我们并没有实现“消除癌症”的最佳目标。该培训计划将计划为下一代癌症研究人员提供一组综合的技能，以了解肿瘤细胞和周围细胞的复杂相互作用。这些知识将用于改善预防癌症和治疗方法。