Tumor Microenvironment/Angiogenesis Training Grant

肿瘤微环境/血管生成培训补助金

• 批准号: 8259210
• 负责人: DEBABRATA MUKHOPADHYAY
• 金额: $ 26.8万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259210
• 关键词: Grant; Training; angiogenesis; tumor

DESCRIPTION (provided by applicant): Accumulating evidence has shown that the tumor microenvironment is critically important for the initiation and progression of cancer. The tumor microenvironment consists of several components including tumor cells, myofibroblasts, stellate cells, peritumor nerve cells, endothelial cells, immune cells and endocrine cells, as well as extracellular components such as the extracellular matrix. While it is recognized that these components are mediators of tumorigenesis, the complex interplay of these components is poorly understood. Research efforts to investigate the mechanisms of tumor microenvironment interactions in the primary tumor site and organs that are common sites of metastatic lesions are critically needed in order to identify potential targets for improved cancer treatment, as well as risk management and prevention. Hence, we believe that there is a clear need for new programs to train individuals at the graduate as well as the postgraduate levels to understand and efficiently investigate the complex processes that contribute to the conversion of normal stromal cells to an active tumor microenvironment that leads to tumor progression and metastasis. This proposal requests funding to support is 8 trainees (2 predoctoral, 6 postdoctoral) each year for 5 years The program objective is to provide integrated training to individuals who will conduct critically needed research investigating the molecular and cellular anomalies of tumor microenvironment components that result in tumor initiation, progression, metastasis, and relapse. The program is based on the idea that major progress, of clinical relevance, in the area of stromal and epithelial dysfunction of cancer formation will be enhanced by a concerted effort of investigators who have had substantial mentoring and experience in the fields of cell biology, vascular cell biology, extracellular matrix biology, cancer genetics, immunology, and clinical cancer research. The Tumor Microenvironment/Angiogenesis (TMA) Training Program involves 25 full faculty members, all of whom have extramurally supported programs and expertise in TMA-related areas. Dr. Mukhopadhyay will serve as director of the program. He is an experienced mentor and training program leader. He will be assisted by Dr. Mark McNiven, who is known world-wide for his expertise in cell biology and he has an outstanding training record. RELEVANCE: Despite the tremendous advancements in the diagnosis and treatment of cancer, we are far from achieving our optimal goal to "eradicate cancer." This training program will program will provide the next generation of cancer researchers with an integrated set of skills needed to understand the complex interactions of tumor cells and the cells surrounding them. This knowledge will be used to improve cancer prevention and treatment methods.

描述（由申请人提供）：越来越多的证据表明，肿瘤微环境对癌症的发生和发展至关重要。肿瘤微环境包括肿瘤细胞、肌成纤维细胞、星状细胞、瘤周神经细胞、内皮细胞、免疫细胞和内分泌细胞等成分，以及细胞外基质等细胞外成分。虽然人们认识到这些成分是肿瘤发生的介质，但对这些成分的复杂相互作用知之甚少。研究肿瘤微环境在原发肿瘤部位和转移性病变常见部位的相互作用机制是迫切需要的，以便确定改善癌症治疗的潜在靶点，以及风险管理和预防。因此，我们认为显然需要新的项目来培养研究生和研究生水平的个人，以理解和有效地研究导致正常基质细胞转化为活性肿瘤微环境的复杂过程，从而导致肿瘤的进展和转移。