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The Role of Self-Expansion as a Potential Aid in Smoking Cessation

自我扩张作为戒烟的潜在帮助的作用

基本信息

批准号：
8015309
负责人：
Xiaomeng Xu
金额：
$ 1.64万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-01-14 至 2011-07-13
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8015309
关键词：
Acquaintances Affect Anterior Area Basal Ganglia Behavioral Brain Brain region Bupropion Chemicals China Cigarette Consult Corpus striatum structure Couples Dopamine Dorsal Drug Addiction Feeling Foundations Functional Magnetic Resonance Imaging Health Personnel Image Knowledge Lead Link Location Measures Methods Modeling Neurons Neuropsychology Nicotine Nicotine Dependence Nucleus Accumbens Partner in relationship Pathway interactions Patient Self-Report Pattern Persons Pharmaceutical Preparations Process Psychologist Public Health Reporting Research Resources Rewards Role Series Smoker Smoking Social Environment Social Functioning Social Psychology Sum Supervision System Testing Thinking Time Ursidae Family Ventral Tegmental Area addiction base cingulate cortex combat cost craving drug craving experience frontal lobe mesolimbic system neuroimaging neuromechanism nicotine craving novel novel strategies programs relating to nervous system research study response skills smoking cessation social social neuroscience uptake

项目摘要

DESCRIPTION (provided by applicant): The proposed research focuses on the hypothesized overlap between the craving and reward experienced during nicotine addiction and the craving and reward experienced in social self-expansion in the context of close relationships. A series of two functional Magnetic Resonance Imaging (fMRI) experiments are proposed to examine whether nicotine and self-expansion (as elicited by novelty and challenge in the context of forming and maintaining close relationships) engage the same neural systems (namely the mesolimbic system, which utilize dopamineric pathways and include areas in the basal ganglia such as the caudate and the ventral segmental area) such that the reward of social self-expansion can substitute for the reward of nicotine and thus lower a smoker's craving for a cigarette. Study 1 will be conducted in China and Study 2 will be conducted in U.S. I chose these locations not only because of a successful previous study done in China, but because I believe in the importance of cross-cultural research, particularly in China where the smoking rate is significantly higher and where public knowledge of the dangers of smoking and smoking cessation programs are much less available. The theoretical foundation and procedural details of each study are grounded in previously conducted studies, yet the proposed research goes beyond anything previously done to bridge a gap between the the neural mechanisms of addiction and the social psychology of close relationships. I will conduct this research under the close supervision of Dr. Arthur Aron, an expert on social self-expansion and will consult with Dr. Lee Westmaas, an expert in nicotine addiction. Dr. Xuchu Weng, a neuroimaging and neuropsychology expert. Dr. Lucy Brown, an expert on the basal ganglia, and Dr. Rita Goldstein, an expert on neuroimaging and drug addiction. I believe this research has the potential to significantly advance basic scientific understanding in previous entirely untested ways for neuroscientists studying addictions and basal ganglia function and for social psychologists studying the motivational basis of addictions and relationship processes. This research will also determine the feasibility of a dramatically different, entirely novel approach to undermining addiction to nicotine. Thus, this research would benefit public health by examining basic processes that could lead to whole new methods for smoking cessation, including specifically testing one such method that would be easily accessible to many people, and one that could be implemented by the smokers themselves without need for medical personnel, prescriptions, or expensive facilities. Further, the method would be no to low cost and would also lead to relationship benefits for couples who choose to use it.

描述（由申请人提供）：拟议的研究重点是尼古丁成瘾期间经历的渴望和奖励与亲密关系背景下社会自我扩张中经历的渴望和奖励之间的假设重叠。一系列的两个功能性磁共振成像（fMRI）实验被提出来检查尼古丁和自我膨胀是否（如在形成和维持密切关系的背景下由新奇和挑战引起的）参与相同的神经系统（即中边缘系统，其利用多巴胺途径并包括基底神经节中的区域，例如尾状核和腹侧节段区域）这样，社会自我扩张的回报就可以取代尼古丁的回报，从而降低吸烟者对香烟的渴望。研究1将在中国进行，研究2将在美国进行。我选择这些地点不仅是因为之前在中国进行的一项成功的研究，还因为我相信跨文化研究的重要性，特别是在中国，吸烟率明显较高，公众对吸烟危害和戒烟计划的了解要少得多。每项研究的理论基础和程序细节都基于以前进行的研究，但拟议的研究超越了以前所做的任何工作，以弥合成瘾的神经机制和亲密关系的社会心理之间的差距。我将在亚瑟·阿伦博士的密切监督下进行这项研究，他是一位社会自我扩张方面的专家，我还将咨询尼古丁成瘾方面的专家李·韦斯特马斯博士。神经影像学和神经心理学专家翁旭初博士。露西·布朗博士，基底神经节专家，丽塔·戈尔茨坦博士，神经成像和药物成瘾专家。我相信这项研究有可能以以前完全未经测试的方式显着推进基本的科学理解，神经科学家研究成瘾和基底神经节功能，社会心理学家研究成瘾和关系过程的动机基础。这项研究还将确定一种截然不同的、全新的方法来削弱尼古丁成瘾的可行性。因此，这项研究将通过检查可能导致戒烟的全新方法的基本过程来有益于公共健康，包括专门测试一种对许多人来说很容易获得的方法，以及一种可以由吸烟者自己实施而不需要医务人员，处方或昂贵设施的方法。此外，这种方法成本低，也会为选择使用它的夫妇带来关系上的好处。