Novel Translational Approaches to BPH/LUTS

良性前列腺增生症(BPH)或下尿路症状(LUTS)是美国老年男性最常见的疾病之一。这些都是复杂的疾病，需要分子分类和新的治疗方法。为了满足这些需求，我们为乔治·M·奥布莱恩泌尿外科中心准备了这份申请，该中心专注于BPH/LUTS。该中心由四个项目组成，每个项目都是翻译/临床项目。项目1的标题是，下尿路症状的病因学中的前列腺内炎症。项目2在JM27上作为潜在的生物标志物 症状性前列腺增生症。项目3涉及良性前列腺增生症的遗传相关性研究。这三个项目得到侧重于生物统计的一个行政核心和一个生物资源核心的支持。行政核心包括中心支持结构的要素，以及试点和可行性及教育充实方案。这个奥布莱恩中心应该为这些影响几乎所有男性随着年龄增长的共同问题提供新的见解和方法。

Benign Prostatic Hyperplasia (BPH) or Lower Urinary Tract Symptoms (LUTS) represents one of the most common diseases occurring in aging men in the United States. These are complex diseases that require molecular classification and novel therapeutic approaches. To address these needs, we have prepared this application for a George M. O'Brien Urology Center which is focused on BPH/LUTS. The Center consists of four projects each of which is translational/clinical in nature. Project 1 is entitled, Intraprostatic Inflammation in the Etiology of Lower Urinary Tract Symptoms. Project 2 is on JM27 as a Potential Biomarker of Symptomatic BPH. Project 3 relates to Genetic Association Studies in BPH. These three projects are supported by an Administrative and a Bioresource Cores focused on biostatistics. The Administrative Core contains elements of the supporting structure for the Center along with the Pilot and Feasibility and Educational Enrichment Programs. This O'Brien Center should provide new insights and approaches to these common issues that effect almost all men as they age.