Novel Translational Approaches to BPH/LUTS

良性前列腺增生（BPH）或下尿路症状（LUTS）是美国老年男性中最常见的疾病之一。这些都是复杂的疾病，需要分子分类和新的治疗方法。为了满足这些需求，我们为乔治·m·奥布莱恩泌尿外科中心准备了这份申请，该中心专注于BPH/LUTS。该中心由四个项目组成，每个项目都是转化/临床性质的。课题一的题目是：前列腺内炎症与下尿路症状的病因学关系。项目二是JM27作为一种潜在的生物标志物

Benign Prostatic Hyperplasia (BPH) or Lower Urinary Tract Symptoms (LUTS) represents one of the most common diseases occurring in aging men in the United States. These are complex diseases that require molecular classification and novel therapeutic approaches. To address these needs, we have prepared this application for a George M. O'Brien Urology Center which is focused on BPH/LUTS. The Center consists of four projects each of which is translational/clinical in nature. Project 1 is entitled, Intraprostatic Inflammation in the Etiology of Lower Urinary Tract Symptoms. Project 2 is on JM27 as a Potential Biomarker of Symptomatic BPH. Project 3 relates to Genetic Association Studies in BPH. These three projects are supported by an Administrative and a Bioresource Cores focused on biostatistics. The Administrative Core contains elements of the supporting structure for the Center along with the Pilot and Feasibility and Educational Enrichment Programs. This O'Brien Center should provide new insights and approaches to these common issues that effect almost all men as they age.