Novel Translational Approaches to BPH/LUTS

BPH/LUTS 的新颖转化方法

• 批准号: 8150218
• 负责人: Robert H. Getzenberg
• 金额: $ 3.24万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8150218
• 关键词: Address; Age; Aging; Benign Prostatic Hypertrophy; Biological Markers; Biometry; Classification; Clinical; Complex; Disease; Elements; Etiology; Inflammation; Molecular; Nature; Structure; United States; Urology; genetic association; insight; lower urinary tract symptoms; men; novel; novel therapeutic intervention; programs; translational approach

Benign Prostatic Hyperplasia (BPH) or Lower Urinary Tract Symptoms (LUTS) represents one of the most common diseases occurring in aging men in the United States. These are complex diseases that require molecular classification and novel therapeutic approaches. To address these needs, we have prepared this application for a George M. O'Brien Urology Center which is focused on BPH/LUTS. The Center consists of four projects each of which is translational/clinical in nature. Project 1 is entitled, Intraprostatic Inflammation in the Etiology of Lower Urinary Tract Symptoms. Project 2 is on JM27 as a Potential Biomarker of Symptomatic BPH. Project 3 relates to Genetic Association Studies in BPH. These three projects are supported by an Administrative and a Bioresource Cores focused on biostatistics. The Administrative Core contains elements of the supporting structure for the Center along with the Pilot and Feasibility and Educational Enrichment Programs. This O'Brien Center should provide new insights and approaches to these common issues that effect almost all men as they age.

良性前列腺增生（BPH）或下尿路症状（LUTS）是美国老年男性最常见的疾病之一。这些是复杂的疾病，需要分子分类和新的治疗方法。为了满足这些需求，我们准备了乔治M的申请。奥布莱恩泌尿外科中心，专注于BPH/LUTS。该中心由四个项目组成，每个项目都是翻译/临床性质的。项目1的题目是：下尿路症状病因学中的前列腺内炎症。项目2是关于JM 27作为潜在的生物标志物， BPH症状。项目3涉及BPH的遗传关联研究。这三个项目得到了侧重于生物统计学的行政核心和生物资源核心的支持。行政核心包括中心的支持结构要素沿着试点和可行性方案和教育充实方案。这个奥布莱恩中心应该提供新的见解和方法，这些共同的问题，影响几乎所有的男人，因为他们的年龄。