Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy

Lowe 综合征肾病的 BAC 转基因和敲除小鼠模型相结合

• 批准号: 8081385
• 负责人: ROBERT L NUSSBAUM
• 金额: $ 15.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8081385
• 关键词: Accounting; Actins; Affect; Affinity; Age; Age-Months; American Society of Hematology; Amino Acids; Animal Testing; Animals; Antibodies; Anxiety; Apical; Bacterial Artificial Chromosomes; Behavioral; Binding; Brain; Cataract; Cell Culture Techniques; Cell membrane; Cells; Chloride Channels; Clathrin; Control Animal; Creatinine clearance measurement; Cues; Cytoskeleton; Defect; Diamino Amino Acids; Disease; Distal; Embryo; Endocytosis; Endosomes; Enzymes; Excretory function; Financial compensation; Foundations; Functional disorder; Future; Genes; Genetic Transcription; Golgi Apparatus; Growth; Human; Immunofluorescence Immunologic; Kidney; Kidney Diseases; Knock-out; Knockout Mice; LDL-Receptor Related Protein 2; Lead; Learning; Link; Measures; Mediating; Membrane; Memory; Mental Retardation; Modeling; Molecular Weight; Morphology; Motor; Motor Activity; Mus; Mutation; Neuraxis; Neurologic; Oculocerebrorenal Syndrome; Orthologous Gene; Patients; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Primary Cell Cultures; Proteins; Proteinuria; RNA Splicing; Rare Diseases; Recycling; Renal function; Renal tubule structure; Research Design; Resistance; Structure; Syndrome; Testing; Time; Transgenic Mice; Transgenic Organisms; Tubular formation; Urine; X Chromosome; base; coated pit; conditioning; congenital cataract; disease-causing mutation; drug testing; genetic manipulation; in vivo; inorganic phosphate; inositol-1,4,5-trisphosphate 5-phosphatase; intrinsic factor-cobalamin receptor; kidney cell; lens; light microscopy; loss of function mutation; male; morris water maze; mouse model; profilin; receptor; rho; small molecule; trafficking; trans-Golgi Network; transmission process; uptake; urinary