Understanding the biology of schistosomes in response to praziquantel
Understanding the biology of schistosomes in response to praziquantel
批准号:
8132753
负责人:
Charles Cunningham
金额:
$39.43万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-09-15 至 2011-06-30
关键词:
ActinsAdolescentAfricaAfricanAlkynesBase SequenceBindingBiochemical PathwayBiological AssayBiologyCandidate Disease GeneChemistryDataDetectionDevelopmentDiazomethaneDoseDown-RegulationDrug Metabolic DetoxicationDrug effect disorderDrug resistanceEngineeringEnsureGene ExpressionGene Expression ProfileGene TargetingGenerationsGenesGlutathioneGoalsHumanIn VitroInfectionKenyaKnowledgeLaboratoriesLifeLife Cycle StagesMeta-AnalysisMethodsMolecularMolecular TargetMonitorMothersMusMutationMyosin Light ChainsParasitic DiseasesPathway interactionsPatientsPatternPharmaceutical PreparationsPhenotypePlayPopulationPopulation HeterogeneityPraziquantelPraziquantel resistancePredispositionPurinergic P1 ReceptorsRNA InterferenceReporterReportingResistanceRoleSchistosomaSchistosoma mansoniSchistosomiasisSporocystsTestingTherapeuticTimeTranscriptTropical DiseaseVariantWorkactivity-based protein profilinganalogbasecohortcombatcrosslinkexperienceimprovedinnovationinsightinterestkillingsknock-downneglectnovelnovel therapeuticspharmacophorepublic health relevanceresponsesexsmall molecule librariestheoriestrait
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel.
设计和合成用于确定驱虫药吡喹酮靶标的分子探针。
DOI:
10.1016/j.bmcl.2014.04.014
发表时间:
2014
期刊:
Bioorganic & medicinal chemistry letters
影响因子:
2.7
作者:
[Sharma,LalitKumar, Cupit,PaulineM, Goronga,Tino, Webb,ThomasR, Cunningham,Charles]
通讯作者:
Cunningham,Charles
DOI:
10.1016/j.molbiopara.2012.09.006
发表时间:
2012-12
期刊:
Molecular and biochemical parasitology
影响因子:
1.5
作者:
[Hines-Kay J, Cupit PM, Sanchez MC, Rosenberg GH, Hanelt B, Cunningham C]
通讯作者:
Cunningham C
Understanding the biology of schistosomes in response to praziquantel
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批准号:8501265
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项目类别:
-
资助金额:$35.99万
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财政年份:2011
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负责人:Charles Cunningham
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依托单位:
Understanding the biology of schistosomes in response to praziquantel
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批准号:8294520
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项目类别:
-
资助金额:$38.28万
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财政年份:2011
-
负责人:Charles Cunningham
-
依托单位:
Understanding the biology of schistosomes in response to praziquantel
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批准号:8041591
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项目类别:
-
资助金额:$32.97万
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财政年份:2011
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负责人:Charles Cunningham
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依托单位:
SCHISTOSOMA MANSONI DEFENSE GENES: IDENTIFICATION AND EXPLOITATION IN THE DEVELO
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批准号:8360209
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项目类别:
-
资助金额:$11.88万
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财政年份:2011
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负责人:Charles Cunningham
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依托单位:
Understanding the biology of schistosomes in response to praziquantel
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批准号:8678828
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项目类别:
-
资助金额:$38.28万
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财政年份:2011
-
负责人:Charles Cunningham
-
依托单位:
SCHISTOSOMA MANSONI DEFENSE GENES: IDENTIFICATION AND EXPLOITATION IN THE DEVELO
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批准号:8168269
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项目类别:
-
资助金额:$20.35万
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财政年份:2010
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负责人:Charles Cunningham
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依托单位:
EXPRESSION PROFILING OF DEFENSE AND STRESS RELATED GENES OF SCHISTOSOMA MANSONI
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批准号:7960519
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项目类别:
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资助金额:$23.06万
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财政年份:2009
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负责人:Charles Cunningham
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依托单位:
Cell Biology Core
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批准号:8751178
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项目类别:
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资助金额:$9.79万
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财政年份:--
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负责人:Charles Cunningham
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依托单位:
海外基金