Cerebral Aneurysm Clipping Training Simulator using Virtual Reality and Haptics

使用虚拟现实和触觉的脑动脉瘤夹闭训练模拟器

• 批准号: 7903697
• 负责人: P. PAT BANERJEE
• 金额: $ 19.99万
• 依托单位: IMMERSIVETOUCH, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903697
• 关键词: Acoustic Neuroma; Algorithms; Aneurysm; Angiography; Anterior; Arteries; Attention; Blood flow; Brain Neoplasms; Businesses; Capsulorhexis; Carotid Cistern; Cataract Extraction; Catheters; Cerebral Aneurysm; Cerebrum; Chicago; Cholecystectomy; Clip; Collaborations; Craniotomy; Data; Engineering; Ensure; Evaluation; Excision; Funding; Goals; Head; Illinois; Indium; Internal carotid artery structure; Intervention; Intracranial Aneurysm; Legal patent; Licensing; Location; Marketing; Measures; Middle Cerebral Artery Aneurysm; Modeling; National Institute of Biomedical Imaging and Bioengineering; Neck; Neurosurgeon; Neurosurgical Procedures; Operating Rooms; Operative Surgical Procedures; Ophthalmology; Patients; Phase; Physicians; Prevention; Puncture procedure; Research; Risk; Simulate; Small Business Technology Transfer Research; Software Engineering; Spinal; Stroke; Subarachnoid Hemorrhage; Sylvius fissure; System; Technology; Testing; Time; Training; Translating; United States Agency for Healthcare Research and Quality; Universities; Ventricular; Ventriculostomy; Virtual Reality Medical Imaging; Work; brain tissue; experience; haptics; innovation; middle cerebral artery; neurosurgery; professor; programs; prototype; public health relevance; research and development; research clinical testing; simulation; skills; stem; three-dimensional modeling; virtual reality

DESCRIPTION (provided by applicant): ImmersiveTouch, Inc. (Westmont, Illinois) is a small business that develops fully immersive, visio-haptic virtual reality software engineered into a hardware workstation for the training of surgical residents. This workstation, the Company's simulator seeks to provide residents with the repeated, deliberate virtual reality practice that will give them skills for the operating room without risk to patients. ImmersiveTouch R&D relies on a close university-company Partnership: Dr. Banerjee, a professor of Engineering at University of Illinois at Chicago (UIC), is one of the inventors on the patent-pending ImmersiveTouch technology and the patent is assigned to UIC, which licenses the technology to ImmersiveTouch, Inc. A collaborator on this proposal and co-owner of ImmersiveTouch, Dr. Fady Charbel, is head of Neurosurgery at UIC and the inventor of the Charbel Micro- Flowprobe for intracranial surgery, which has been successfully marketed by Transonic Systems, Inc. Today, about 85% of intracranial aneurysms are treated endovascularly, e.g., by aneurysm coiling. There are already commercial virtual reality trainers for aneurysm coiling, such as the Mentice VIST". This means that today, only 15% of cerebral aneurysms are treated by open craniotomy and aneurysm clipping as pioneered by M. G. Yasargil. There is insufficient training time and patient load for residents to be trained or for many attending physicians to retain their skill level in aneurysm clipping. There is no validated simulator for this. The goal of this STTR Phase I application is to produce a new simulation of cerebral aneurysm clipping for training neurosurgeons in the treatment or prevention of subarachnoid hemorrhage and other forms of stroke. ImmersiveTouch already has experience in neurosurgery simulation, having perfected a simulator for ventricular catheter placement (funded by NIST). This simulation has been tested for its construct validity (the simulator accurately measures different levels of OR experience) and is currently funded by the AHRQ for clinical evaluation of its concurrent validity, testing whether simulator skills in ventriculostomy actually translate to the operating room. Within neurosurgery, the Company also has a prototype simulation of pedicle screw placement in spinal surgery funded by NIBIB (R21), and plans to simulate removal of specific brain tumors (e.g., acoustic neuromas). The Company is also active in ophthalmology, with a simulator for capsulorhexis during cataract surgery funded by NEI, and is working on open cholecystectomy. Selection of the particular cerebral aneurysm for simulation. About 80% of the cerebral aneurysms requiring intervention form on arteries that arise from the internal carotid artery: anterior cerebral, anterior communicating, posterior communicating, and middle cerebral artery (MCA). While Phase II of this STTR may focus on aneurysms on all these arteries, Phase I is a proof-of-concept. Therefore for illustration, the proposal focuses on an aneurysm at the bifurcation of the MCA, where its main stem, M1, branches into two secondary arteries, M2 (another aneurysm could be chosen for the final model). This location can be reached by creating an opening in the Sylvian fissure. The two major parts of the surgery are therefore opening the Sylvian fissure to reach the aneurysm and then clipping the aneurysm to ensure that it is fully isolated from the main blood flow and that no surrounding arteries have been accidentally clipped. PUBLIC HEALTH RELEVANCE: ImmersiveTouch Inc. develops innovative augmented virtual reality systems for training of neurosurgical residents. In collaboration with the University of Illinois at Chicago, the Partnership proposes to conduct research to overcome some of the current technical barriers. If successful, following STTR Phases I and II, the ImmersiveTouch-SENSIMMER Neurosurgical Trainer will overcome challenges leading to evaluation of cerebral aneurysm clipping and other derivative neurosurgical procedures,

描述（由申请人提供）： ImmersiveTouch，Inc.（韦斯特蒙，伊利诺伊州）是一家小企业，开发完全沉浸式的触觉虚拟现实软件，该软件被设计成硬件工作站，用于培训外科住院医生。这个工作站，该公司的模拟器旨在为居民提供重复的，故意的虚拟现实实践，这将使他们的技能，为手术室没有风险的病人。ImmersiveTouch的研发依赖于紧密的大学-公司合作关系：Banerjee博士是伊利诺伊大学芝加哥分校（UIC）的工程学教授，他是ImmersiveTouch技术的发明人之一，该专利已转让给UIC，UIC将该技术授权给ImmersiveTouch，Inc.。该提案的合作者兼ImmersiveTouch的共同所有者Fady Charbel博士是UIC神经外科负责人，也是用于颅内手术的Charbel微型流量探针的发明者，该探针已由Transonic Systems，Inc.成功销售。如今，约85%的颅内动脉瘤是血管内治疗的，例如，通过动脉瘤弹簧圈。已经有用于动脉瘤弹簧圈栓塞术的商业虚拟现实训练器，例如Mentice VIST。这意味着今天，只有15%的脑动脉瘤采用M。G.亚萨吉尔住院医师的培训时间和患者负荷不足，许多主治医生无法保持其动脉瘤夹闭术的技能水平。没有经过验证的模拟器。该STTR I期应用的目标是产生一种新的脑动脉瘤夹闭模拟，用于培训神经外科医生治疗或预防蛛网膜下腔出血和其他形式的卒中。ImmersiveTouch已经在神经外科模拟方面有经验，已经完善了脑室导管放置模拟器（由NIST资助）。该模拟已经过结构有效性测试（模拟器准确测量不同水平的手术室经验），目前由AHRQ资助，用于其并行有效性的临床评价，测试脑室造口术模拟器技能是否实际转化为手术室。在神经外科领域，该公司还拥有由NIBIB（R21）资助的脊柱手术中椎弓根螺钉放置的原型模拟，并计划模拟特定脑瘤的切除（例如，听神经瘤）。该公司还活跃在眼科领域，在NEI资助的白内障手术中使用模拟撕囊术，并致力于开放式胆囊切除术。选择特定的脑动脉瘤进行模拟。约80%需要介入治疗的脑动脉瘤形成于颈内动脉的动脉上：大脑前动脉、前交通动脉、后交通动脉和大脑中动脉（MCA）。虽然该STTR的II期可能侧重于所有这些动脉上的动脉瘤，但I期是概念验证。因此，为了举例说明，该提案侧重于MCA分叉处的动脉瘤，其中其主干M1分支成两个次级动脉M2（可以选择另一个动脉瘤用于最终模型）。这个位置可以通过在大脑外侧裂中创建一个开口来到达。因此，手术的两个主要部分是打开侧裂以到达动脉瘤，然后夹闭动脉瘤以确保其与主血流完全隔离，并且没有意外夹闭周围动脉。 公共卫生相关性： ImmersiveTouch Inc.开发创新的增强虚拟现实系统，用于培训神经外科住院医师。该伙伴关系与位于芝加哥的伊利诺伊大学合作，提议开展研究，以克服目前的一些技术障碍。如果成功，在STTR I期和II期之后，ImmersiveTouch-SENSIMMER神经外科培训器将克服导致脑动脉瘤夹闭术和其他衍生神经外科手术评价的挑战，

项目成果

Virtual reality cerebral aneurysm clipping simulation with real-time haptic feedback.

• DOI: 10.1227/neu.0000000000000583
• 发表时间: 2015-03
• 期刊: Neurosurgery
• 影响因子: 4.8
• 作者: Alaraj A;Luciano CJ;Bailey DP;Elsenousi A;Roitberg BZ;Bernardo A;Banerjee PP;Charbel FT
• 通讯作者: Charbel FT