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Human Cathelicidin-Based Novel Antimicrobial Peptides

Human Cathelicidin-Based Novel Antimicrobial Peptides
基于人导管素的新型抗菌肽
批准号：
8116778
负责人：
GUANGSHUN WANG
金额：
$29.7万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-08-16 至 2012-03-31
来源：
https://reporter.nih.gov/project-details/8116778
关键词：
AIDS/HIV problemAcquired Immunodeficiency SyndromeAdverse effectsAmino AcidsAreaAthleticBacillus anthracisBacteriaBiological AssayC-terminalCAP18 lipopolysaccharide-binding proteinCause of DeathCellsCessation of lifeChargeChemotaxisClinicalCommunicable DiseasesCommunitiesCytolysisDataDatabasesDepositionDevelopmentDrug resistanceEngineeringEscherichia coliEvaluationFeedbackFutureGoalsHospitalsHost DefenseHot SpotHumanHuman ActivitiesHydrophobicityImmune responseInfectionLeadLegal patentLengthLettersLipidsLysineMembraneMethicillin ResistanceMicellesModelingModificationMolecular ConformationMusNMR SpectroscopyNative AmericansNuclear Magnetic ResonanceNursing HomesOutcomeOutcome StudyPatternPeptide HydrolasesPeptidesPhosphatidyl glycerolPhosphatidylglycerolsPopulationPropertyProtocols documentationPublishingRecombinantsResearchResistanceResistance developmentRight-OnRoleSchoolsSeminalSideStaphylococcus aureusStructureStructure-Activity RelationshipStudentsSurfaceSystemTestingTextTherapeuticTherapeutic IndexToxic effectUnited StatesUnited States National Institutes of HealthUpdateVertebral columnWorkantimicrobialantimicrobial drugantimicrobial peptidebacterial resistancebasecathelicidinchemokinecytotoxicitydensitydesignimmunoregulationimprovedin vivoinnovationinsightinterestkillingsmeetingsmembrane modelmethicillin resistant Staphylococcus aureusmimeticsmouse modelmutantnatural antimicrobialnovelnovel therapeuticspathogenpathogenic bacteriapre-clinicalpublic health relevanceresearch studyresistant strainscaffoldtherapeutic targetthree dimensional structurewardweapons

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期刊论文(6)
专著(0)
科研奖励(0)
会议论文
Ab initio design of potent anti-MRSA peptides based on database filtering technology.
DOI： 10.1021/ja305644e
发表时间： 2012-08-01
期刊： Journal of the American Chemical Society
影响因子： 15
作者： [Mishra B, Wang G]
通讯作者： Wang G
Insights into Antimicrobial Peptides from Spiders and Scorpions.
DOI： 10.2174/0929866523666160511151320
发表时间： 2016
期刊： Protein and peptide letters
影响因子： 1.6
作者： [Wang X, Wang G]
通讯作者： Wang G
The Importance of Amino Acid Composition in Natural AMPs: An Evolutional, Structural, and Functional Perspective.
DOI： 10.3389/fimmu.2012.00221
发表时间： 2012
期刊： Frontiers in immunology
影响因子： 7.3
作者： [Mishra B, Wang G]
通讯作者： Wang G
Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37.
DOI： 10.1039/c3ra42599a
发表时间： 2013-11-14
期刊： RSC advances
影响因子： 3.9
作者： [Mishra B, Epand RF, Epand RM, Wang G]
通讯作者： Wang G
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic Wounds
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic Wounds
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic Wounds
Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic Wounds
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