Human Cathelicidin-Based Novel Antimicrobial Peptides

基于人导管素的新型抗菌肽

• 批准号: 8116778
• 负责人: GUANGSHUN WANG
• 金额: $ 29.7万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-16 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116778
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adverse effects; Amino Acids; Area; Athletic; Bacillus anthracis; Bacteria; Biological Assay; C-terminal; CAP18 lipopolysaccharide-binding protein; Cause of Death; Cells; Cessation of life; Charge; Chemotaxis; Clinical; Communicable Diseases; Communities; Cytolysis; Data; Databases; Deposition; Development; Drug resistance; Engineering; Escherichia coli; Evaluation; Feedback; Future; Goals; Hospitals; Host Defense; Hot Spot; Human; Human Activities; Hydrophobicity; Immune response; Infection; Lead; Legal patent; Length; Letters; Lipids; Lysine; Membrane; Methicillin Resistance; Micelles; Modeling; Modification; Molecular Conformation; Mus; NMR Spectroscopy; Native Americans; Nuclear Magnetic Resonance; Nursing Homes; Outcome; Outcome Study; Pattern; Peptide Hydrolases; Peptides; Phosphatidyl glycerol; Phosphatidylglycerols; Population; Property; Protocols documentation; Publishing; Recombinants; Research; Resistance; Resistance development; Right-On; Role; Schools; Seminal; Side; Staphylococcus aureus; Structure; Structure-Activity Relationship; Students; Surface; System; Testing; Text; Therapeutic; Therapeutic Index; Toxic effect; United States; United States National Institutes of Health; Update; Vertebral column; Work; antimicrobial; antimicrobial drug; antimicrobial peptide; bacterial resistance; base; cathelicidin; chemokine; cytotoxicity; density; design; immunoregulation; improved; in vivo; innovation; insight; interest; killings; meetings; membrane model; methicillin resistant Staphylococcus aureus; mimetics; mouse model; mutant; natural antimicrobial; novel; novel therapeutics; pathogen; pathogenic bacteria; pre-clinical; public health relevance; research study; resistant strain; scaffold; therapeutic target; three dimensional structure; ward; weapons

项目成果

Ab initio design of potent anti-MRSA peptides based on database filtering technology.

• DOI: 10.1021/ja305644e
• 发表时间: 2012-08-01
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Mishra B;Wang G
• 通讯作者: Wang G

Insights into Antimicrobial Peptides from Spiders and Scorpions.

• DOI: 10.2174/0929866523666160511151320
• 发表时间: 2016
• 期刊: Protein and peptide letters
• 影响因子: 1.6
• 作者: Wang X;Wang G
• 通讯作者: Wang G

The Importance of Amino Acid Composition in Natural AMPs: An Evolutional, Structural, and Functional Perspective.

• DOI: 10.3389/fimmu.2012.00221
• 发表时间: 2012
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Mishra B;Wang G
• 通讯作者: Wang G

Structural location determines functional roles of the basic amino acids of KR-12, the smallest antimicrobial peptide from human cathelicidin LL-37.

• DOI: 10.1039/c3ra42599a
• 发表时间: 2013-11-14
• 期刊: RSC advances
• 影响因子: 3.9
• 作者: Mishra B;Epand RF;Epand RM;Wang G
• 通讯作者: Wang G

Human antimicrobial peptides and proteins.

人类抗菌肽和蛋白质。

• DOI: 10.3390/ph7050545
• 发表时间: 2014-05-13
• 期刊: Pharmaceuticals (Basel, Switzerland)
• 作者: Wang G