Role of SM2 and SM1 myosin isoforms in smooth muscle pathophysiology

SM2 和 SM1 肌球蛋白亚型在平滑肌病理生理学中的作用

• 批准号: 8108441
• 负责人: Muthu Periasamy
• 金额: $ 7.63万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2011-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8108441
• 关键词: Ablation; Actins; Address; Adult; Affect; Age; Agonist; Alternative Splicing; Architecture; Asorbicap; Bladder; Bladder Diseases; Bladder Dysfunction; Bladder neck obstruction; C-terminal; Carbachol; Cessation of life; Contractile Proteins; Contracts; Data; Development; Electron Microscopy; Embryo; Exons; Female; Fetal Development; Filament; Functional disorder; Generations; Genes; Goals; Hand; Histology; Isometric Exercise; Kinetics; Knockout Mice; Laboratories; Length; Life; Microfilaments; Molecular; Morphology; Mus; Muscarinic M3 Receptor; Muscle; Muscle Contraction; Muscle Development; Muscle function; Myosin ATPase; Myosin Light Chains; N-terminal; Obstruction; Organ; Phase; Phenotype; Phosphorylation; Physiology; Property; Protein Isoforms; Proteins; Regulation; Research; Research Proposals; Role; Smooth Muscle; Structure; Tamoxifen; Testing; Thick; Thin Filament; Tissues; Tropomyosin; Urethra; Western Blotting; base; caldesmon; calponin; cholinergic; density; detrusor muscle; fetal; genetic regulatory protein; human MYH11 protein; male; man; mature animal; mouse model; muscular structure; myosin phosphatase; postnatal; protein expression; public health relevance; receptor-mediated signaling; response; urinary bladder neck