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SR CA ATPASE, A DETERMINANT OF CARDIAC CONTRACTILITY

SR CA ATPASE, A DETERMINANT OF CARDIAC CONTRACTILITY
SR CA ATP酶，心脏收缩力的决定因素
批准号：
6457377
负责人：
Muthu Periasamy
金额：
$21.68万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-01-15 至 2003-12-31
来源：
https://reporter.nih.gov/project-details/6457377
关键词：
RNase protection assay autoradiography calcineurin calcium binding protein calcium channel calcium transporting ATPase cellular pathology disease /disorder model electrophysiology enzyme activity gene expression gene targeting genetically modified animals heart contraction heart failure homeostasis laboratory mouse membrane transport proteins messenger RNA myocardium phospholamban phosphorylation sarcoplasmic reticulum ventricular hypertrophy western blottings

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英文摘要
DESCRIPTION (adapted from the applicant's description): The central hypothesis of this proposal is that sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) is a critical determinant of myocardial contractility. The proposal has four specific questions (aims). Specific aim 1: Are there homeostatic mechanisms within the cardiac myocyte that are capable of sensing perturbations in the level of SERCA and developing compensatory mechanisms? Specific aim 2: What are the functional consequences of increased or decreased SR calcium uptake on the overall calcium homeostasis within the cardiac myocyte? Specific aim 3: What are the functional consequences of altered SR calcium transport on myocardial performance. Specific aim 4: What is the role of SERCA in cardiac hypertrophy and heart failure? These questions will be studied in transgenic mice with an overexpression of SERCA (both SERCA2a and SERCA1a) and in transgenic mice with a decrease in SERCA (SERCA knockout mice (+/-)).
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Recruitment of skeletal muscle based non-shivering thermogenesis in health and di
  • 批准号：
    8734408
  • 项目类别：
  • 资助金额：
    $33.5万
  • 财政年份：
    2013
  • 负责人：
    Muthu Periasamy
  • 依托单位：
    OHIO STATE UNIVERSITY
Recruitment of skeletal muscle based on non-shivering thermogenesis in health and disease
Recruitment of skeletal muscle based on non-shivering thermogenesis in health and disease
Recruitment of skeletal muscle based on non-shivering thermogenesis in health and disease
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