Dramatic CD4+ T cell depletion without simian AIDS in SIV+ mangabeys

SIV 白眉猴 CD4 T 细胞显着耗竭，但没有出现猿猴艾滋病

• 批准号: 8109669
• 负责人: Donald L Sodora
• 金额: $ 79.58万
• 依托单位: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8109669
• 关键词: Acute; African; Animals; Antibodies; Antigens; B-Lymphocytes; Biological Assay; Blood; CD4 Positive T Lymphocytes; CD8B1 gene; Cell Count; Cells; Cercocebus; Cercocebus atys; Cercopithecus pygerythrus; Chronic; Clinical; Data; Development; Disease Progression; Exhibits; Goals; Gut associated lymphoid tissue; HIV; HIV Infections; HIV vaccine; Health; Helper-Inducer T-Lymphocyte; Human; Immune; Immune response; Immune system; Immunoglobulin Class Switching; Immunologics; Immunotherapy; Infection; Laboratories; Lead; Macaca; Macaca mulatta; Maintenance; Mediating; Messenger RNA; Patients; Phenotype; Plasma; Population; Primates; Publishing; Refractory; Regulatory T-Lymphocyte; Resistance; Role; SIV; Simian Acquired Immunodeficiency Syndrome; T-Cell Depletion; T-Lymphocyte; T-Lymphocyte Subsets; Text; Time; Vaccination; Vaccines; Viral; Virus; Virus Diseases; cell determination; chemokine; cohort; cytokine; design; immune activation; immune function; innovation; interest; lymph nodes; nonhuman primate; novel; novel strategies; peripheral blood; protein expression; public health relevance; receptor; research study; response; simian human immunodeficiency virus

项目成果

Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.

• DOI: 10.1097/coh.0b013e3283504a66
• 发表时间: 2012-03
• 期刊: Current opinion in HIV and AIDS
• 影响因子: 4.1
• 作者: Sundaravaradan V;Mir KD;Sodora DL
• 通讯作者: Sodora DL