Role of Protein-Tyrosine Phosphatase 1B in Pancreatic Islet Function

蛋白酪氨酸磷酸酶 1B 在胰岛功能中的作用

• 批准号: 8038524
• 负责人: Fawaz George Haj
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8038524
• 关键词: Affect; Binding; Biochemical; Cell Communication; Cell physiology; Cells; Complex; Data; Defect; Diabetes Mellitus; Dissection; Event; Failure; Genetically Engineered Mouse; Goals; Homeostasis; Hyperinsulinism; Insulin; Insulin Receptor; Insulin Resistance; Islets of Langerhans; Knock-out; Knockout Mice; Lead; Mediating; Metabolic Diseases; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pancreas; Physiological; Play; Protein Tyrosine Kinase; Protein Tyrosine Phosphatase; Proteins; Regulation; Role; Signal Transduction; Structure of beta Cell of islet; Therapeutic Intervention; Tissues; Tyrosine; Tyrosine Phosphorylation; blood glucose regulation; human IRS2 protein; in vivo; insight; insulin secretion; insulin signaling; islet; mouse model; pancreatic islet function; protein tyrosine phosphatase 1B; therapeutic target; type I and type II diabetes

项目成果

Protein-tyrosine phosphatase 1B substrates and metabolic regulation.

• DOI: 10.1016/j.semcdb.2014.09.020
• 发表时间: 2015-01
• 期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
• 影响因子: 7.3
• 作者: Bakke, Jesse;Haj, Fawaz G.
• 通讯作者: Haj, Fawaz G.

(-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes.

• DOI: 10.1016/j.abb.2012.02.019
• 发表时间: 2012-11-15
• 期刊: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
• 影响因子: 3.9
• 作者: Vazquez-Prieto, Marcela A.;Bettaieb, Ahmed;Haj, Fawaz G.;Fraga, Cesar G.;Oteiza, Patricia I.
• 通讯作者: Oteiza, Patricia I.

(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress.

• DOI: 10.1016/j.freeradbiomed.2014.04.011
• 发表时间: 2014-07
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Bettaieb, Ahmed;Vazquez Prieto, Marcela A.;Rodriguez Lanzi, Cecilia;Miatello, Roberto M.;Haj, Fawaz G.;Fraga, Cesar G.;Oteiza, Patricia I.
• 通讯作者: Oteiza, Patricia I.

Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis.

• DOI: 10.1016/j.metabol.2011.01.004
• 发表时间: 2011-08
• 期刊: METABOLISM-CLINICAL AND EXPERIMENTAL
• 影响因子: 9.8
• 作者: Bettaieb, Ahmed;Matsuo, Kosuke;Matsuo, Izumi;Nagata, Naoto;Chahed, Samah;Liu, Siming;Haj, Fawaz G.
• 通讯作者: Haj, Fawaz G.

Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.

• DOI: 10.1371/journal.pone.0034412
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bettaieb A;Matsuo K;Matsuo I;Wang S;Melhem R;Koromilas AE;Haj FG
• 通讯作者: Haj FG