CNS Plasticity in Pediatric Complex Regional Pain Syndrome
小儿复杂区域疼痛综合征中的中枢神经系统可塑性
基本信息
- 批准号:7984915
- 负责人:
- 金额:$ 33.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAgeAnteriorAreaBiological AssayBiological ProcessBrainBrain regionChildChildhoodClinical DataComplex Regional Pain SyndromesCross-Sectional StudiesDataDevelopmentDiffusion Magnetic Resonance ImagingDissociationEmotionalEvaluationFoundationsFunctional ImagingFunctional Magnetic Resonance ImagingFunctional disorderGenderGoalsHospitalizationHypersensitivityImageImaging TechniquesInsula of ReilInvestigationLateralLegLimb structureLongitudinal StudiesLower ExtremityMagnetic Resonance ImagingMeasuresMechanicsMinorModelingNervous System PhysiologyNeuraxisNeuronal PlasticityPainPain-FreePainlessPatientsPatternPerceptionPhenotypePlayPopulationPrefrontal CortexProcessProtocols documentationQuality of lifeRecoveryRelative (related person)ResearchRestRoleSensoryStimulusStructureSystemTechniquesTestingThickTimeTraumaUnited States National Institutes of Healthbaseblood oxygenation level dependent responsechronic paincingulate cortexcohortdesigneffective therapyfunctional losshealthy volunteerimprovedinsightmultidisciplinaryprogramspublic health relevancerelating to nervous systemresponsesomatosensoryspontaneous paintrendwhite matter
项目摘要
DESCRIPTION (provided by applicant): This proposal is based on our recent imaging studies in children that show our ability to image functional and anatomical changes in a pediatric model of Complex Regional Pain Syndrome (CRPS). CRPS may develop following relatively minor trauma to the limbs. Patients typically present with limb pain and stiffness, hypersensitivity, and functional loss. Unlike adult CRPS, however, pediatric CRPS will usually resolve completely and thus provides a unique model of chronic pain reversal. Our preliminary findings suggest that even minor trauma to a limb may result in significant neural (i.e., structural and functional) changes in the pediatric brain over time, persisting well into and beyond the recovery period. This may well be a distinctive feature of pediatric CRPS and serves as a central focus of this investigation. The overarching goal of the research proposed is to determine whether such changes to the pediatric brain are reversible; and if so, what role this biological process may play in elucidating adult CRPS and in developing more effective therapies for both populations. Against this backdrop, we will investigate neural plasticity using imaging techniques in a longitudinal study of pediatric CRPS patients (in pain and in early pain-free states) and in a cross-sectional study of recovered CRPS patients and healthy controls (up to 24 months following symptomatic recovery). The specific aims are (1) To measure the functional (fMRI) changes in the brains of CRPS patients (ages 14-16) first during the painful state, and then, during the early recovery (within 3 months) state, comparing these changes to those noted in age/gender matched controls; (2) To define plasticity of changes in cortical thickness and white matter tracts (using diffusor tensor imaging - DTI) in pediatric patients ages 14-16 with CRPS affecting their leg during their painful and early recovered states, vs. age/gender matched controls; (3) To measure the same functional (as in Aim 1) and anatomical changes (as in Aim 2) in a cross sectional study of cohorts of recovered CRPS patients at 6, 12 and 24 months following their recovery; we will compare these changes with age- gender matched controls. Each aim will test specific hypotheses related to the functional and anatomical changes that take place in pediatric CRPS population.
PUBLIC HEALTH RELEVANCE: This unique multidisciplinary effort will dovetail with the broader objectives of the NIH Pain Consortium by (1) significantly improving insights into the pathophysiology of both adult and pediatric CRPS; and (2) placing critical emphasis on translational applications leading to more responsive treatments, the elimination of unwanted pain, accelerated recoveries, shorter and less costly hospitalizations, and enhanced quality of life.
描述(由申请人提供):本提案基于我们最近在儿童中进行的成像研究,这些研究显示我们能够对复杂区域疼痛综合征(CRPS)儿科模型中的功能和解剖学变化进行成像。CRPS可能在肢体相对较小的创伤后发展。患者通常表现为肢体疼痛和僵硬、超敏反应和功能丧失。然而,与成人CRPS不同,儿童CRPS通常会完全消退,因此提供了一种独特的慢性疼痛逆转模型。我们的初步研究结果表明,即使是肢体的轻微创伤也可能导致严重的神经损伤(即,结构和功能)的变化,并持续到恢复期之后。这很可能是儿科CRPS的一个显著特征,并作为本研究的中心焦点。这项研究的总体目标是确定儿童大脑的这种变化是否是可逆的;如果是,这种生物学过程在阐明成人CRPS和为这两个人群开发更有效的治疗方法方面可能发挥什么作用。在此背景下,我们将在儿童CRPS患者(疼痛和早期无痛状态)的纵向研究中使用成像技术研究神经可塑性,并在康复的CRPS患者和健康对照(症状恢复后长达24个月)的横断面研究中进行研究。具体目的是:(1)测量CRPS患者脑功能(fMRI)变化(14-16岁)首先是在痛苦的状态下,然后,在早期恢复期间(3个月内)状态,将这些变化与年龄/性别匹配的对照组中观察到的变化进行比较;(2)明确皮质厚度和白色束变化的可塑性(使用弥散张量成像- DTI)在14-16岁的CRPS儿科患者中,与年龄/性别匹配的对照组相比,在他们的疼痛和早期恢复状态期间影响他们的腿;(3)在CRPS患者恢复后6个月、12个月和24个月时,在CRPS恢复患者队列的横断面研究中测量相同的功能(如目标1中所述)和解剖学变化(如目标2中所述);我们将这些变化与年龄-性别匹配的对照进行比较。每个目标将测试与儿童CRPS人群中发生的功能和解剖结构变化相关的特定假设。
公共卫生相关性:这一独特的多学科努力将通过以下方式与NIH疼痛联盟的更广泛目标相吻合:(1)显著提高对成人和儿童CRPS病理生理学的见解;(2)重点关注转化应用,从而实现更有效的治疗,消除不必要的疼痛,加速康复,缩短住院时间,降低住院费用,提高生活质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DAVID BORSOOK其他文献
DAVID BORSOOK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DAVID BORSOOK', 18)}}的其他基金
Perioperative Measures of Nociception using NIRS
使用 NIRS 进行围手术期伤害感受测量
- 批准号:
9752603 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
Perioperative Measures of Nociception using NIRS
使用 NIRS 进行围手术期伤害感受测量
- 批准号:
9388456 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
Central and Peripheral Measures of Pain: Recovery and Resistance
中枢和外周疼痛测量:恢复和抵抗
- 批准号:
8986369 - 财政年份:2015
- 资助金额:
$ 33.52万 - 项目类别:
Post-Traumatic Headache (PTH) in Children: Alterations of Brain Function, Blood Flow and Inflammatory Processes
儿童创伤后头痛 (PTH):脑功能、血流和炎症过程的改变
- 批准号:
9315956 - 财政年份:2015
- 资助金额:
$ 33.52万 - 项目类别:
Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
使用 NIRS 对清醒镇静、麻醉个体进行客观疼痛测量
- 批准号:
8445578 - 财政年份:2013
- 资助金额:
$ 33.52万 - 项目类别:
Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
使用 NIRS 对清醒镇静、麻醉个体进行客观疼痛测量
- 批准号:
8606861 - 财政年份:2013
- 资助金额:
$ 33.52万 - 项目类别:
Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
使用 NIRS 对清醒、镇静、麻醉个体进行客观疼痛测量
- 批准号:
8787757 - 财政年份:2013
- 资助金额:
$ 33.52万 - 项目类别:
Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult
偏头痛随年龄的多模式脑测量:青春期前至成人
- 批准号:
8641734 - 财政年份:2012
- 资助金额:
$ 33.52万 - 项目类别:
Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult
偏头痛随年龄的多模式脑测量:青春期前至成人
- 批准号:
8865698 - 财政年份:2012
- 资助金额:
$ 33.52万 - 项目类别:
Multimodal Brain Measures of Migraine with Age: Prepuberty to Adult
偏头痛随年龄的多模式脑测量:青春期前至成人
- 批准号:
8422983 - 财政年份:2012
- 资助金额:
$ 33.52万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 33.52万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 33.52万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 33.52万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 33.52万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 33.52万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 33.52万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 33.52万 - 项目类别:
Miscellaneous Programs