Musculoskeletal Biomechanics of Gradient Walking in Obese Adults

肥胖成人梯度行走的肌肉骨骼生物力学

• 批准号: 7879855
• 负责人: RAYMOND Clifton BROWNING
• 金额: $ 7.09万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879855
• 关键词: Acute; Adult; Aerobic; Affect; American; Biomechanics; Cardiovascular system; Cessation of life; Child; Data; Databases; Degenerative polyarthritis; Dietary Intervention; Epidemic; Exercise; Expenditure; Gender; Goals; Guidelines; Health; Injury; Intervention; Joints; Knee; Knee Osteoarthritis; Knee joint; Link; Lower Extremity; Measurement; Measures; Metabolic; Morbidity - disease rate; Musculoskeletal; Obesity; Overweight; Oxygen; Oxygen Consumption; Physiological; Positioning Attribute; Regimen; Research; Risk; Source; Speed; Stimulus; Testing; United States; Walking; Weight; Weight maintenance regimen; Weight-Bearing state; combat; cost; design; innovation; joint loading; mortality; musculoskeletal injury; obesity prevention; public health relevance; sound; uptake

DESCRIPTION (provided by applicant): Exercise combined with dietary intervention continues to hold the best promise for combating the obesity epidemic. Brisk walking is a recommended and popular form of exercise but weight bearing exercise may be the source of the biomechanical loads that increase the risk of musculoskeletal injury and link obesity and large joint (e.g. knee) osteoarthritis (OA). Thus, prescribing brisk walking as exercise for treating obesity may be biomechanically unsound. However, remarkably little is known about how obesity affects the biomechanical loads involved in walking. The existing walking biomechanics data base does not apply to the 60+% of American adults who are overweight or obese nor to uphill or downhill walking. The long term goal of this research is to derive walking exercise prescriptions for obese adults that minimize lower extremity biomechanical loads while optimizing caloric expenditure and cardiovascular stimulus. Specific Aim 1: Determine how obesity affects the biomechanics of walking. We hypothesize that obesity increases lower extremity joint loads but that moderate inclines combined with decreased walking speed reduce these loads while walking down moderate declines increases lower extremity joint loads. To test these hypotheses, the musculoskeletal biomechanics will be measured across speed on the level, three inclines and one moderate decline using our inclinable, dual-belt force measuring treadmill. Obese and normal weight control subjects of both genders will be studied. Specific Aim 2: Develop more sound guidelines for prescribing walking exercise for obese adults. We hypothesize that for obese adults, slow walking up a moderate incline minimizes knee joint loads while optimizing caloric expenditure and cardiovascular stimulus. To test this hypothesis, we will combine our biomechanical results from Specific Aim 1 with measurements of the metabolic cost of walking and maximal oxygen consumption rates of obese and normal weight adults. We will be able to identify speed and incline combinations that achieve the recommended sustainable moderate aerobic intensity (55-70% of maximal oxygen uptake, VO2max) with the lowest biomechanical loads. The benefits of this research will be more informed, safer and more effective prescriptions of walking as exercise for weight management and cardiovascular health. The walking regimens that we determine should be safer in the shorter term (reduced rates of acute injuries) and longer term (reduced risk of OA). PUBLIC HEALTH RELEVANCE: Obesity is a chief contributor to preventable deaths in the United States and poses a major health challenge associated with increased morbidity and mortality. Brisk walking is a recommended and popular form of exercise for obesity prevention and treatment but may be the source of the biomechanical loads that increase the risk of musculoskeletal injury and link obesity and large joint (e.g. knee) osteoarthritis. The benefits of this research will be more informed, safer and more effective prescriptions of walking as exercise for weight management and cardiovascular health.

描述（由申请人提供）： 运动与饮食干预相结合仍然是对抗肥胖流行病的最佳方法。快步走是一种推荐和流行的运动形式，但负重运动可能是增加肌肉骨骼损伤风险的生物力学负荷的来源，并将肥胖和大关节（例如膝关节）骨关节炎（OA）联系起来。因此，规定快走作为治疗肥胖的运动可能在生物力学上是不合理的。然而，关于肥胖如何影响行走中的生物力学负荷，人们知之甚少。现有的行走生物力学数据库不适用于60%以上的超重或肥胖的美国成年人，也不适用于上坡或下坡行走。本研究的长期目标是为肥胖成年人制定步行运动处方，最大限度地减少下肢生物力学负荷，同时优化热量消耗和心血管刺激。具体目标1：确定肥胖如何影响行走的生物力学。我们假设，肥胖增加下肢关节负荷，但中度倾斜结合步行速度降低降低这些负荷，而步行中度下降增加下肢关节负荷。为了验证这些假设，将使用我们的可倾斜双带测力跑步机在水平速度、三个倾斜速度和一个适度下降速度上测量肌肉骨骼生物力学。将研究两种性别的肥胖和正常体重对照受试者。具体目标2：为肥胖成年人制定更合理的步行运动处方指南。我们假设，对于肥胖的成年人，缓慢走上一个中等的斜坡，最大限度地减少膝关节的负荷，同时优化热量消耗和心血管刺激。为了验证这一假设，我们将结合联合收割机的生物力学结果，从具体目标1与测量的代谢成本的步行和最大耗氧率的肥胖和正常体重的成年人。我们将能够确定速度和倾斜组合，以达到推荐的可持续中等有氧强度（最大摄氧量的55-70%，VO 2 max）和最低的生物力学负荷。这项研究的好处将是更明智，更安全，更有效的步行处方作为体重管理和心血管健康的运动。我们确定的步行方案在短期内（降低急性损伤率）和长期内（降低OA风险）应该更安全。 公共卫生关系：肥胖是美国可预防死亡的主要原因，并构成与发病率和死亡率增加相关的重大健康挑战。快步走是一种推荐和流行的预防和治疗肥胖的运动形式，但可能是生物力学负荷的来源，增加了肌肉骨骼损伤的风险，并将肥胖和大关节（如膝关节）骨关节炎联系起来。这项研究的好处将是更明智，更安全，更有效的步行处方作为体重管理和心血管健康的运动。