The Effect of Vaporized Cannabis on Neuropathic Pain in Spinal Cord Injury

汽化大麻对脊髓损伤神经病理性疼痛的影响

• 批准号: 8186386
• 负责人: Barth Lance Wilsey
• 金额: $ 25.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8186386
• 关键词: Adverse effects; Affect; Affective; Analgesics; Antiemetics; Area; Attention; Auditory; Behavioral; Biological Availability; Breathing; Cannabidiol; Cannabinoids; Cannabis; Clinical; Cognition; Cross-Over Studies; Development; Digit structure; Dissociation; Distress; Dose; Double-Blind Method; Effectiveness; Emotional; Euphoria; Exposure to; Funding Opportunities; Goals; Grant; Heating; Impaired cognition; Impairment; Individual; Intoxication; Learning; Link; Marijuana; Measurement; Measures; Medicine; Memory; Mental Health; Mental disorders; Modality; Modeling; Moods; Multiple Sclerosis; National Institute of Drug Abuse; Nociception; Pain; Pain Research; Panic; Patients; Placebos; Preparation; Psychomotor Performance; Randomized; Reaction Time; Relative (related person); Relaxation; Reporting; Sativex; Schizophrenia; Sedation procedure; Sensory; Sleep disturbances; Smoking; Spinal cord injury; Tachycardia; Techniques; Testing; Tetrahydrocannabinol; Trail Making Test; Vaporizer; Variant; Verbal Learning; allodynia; base; cognitive change; design; heat stimulus; human subject; mechanical allodynia; neuropsychological; painful neuropathy; processing speed; response; spinal cord injury pain; suicidal risk

DESCRIPTION (provided by applicant): The present study will be designed to evaluate the analgesic effects of vaporized cannabis in patients with neuropathic pain due to spinal cord injury. A within-subject crossover study of the effects of cannabis (3.5% and 7.0% delta-9-THC) versus placebo on spontaneous and evoked pain will be performed. Both pain intensity and pain unpleasantness will be assessed to see if marijuana affects sensory-discriminative pain more or less than the motivational-affective component. If present, areas of mechanical allodynia will be assessed with repeated testing to determine the degree of the allodynia regression (if any) after inhaling cannabis via a vaporizer. Heat evoked pain will be studied using mild to moderately painful heat stimuli delivered to the painful area of the subject's body using an electronically controlled Peltier contact thermode via a Medoc TSA 2001 quantitative sensory tester. Neuropsychological functioning (attention, learning and memory, and psychomotor performance) will be evaluated with the Digit Symbol Modalities Test, the Hopkins Verbal Learning Test, the Grooved Pegboard Test Trail Making Test and the Paced Auditory Serial Addition Test (PASAT) before and after the administration of vaporized cannabis. Emotional responses will be evaluated using the Profile of Moods States. The degree of antinociception will then be compared with neuropsychological and mood effects of cannabis for a synopsis of the relative effectiveness (i.e., efficacy versus side-effects) of the doses employed. The major hypothesis will be that vaporized cannabis can induce antinociceptive changes in spontaneous and evoked pain in subjects with neuropathic pain. The second hypothesis will be that the higher dose of cannabis (7.0%) employed will induce the same or a greater degree of antinociception that is not independent of differences in mood, cognition, and psychomotor performance. PUBLIC HEALTH RELEVANCE: This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury. To further evaluate potential benefits and side effects, the effect of different strengths of cannabis on mood, cognition and psychomotor performance will also be measured.

描述（由申请人提供）：本研究旨在评价汽化大麻对脊髓损伤所致神经性疼痛患者的镇痛作用。将进行大麻（3.5%和7.0% δ-9-THC）与安慰剂对自发性和诱发性疼痛影响的受试者内交叉研究。疼痛强度和疼痛不愉快都将被评估，看看大麻对感觉辨别性疼痛的影响是否大于或小于动机情感成分。如果存在，将通过重复测试评估机械性异常性疼痛的区域，以确定通过汽化器吸入大麻后异常性疼痛消退的程度（如果有）。使用Medoc TSA 2001定量感觉测试仪，使用电子控制Peltier接触式热电极，将轻度至中度疼痛热刺激传递至受试者身体的疼痛区域，研究热诱发疼痛。在给予汽化大麻之前和之后，将使用数字符号模态测试、霍普金斯言语学习测试、凹槽钉板测试、连线测试和起搏听觉序列加法测试（PASAT）评价神经心理功能（注意力、学习和记忆以及精神表现）。情绪反应将使用情绪状态特征进行评估。然后将抗伤害感受的程度与大麻的神经心理学和情绪效应进行比较，以概括相对有效性（即，功效与副作用）。 主要的假设是，汽化大麻可以诱导神经性疼痛受试者的自发性和诱发性疼痛的抗伤害性变化。第二个假设是，使用更高剂量的大麻（7.0%）将诱导相同或更大程度的抗伤害感受，这与情绪，认知和心理表现的差异无关。 公共卫生相关性：这项研究将证明，在脊髓损伤受试者中，与安慰剂相比，蒸发的大麻具有抗伤害作用。为了进一步评估潜在的益处和副作用，还将测量不同强度的大麻对情绪，认知和心理表现的影响。